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01-12-2007 | Review

HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors

Authors: Neil Spector, Wenle Xia, Iman El-Hariry, Yossi Yarden, Sarah Bacus

Published in: Breast Cancer Research | Issue 2/2007

Abstract

Overexpression of the human epidermal growth factor receptor (HER)-2 oncogenic receptor tyrosine kinase, which occurs in 25% of breast cancers, portends poor clinical outcome and consequently represents an attractive target for therapeutic intervention. Small molecule tyrosine kinase inhibitors that compete with ATP binding at the cytoplasmic catalytic kinase domain of HER-2 block autophosphorylation and activation of HER-2, resulting in inhibition of downstream proliferation and survival signals. These agents have exhibited clinical activity in patients with HER-2 overexpressing breast cancers. Here we review the development of HER-2 tyrosine kinase inhibitors, their mechanisms of action, their biological and clinical activities, their safety profile, and combination strategies including conventional cytotoxics and other targeted agents.

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Title: HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors
Authors: Neil Spector
Wenle Xia
Iman El-Hariry
Yossi Yarden
Sarah Bacus
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 2/2007
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1652

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