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Breast Cancer Research
Published in: Breast Cancer Research 5/2001

01-10-2001 | Review

Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations

Authors: Kaye J Williams, Rachel L Cowen, Ian J Stratford

Published in: Breast Cancer Research | Issue 5/2001

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Abstract

Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies.
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Metadata
Title
Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations
Authors
Kaye J Williams
Rachel L Cowen
Ian J Stratford
Publication date
01-10-2001
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2001
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr316

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