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01-02-2000 | Review

Imaging biochemistry: applications to breast cancer

Authors: Sabrina M Ronen, Martin O Leach

Published in: Breast Cancer Research | Issue 1/2000

Abstract

The use of magnetic resonance spectroscopy (MRS) to investigate breast tumour biochemistry in vivo is reviewed. To this end, results obtained both from patients in vivo and from tumour extracts and model systems are discussed. An association has been observed between transformation and an increase in phosphomonoesters (PMEs) detected in the ³¹P MRS spectrum, as well as an increase in choline-containing metabolites detected in the ¹H spectrum. A decrease in PME content after treatment is associated with response to treatment as assessed by tumour volume. Experiments in model systems aimed at understanding the underlying biochemical processes are presented, as well as data indicating the usefulness of MRS in monitoring the uptake and metabolism of some chemotherapeutic agents.

Degani H, Horowitz A, Itzchak Y: Breast tumors: Evaluation with P-31 MR spectroscopy. Radiology. 1986, 161: 53-55.CrossRefPubMed

Merchant TE, Gierke LW, Meneses P, Glonek T: ³¹P magnetic resonance spectroscopic profiles of neoplastic human breast tissues. Cancer Res. 1988, 48: 5112-5118.PubMed

Smith TAD, Bush C, Jameson C, Titley JC, Leach MO, Wilman DEV, McCready VR: Phospholipid metabolites, prognosis and proliferation in human breast carcinoma. NMR Biomed. 1993, 6: 318-323.CrossRefPubMed

Degani H, Ronen SM, Furman-Haran E: Breast cancer: spectroscopy and imaging of cells and tumors. In NMR in Physiology and Biomedicine. Edited by Gillies RJ. San Diego: Academic Press;. 1994, 329-352.CrossRef

Howells SL, Maxwell RJ, Howe FA, Peet AC, Stubbs M, Rodrigues LM, Robinson SP, Baluch S, Griffiths JR: Pattern recognition of ³¹P magnetic resonance spectroscopy tumour spectra obtained in vivo. NMR Biomed. 1993, 6: 237-241.CrossRefPubMed

Aboagye EO, Bhujwalla ZM: Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res. 1999, 59: 80-84.PubMed

Bhujwalla ZM, Aboagye EO, Gillies RJ, Chacko VP, Mendola CE, Backer JM: Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a ³¹P nuclear magnetic resonance study in vivo and vitro. Magn Reson Med. 1999, 41: 897-903. 10.1002/(SICI)1522-2594(199905)41:5<897::AID-MRM7>3.3.CO;2-K.CrossRefPubMed

Gribbestad IS, Petersen SB, Fjosne HE, Kvinnsland S, Krane J: ¹H NMR spectroscopic characterization of perchloric acid extracts from breast carcinomas and non-involved breast tissue. NMR Biomed. 1994, 7: 181-194.CrossRefPubMed

Mackinnon WB, Barry PA, Malycha PL, Gillett DJ, Russell P, Lean CL, Barraclough BH, Bilous M, Mountford CE: Fine-needle biopsy specimens of benign breast lesions distinguished from invasive cancer ex vivo with proton MR spectroscopy. Radiology. 1997, 204: 661-666.CrossRefPubMed

10.

Podo F: Tumour phospholipid metabolism. NMR Biomed. 1999, 12: 413-439. 10.1002/(SICI)1099-1492(199911)12:7<413::AID-NBM587>3.3.CO;2-L.CrossRefPubMed

11.

Katz-Brull R, Degani H: Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method. Anticancer Res. 1996, 16: 1375-1379.PubMed

12.

Ronen SM, Volk A, Mispelter J: Comparative NMR study of a differentiated rat hepatoma and its dedifferentiated subclone cultured as spheroids and as implanted tumors. NMR Biomed. 1994, 7: 278-282.CrossRefPubMed

13.

Ronen SM, DiStefano F, McCoy CL, Robertson D, Smith TAD, Al-Saffar NM, Titley J, Cunningham DC, Griffiths JR, Leach MO, Clarke PA: Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis. Br J Cancer. 1999, 80: 1035-1041. 10.1038/sj.bjc.6690459.CrossRefPubMedPubMedCentral

14.

Griffiths JR: Are cancer cells acidic?. Br J Cancer. 1991, 64: 425-427.CrossRefPubMedPubMedCentral

15.

Gillies RJ, Bhujwalla ZM, Evelhoch J, Garwood M, Neeman M, Robinson SP, Sotak CH, Van der Sanden B: Applications of magnetic resonance in model systems: Tumor biology and physiology. Neoplasia. 2000, 2: 139-151. 10.1038/sj.neo.7900076.CrossRefPubMedPubMedCentral

16.

Evelhoch JL, Gillies RJ, Karczmar GS, Koutcher JA, Nalcioglu O, Raghunand N, Ronen SM, Ross BD, Swartz HM: Applications of magnetic resonance in model systems: cancer therapeutics. Neoplasia. 2000, 2: 152-165. 10.1038/sj.neo.7900078.CrossRefPubMedPubMedCentral

17.

Steen RG: Response of solid tumors to chemotherapy monitored by in vivo ³¹P magnetic resonance spectroscopy: a review. Cancer Res. 1989, 49: 4075-4085.PubMed

18.

Daly PF, Cohen JS: Magnetic resonance spectroscopy of tumors and potential in vivo clinical applications: a review. Cancer Res. 1989, 49: 770-779.PubMed

19.

Griffiths JR, Glickson JD: Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance spectroscopy. Adv Drug Deliv Rev. 2000, 41: 75-89. 10.1016/S0169-409X(99)00057-5.CrossRefPubMed

20.

Stegman LD, Rehemtulla A, Beattie B, Kievit E, Lawrence TS, Blasberg RG, Tjuvajev JG, Ross BD: Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci USA. 1999, 96: 9821-9826. 10.1073/pnas.96.17.9821.CrossRefPubMedPubMedCentral

21.

Walter G, Barton ER, Sweeney HL: Noninvasive measurement of gene expression in skeletal muscle. Proc Natl Acad Sci USA. 2000, 97: 5151-5155. 10.1073/pnas.97.10.5151.CrossRefPubMedPubMedCentral

22.

Negendank W: Studies of human tumors by MRS: a review. NMR Biomed. 1992, 5: 303-324.CrossRefPubMed

23.

Leach MO, Verrill M, Glaholm J, Smith TAD, Collins DJ, Sharp JC, Ronen SM, McCready VR, Powles TJ, Smith IE: Measurements of human breast cancer using magnetic resonance spectroscopy: a review of clinical measurements and a report of localized ³¹P measurements of response to treatment. NMR Biomed. 1998, 11: 314-340. 10.1002/(SICI)1099-1492(1998110)11:7<314::AID-NBM522>3.0.CO;2-Z.CrossRefPubMed

24.

Roebuck JR, Cecil KM, Schnall MD, Lenkinski RE: Human breast lesions: characterization with proton MR spectroscopy. Radiology. 1998, 209: 269-275.CrossRefPubMed

25.

Kvistad KA, Bakken IJ, Gribbestad IS, Ehrnholm B, Fjosne HE, Haraldseth O: Characterization of neoplastic and normal human breast tissues with in vivo ¹ H MR spectroscopy. J Magn Reson Imaging. 1999, 10: 159-164. 10.1002/(SICI)1522-2586(199908)10:2<159::AID-JMRI8>3.0.CO;2-0.CrossRefPubMed

26.

Arias-Mendoza F, Brown TR, Charles HC, Zakian K, Schwarz A, Doyle V, Nelson SJ, Rijkema M, Glickson JD, Evlehoch JL: Methodological standardization for a multi-institutional in vivo trial of localized ³¹P MR spectroscopy in human cancer research [abstract]. Proc Int Soc Magn Reson Med. 1999, 3: 1585-

27.

Wolf W, Waluch V, Presant CA: Non-invasive ¹⁹F-NMRS of 5-fluorouracil in pharmacokinetics and pharmacodynamic studies. NMR Biomed. 1998, 11: 380-387. 10.1002/(SICI)1099-1492(1998110)11:7<380::AID-NBM517>3.0.CO;2-Q.CrossRefPubMed

28.

Smith TAD, Glaholm J, Leach MO, Machin L, Collins DJ, Payne GS, McCready VR: A comparison of in vivo and in vitro ³¹P NMR spectra from human breast tumours: variations in phosphlipid metabolism. Br J Cancer. 1991, 63: 514-516.CrossRefPubMedPubMedCentral

Title: Imaging biochemistry: applications to breast cancer
Authors: Sabrina M Ronen
Martin O Leach
Publication date: 01-02-2000
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 1/2000
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr268

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