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01-02-2008 | Review

The role of tumor necrosis factor-alpha in systemic lupus erythematosus

Authors: Martin Aringer, Josef S Smolen

Published in: Arthritis Research & Therapy | Issue 1/2008

Abstract

Murine models of systemic lupus erythematosus (SLE) have shown apparently contradictory evidence in that either (a) tumor necrosis factor (TNF) expression was low and TNF administration helpful or (b) TNF was high and TNF blockade of therapeutic benefit, depending on the mouse model investigated. In fact, TNF apparently has both effects, checking autoimmunity, at least to some degree, and fostering inflammation. TNF blockade regularly, but transiently, induces or increases autoantibodies to chromatin and to phospholipids. At the same time, open-label data suggest that TNF blockade suppresses inflammatory manifestations of SLE, and long-term benefit was seen in patients with lupus nephritis. A controlled clinical trial is under way.

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ClinicalTrials.gov home page. [http://www.clinicaltrials.gov]

Title: The role of tumor necrosis factor-alpha in systemic lupus erythematosus
Authors: Martin Aringer
Josef S Smolen
Publication date: 01-02-2008
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 1/2008
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2341

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