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Breast Cancer Research
Published in: Breast Cancer Research 4/2006

01-08-2006 | Commentary

Stop! In the name of transforming growth factor-β: keeping estrogen receptor-α-positive mammary epithelial cells from proliferating

Authors: Sandra L Grimm, Jeffrey M Rosen

Published in: Breast Cancer Research | Issue 4/2006

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Abstract

Recent genetic and cell biological studies illustrate the importance of active transforming growth factor-β signaling in preventing the proliferation of estrogen receptor-positive cells in the normal mammary gland, and suggest how the loss of this inhibition may be important in early breast cancer progression.
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Literature
1.
Ewan KB, Oketch-Rabah HA, Ravani SA, Shyamala G, Moses HL, Barcellos-Hoff MH: Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor β1 in adult mice. Am J Pathol. 2005, 167: 409-417.CrossRefPubMedPubMedCentral
2.
Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L, Barcellos-Hoff MH: Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. Am J Pathol. 2002, 160: 2081-2093.CrossRefPubMedPubMedCentral
3.
Clarke RB, Howell A, Potten CS, Anderson E: Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res. 1997, 57: 4987-4991.PubMed
4.
Russo J, Ao X, Grill C, Russo IH: Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland. Breast Cancer Res Treat. 1999, 53: 217-227. 10.1023/A:1006186719322.CrossRefPubMed
5.
Seagroves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM: C/EBPβ (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol Endocrinol. 2000, 14: 359-368. 10.1210/me.14.3.359.PubMed
6.
Capuco AV, Ellis S, Wood DL, Akers RM, Garrett W: Postnatal mammary ductal growth: three-dimensional imaging of cell proliferation, effects of estrogen treatment, and expression of steroid receptors in prepubertal calves. Tissue Cell. 2002, 34: 143-154. 10.1016/S0040-8166(02)00024-1.CrossRefPubMed
7.
Brisken C, Park S, Vass T, Lydon JP, O'Malley BW, Weinberg RA: A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci USA. 1998, 95: 5076-5081. 10.1073/pnas.95.9.5076.CrossRefPubMedPubMedCentral
8.
Mallepell S, Krust A, Chambon P, Brisken C: Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci USA. 2006, 103: 2196-2201. 10.1073/pnas.0510974103.CrossRefPubMedPubMedCentral
9.
Medina D, Kittrell FS, Shepard A, Stephens LC, Jiang C, Lu J, Allred DC, McCarthy M, Ullrich RL: Biological and genetic properties of the p53 null preneoplastic mammary epithelium. FASEB J. 2002, 16: 881-883.PubMed
10.
Shoker BS, Jarvis C, Clarke RB, Anderson E, Hewlett J, Davies MP, Sibson DR, Sloane JP: Estrogen receptor-positive proliferating cells in the normal and precancerous breast. Am J Pathol. 1999, 155: 1811-1815.CrossRefPubMedPubMedCentral
11.
Barcellos-Hoff MH: Latency and activation in the control of TGF-β. J Mammary Gland Biol Neoplasia. 1996, 1: 353-363. 10.1007/BF02017391.CrossRef
12.
Tang B, Bottinger EP, Jakowlew SB, Bagnall KM, Mariano J, Anver MR, Letterio JJ, Wakefield LM: Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency. Nat Med. 1998, 4: 802-807. 10.1038/nm0798-802.CrossRefPubMed
13.
Medina D, Sivaraman L, Hilsenbeck SG, Conneely O, Ginger M, Rosen J, Omalle BW: Mechanisms of hormonal prevention of breast cancer. Ann NY Acad Sci. 2001, 952: 23-35.CrossRefPubMed
14.
Boulanger CA, Wagner KU, Smith GH: Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression. Oncogene. 2005, 24: 552-560. 10.1038/sj.onc.1208185.CrossRefPubMed
15.
Boulanger CA, Smith GH: Reducing mammary cancer risk through premature stem cell senescence. Oncogene. 2001, 20: 2264-2272. 10.1038/sj.onc.1204312.CrossRefPubMed
16.
Grimm SL, Contreras A, Barcellos-Hoff MH, Rosen JM: Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPβ)-null mice. J Biol Chem. 2005, 280: 36301-36309. 10.1074/jbc.M508167200.CrossRefPubMed
17.
Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, Koff A: p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 1994, 8: 9-22.CrossRefPubMed
18.
Foster JS, Henley DC, Bukovsky A, Seth P, Wimalasena J: Multi-faceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function. Mol Cell Biol. 2001, 21: 794-810. 10.1128/MCB.21.3.794-810.2001.CrossRefPubMedPubMedCentral
19.
Lee WR, Chen CC, Liu S, Safe S: 17β-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways. J Cell Biochem.
20.
Ray D, Terao Y, Nimbalkar D, Chu LH, Donzelli M, Tsutsui T, Zou X, Ghosh AK, Varga J, Draetta GF, et al: Transforming growth factor β facilitates β-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol. 2005, 25: 3338-3347. 10.1128/MCB.25.8.3338-3347.2005.CrossRefPubMedPubMedCentral
21.
Alkarain A, Jordan R, Slingerland J: p27 deregulation in breast cancer: prognostic significance and implications for therapy. J Mammary Gland Biol Neoplasia. 2004, 9: 67-80. 10.1023/B:JOMG.0000023589.00994.5e.CrossRefPubMed
Metadata
Title
Stop! In the name of transforming growth factor-β: keeping estrogen receptor-α-positive mammary epithelial cells from proliferating
Authors
Sandra L Grimm
Jeffrey M Rosen
Publication date
01-08-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 4/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1520

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