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01-10-2007 | Review

P-cadherin expression in breast cancer: a review

Authors: Joana Paredes, Ana Luísa Correia, Ana Sofia Ribeiro, André Albergaria, Fernanda Milanezi, Fernando C Schmitt

Published in: Breast Cancer Research | Issue 5/2007

Abstract

P-cadherin is frequently over-expressed in high-grade invasive breast carcinomas and has been reported to be an enhancer of migration and invasion of breast cancer cells, being correlated with tumour aggressiveness. In addition, expression of P-cadherin is well established as an indicator of poor prognosis in human breast cancer, which has stimulated our interest in studying its role in this setting. This review describes the most important findings on P-cadherin expression and function in normal mammary tissue and breast cancer cells, emphasizing that further research is required to elucidate the role played by this protein in human mammary tumours.

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Title: P-cadherin expression in breast cancer: a review
Authors: Joana Paredes
Ana Luísa Correia
Ana Sofia Ribeiro
André Albergaria
Fernanda Milanezi
Fernando C Schmitt
Publication date: 01-10-2007
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 5/2007
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1774

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