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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2001

Open Access 01-01-2001 | Research article

Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8

Authors: Kenji Hayashida, Toshihiro Nanki, Hermann Girschick, Sule Yavuz, Takahiro Ochi, Peter E Lipsky

Published in: Arthritis Research & Therapy | Issue 2/2001

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Abstract

Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally.
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Metadata
Title
Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8
Authors
Kenji Hayashida
Toshihiro Nanki
Hermann Girschick
Sule Yavuz
Takahiro Ochi
Peter E Lipsky
Publication date
01-01-2001
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2001
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar149

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