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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2009

01-04-2009 | Review

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

Authors: Sarah R Walmsley, Edwin R Chilvers, Moira KB Whyte

Published in: Arthritis Research & Therapy | Issue 2/2009

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Abstract

With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.
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Metadata
Title
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
Authors
Sarah R Walmsley
Edwin R Chilvers
Moira KB Whyte
Publication date
01-04-2009
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2009
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2632

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