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Open Access 01-04-2014 | Letter

In silicoanalysis of microRNA-510 as a potential oncomir in human breast cancer

Authors: Pawel Gaj, Radoslaw Zagozdzon

Published in: Breast Cancer Research | Issue 2/2014

Excerpt

In a recent issue of Breast Cancer Research, Guo and colleagues provided mechanistic evidence supporting the role for microRNA (miR)-510 as a novel oncomir playing a pivotal role in human breast cancer via regulation of expression of peroxiredoxin 1 [1]. Their study follows the original observation of elevated miR-510 expression in human breast tumor samples described by Findlay and colleagues in 2008 [2]. …

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Guo QJ, Mills JN, Bandurraga SG, Nogueira LM, Mason NJ, Camp ER, Larue AC, Turner DP, Findlay VJ: MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer. Breast Cancer Res. 2013, 15: R70-10.1186/bcr3464.CrossRefPubMedPubMedCentral

Findlay VJ, Turner DP, Moussa O, Watson DK: MicroRNA-mediated inhibition of prostate-derived Ets factor messenger RNA translation affects prostate-derived Ets factor regulatory networks in human breast cancer. Cancer Res. 2008, 68: 8499-8506. 10.1158/0008-5472.CAN-08-0907.CrossRefPubMedPubMedCentral

The Cancer Genome Atlas Network: Comprehensive molecular portraits of human breast tumours. Nature. 2012, 490: 61-70. 10.1038/nature11412.CrossRefPubMedCentral

Farazi TA, Horlings HM, Ten HJ, Mihailovic A, Halfwerk H, Morozov P, Brown M, Hafner M, Reyal F, van Kouwenhove M, Kreike B, Sie D, Hovestadt V, Wessels L, van de Vijver MJ, Tuschl T: MicroRNA sequence and expression analysis in breast tumors by deep sequencing. Cancer Res. 2011, 71: 4443-4453. 10.1158/0008-5472.CAN-11-0608.CrossRefPubMedPubMedCentral

Enerly E, Steinfeld I, Kleivi K, Leivonen S-K, Aure MR, Russnes HG, Rønneberg JA, Johnsen H, Navon R, Rødland E, Mäkelä R, Naume B, Perälä M, Kallioniemi O, Kristensen VN, Yakhini Z, Børresen-Dale A-L: miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors. PLoS One. 2011, 6: e16915-10.1371/journal.pone.0016915.CrossRefPubMedPubMedCentral

Title: In silicoanalysis of microRNA-510 as a potential oncomir in human breast cancer
Authors: Pawel Gaj
Radoslaw Zagozdzon
Publication date: 01-04-2014
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 2/2014
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr3624

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