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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2012

01-11-2012 | Review

B-cell activating factor targeted therapy and lupus

Authors: Alexis Boneparth, Anne Davidson

Published in: Arthritis Research & Therapy | Special Issue 4/2012

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Abstract

B-cell activating factor (BAFF), a member of the family of TNF-like cytokines, supports the survival and differentiation of B cells. The successful development of belimumab, a human antibody targeting soluble BAFF, has marked an important milestone in the development of biologic therapy for treatment of systemic lupus erythematosus (SLE), although much remains unknown regarding the clinical utility of BAFF inhibition in SLE and other autoimmune diseases. In the present review, we provide an overview of the knowledge concerning BAFF's role in murine and human B-cell development and maturation, as well as the clinical and mechanistic effects of BAFF inhibition in human SLE.
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Metadata
Title
B-cell activating factor targeted therapy and lupus
Authors
Alexis Boneparth
Anne Davidson
Publication date
01-11-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 4/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3920
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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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