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01-04-2010 | Viewpoint

On the theory of tumor self-seeding: implications for metastasis progression in humans

Author: Julio A Aguirre-Ghiso

Published in: Breast Cancer Research | Issue 2/2010

Abstract

Metastasis remains the leading cause of death among cancer patients because few effective treatment options are available. A recent paper proposes a new twist on metastasis. The paper shows that circulating tumor cells can return to the primary tumor, a process termed tumor self-seeding or cross-seeding, and that this helps breeding tumor cells that give rise to aggressive metastatic variants. A viewpoint presented here addresses the implications of these studies for human cancer metastasis.

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Title: On the theory of tumor self-seeding: implications for metastasis progression in humans
Author: Julio A Aguirre-Ghiso
Publication date: 01-04-2010
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 2/2010
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2561

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