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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 6/2001

Open Access 01-09-2001 | Research article

Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration

Authors: Olof H Hultgren, Andrej Tarkowski

Published in: Arthritis Research & Therapy | Issue 6/2001

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Abstract

Weight loss is typically found during severe infections, e.g. septic arthritis. The aim of our study was to evaluate the role of leptin, regulator of food intake and energy expenditure, for the development of Staphylococcus aureus-triggered arthritis. Leptin production was found to be decreased during murine S. aureus-induced arthritis. Treatment with recombinant leptin neither restored the basal leptin levels nor affected the weight loss during the disease, but it significantly decreased the severity of septic arthritis. Exogenous leptin did not affect the staphylococcal load as measured in blood, joints and kidneys. Preceding the effects on joint manifestations, serum levels of interleukin-6 decreased in leptin-treated mice. In conclusion, the treatment with recombinant leptin reduced both the severity of joint manifestations in S.aureus-induced arthritis and the inflammatory response, as measured by serum IL-6 levels, without affecting the survival of bacteria in vivo.
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Metadata
Title
Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration
Authors
Olof H Hultgren
Andrej Tarkowski
Publication date
01-09-2001
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 6/2001
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar332

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