Published in:
01-05-2010 | Poster presentation
Anti-HER2 imaging agents for breast cancer imaging
Authors:
B Tolner, K Vigor, S Mather, M Robinson, G Adams, A Plueckthun, K Chester
Published in:
Breast Cancer Research
|
Special Issue 1/2010
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Excerpt
Overexpression of human epidermal growth factor receptor 2 (HER2) tyrosine kinase cell surface receptor occurs in 25 to 30% of all breast cancer and is linked to aggressive phenotype and high-mortality disease. HER2 is a clinically important target in diagnosis and treatment of breast cancer but despite its pivotal role there are no established tools for quantitative clinical imaging of the extent and location of HER2-positive (HER2+) tumours in patients. Such a tool could provide important clinical diagnostic information by early detection of subclinical HER2+ disease, optimal management of current anti-HER2 therapies and response assessment of novel therapeutics. We aimed to generate recombinant proteins that would achieve sensitive and specific detection of HER2+ tumours in the clinic using radioimmunoimaging. …
