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Breast Cancer Research
Published in: Breast Cancer Research 3/2007

Open Access 01-06-2007 | Research article

Association of TP53codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients

Authors: Tatsuya Toyama, Zhenhuan Zhang, Mariko Nishio, Maho Hamaguchi, Naoto Kondo, Hirotaka Iwase, Hiroji Iwata, Satoru Takahashi, Hiroko Yamashita, Yoshitaka Fujii

Published in: Breast Cancer Research | Issue 3/2007

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Abstract

Introduction

Single-nucleotide polymorphisms (SNPs) in codon 72 of the TP53 (also known as p53) gene (rs1042522) and in the promoter region of the MDM2 gene (SNP309; rs2279744) have been suggested to play roles in many cancers. We investigated whether these SNPs were associated with patient outcome and the effect of adjuvant systemic therapy.

Methods

The genotypes of TP53 codon 72 and MDM2 SNP309 were defined among 557 primary Japanese breast cancer patients (median follow-up, 61.7 months). The effects of several variables on survival were tested by Cox's proportional hazards regression analysis.

Results

We showed that the Pro/Pro genotype of TP53 codon 72 was associated with poorer disease-free survival (DFS) than other genotypes by Kaplan-Meier analysis (P = 0.049) and multivariate Cox's proportional hazards regression analysis (P = 0.047, risk ratio of recurrence = 1.67), whereas MDM2 SNP309 status was not associated with DFS. The association of the Pro/Pro TP53 genotype with poorer DFS was especially significant in patients who received adjuvant chemotherapy (P = 0.009). In contrast, among the patients who had received adjuvant hormonal therapy or no adjuvant systemic therapy, TP53 codon 72 genotype was not associated with DFS.

Conclusion

The Pro/Pro genotype of TP53 codon 72 appears to be an independent prognostic marker in breast cancer patients.
Appendix
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Metadata
Title
Association of TP53codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients
Authors
Tatsuya Toyama
Zhenhuan Zhang
Mariko Nishio
Maho Hamaguchi
Naoto Kondo
Hirotaka Iwase
Hiroji Iwata
Satoru Takahashi
Hiroko Yamashita
Yoshitaka Fujii
Publication date
01-06-2007
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2007
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1682

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