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Breast Cancer Research
Published in: Breast Cancer Research 6/2006

01-12-2006 | Review

Measuring proliferation in breast cancer: practicalities and applications

Authors: Mark J Beresford, George D Wilson, Andreas Makris

Published in: Breast Cancer Research | Issue 6/2006

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Abstract

Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with other novel approaches is reviewed in relation to breast cancer. The potential clinical applications of proliferative indices are discussed, including their use as prognostic indicators and predictors of response to systemic therapy.
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Metadata
Title
Measuring proliferation in breast cancer: practicalities and applications
Authors
Mark J Beresford
George D Wilson
Andreas Makris
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1618

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