Skip to main content
Top
Published in: Arthritis Research & Therapy 6/2000

01-09-2000 | Review

Bone loss: Quantitative imaging techniques for assessing bone mass in rheumatoid arthritis

Authors: Christopher F Njeh, Harry K Genant

Published in: Arthritis Research & Therapy | Issue 6/2000

Login to get access

Abstract

Osteoporosis is associated with low bone mass and microarchitectural deterioration of bone tissue with clinical manifestation of low trauma fractures. Rheumatoid arthritis (RA) is a risk factor due to generalized and articular bone loss. This minireview presents past and current bone mass measurement techniques in RA. These techniques include: plain radiographs, absorptiometry, quantitative computed tomography (QCT) and ultrasound. The most widely used technique is dual x-ray absorptiometry (DXA). RA patients have lower bone mass as compared with normals and substantial bone loss may occur early after the onset of disease. Measurement of bone mineral density (BMD) at the hand using either DXA or ultrasound maybe a useful tool in the management of RA patients.
Literature
1.
go back to reference Gough AK, Lilley J, Eyre S, Holder RL, Emery P: Generalised bone loss in patients with early rheumatoid arthritis. Lancet. 1994, 344: 23-27.PubMed Gough AK, Lilley J, Eyre S, Holder RL, Emery P: Generalised bone loss in patients with early rheumatoid arthritis. Lancet. 1994, 344: 23-27.PubMed
2.
go back to reference Celiker R, Gokce-Kutsal Y, Cindas A, Ariyurek M, Renda N, Koray Z, Basgoze O: Osteoporosis in rheumatoid arthritis: effect of disease activity. Clin Rheumatol. 1995, 14: 429-433.PubMed Celiker R, Gokce-Kutsal Y, Cindas A, Ariyurek M, Renda N, Koray Z, Basgoze O: Osteoporosis in rheumatoid arthritis: effect of disease activity. Clin Rheumatol. 1995, 14: 429-433.PubMed
3.
go back to reference Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJd: Population-based study of survival after osteoporotic fractures. Am J Epidemiol. 1993, 137: 1001-1005.PubMed Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJd: Population-based study of survival after osteoporotic fractures. Am J Epidemiol. 1993, 137: 1001-1005.PubMed
4.
go back to reference Hodgskinson R, Njeh CF, Currey JD, Langton CM: The ability of ultrasound velocity to predict the stiffness of cancellous bone in vitro. Bone. 1997, 21: 183-190. 10.1016/S8756-3282(97)00098-7.PubMed Hodgskinson R, Njeh CF, Currey JD, Langton CM: The ability of ultrasound velocity to predict the stiffness of cancellous bone in vitro. Bone. 1997, 21: 183-190. 10.1016/S8756-3282(97)00098-7.PubMed
5.
go back to reference Rice JC, Cowin SC, Bowman JA: On the dependence of the elasticity and strength of cancellous bone on apparent density. J Biomech . 1988, 21: 155-168.PubMed Rice JC, Cowin SC, Bowman JA: On the dependence of the elasticity and strength of cancellous bone on apparent density. J Biomech . 1988, 21: 155-168.PubMed
6.
go back to reference Ross PD, Davis JW, Vogel JM, Wasnich RD: A critical review of bone mass and the risk of fractures in osteoporosis. Calcif Tissue Int. 1990, 46: 149-161.PubMed Ross PD, Davis JW, Vogel JM, Wasnich RD: A critical review of bone mass and the risk of fractures in osteoporosis. Calcif Tissue Int. 1990, 46: 149-161.PubMed
7.
go back to reference Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM: Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993, 341: 72-75.PubMed Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM: Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993, 341: 72-75.PubMed
8.
go back to reference Marshall D, Johnell O, Wedel H: Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. Br Med J (Clin Res Ed). 1996, 312: 1254-1259. Marshall D, Johnell O, Wedel H: Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. Br Med J (Clin Res Ed). 1996, 312: 1254-1259.
9.
go back to reference Nevitt MC, Johnell O, Black DM, Ensrud K, Genant HK, Cummings SR: Bone mineral density predicts non-spine fractures in very elderly women. Study of Osteoporotic Fractures Research Group. Osteoporos Int. 1994, 4: 325-331.PubMed Nevitt MC, Johnell O, Black DM, Ensrud K, Genant HK, Cummings SR: Bone mineral density predicts non-spine fractures in very elderly women. Study of Osteoporotic Fractures Research Group. Osteoporos Int. 1994, 4: 325-331.PubMed
10.
go back to reference Nguyen T, Sambrook P, Kelly P, Jones G, Lord S, Freund J, Eisman J: Prediction of osteoporotic fractures by postural instability and bone density. Br Med J. 1993, 307: 1111-1115. Nguyen T, Sambrook P, Kelly P, Jones G, Lord S, Freund J, Eisman J: Prediction of osteoporotic fractures by postural instability and bone density. Br Med J. 1993, 307: 1111-1115.
11.
go back to reference Genant HK, Engelke K, Fuerst T, Gluer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M: Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res. 1996, 11: 707-730.PubMed Genant HK, Engelke K, Fuerst T, Gluer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M: Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res. 1996, 11: 707-730.PubMed
12.
go back to reference Njeh CF, Boivin CM, Langton CM: The role of ultrasound in the assessment of osteoporosis: a review. Osteoporos Int. 1997, 7: 7-22.PubMed Njeh CF, Boivin CM, Langton CM: The role of ultrasound in the assessment of osteoporosis: a review. Osteoporos Int. 1997, 7: 7-22.PubMed
13.
go back to reference Adams JE: Single and dual energy X-ray absorptiometry. Eur Radiol. 1997, 7 (Suppl 2): S20-S31. Adams JE: Single and dual energy X-ray absorptiometry. Eur Radiol. 1997, 7 (Suppl 2): S20-S31.
14.
go back to reference Lane NE, Jergas M, Genant HK: Osteoporosis and bone mineral assessment. In Arthritis and Allied Condition. a Textbook of Rheumatology. Edited by Koopman WJ. Baltimore: Williams & Wilkins;. 1997, 153-174. Lane NE, Jergas M, Genant HK: Osteoporosis and bone mineral assessment. In Arthritis and Allied Condition. a Textbook of Rheumatology. Edited by Koopman WJ. Baltimore: Williams & Wilkins;. 1997, 153-174.
15.
go back to reference Deodhar AA, Woolf AD: Bone mass measurement and bone metabolism in rheumatoid arthritis: a review. Br J Rheumatol. 1996, 35: 309-322.PubMed Deodhar AA, Woolf AD: Bone mass measurement and bone metabolism in rheumatoid arthritis: a review. Br J Rheumatol. 1996, 35: 309-322.PubMed
16.
go back to reference Verhoeven AC, Boers M: Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases. J Rheumatol. 1997, 24: 1495-1503.PubMed Verhoeven AC, Boers M: Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases. J Rheumatol. 1997, 24: 1495-1503.PubMed
17.
go back to reference Blake GM, Jagathesan T, Herd RJ, Fogelman I: Dual X-ray absorptiometry of the lumbar spine: the precision of paired anteroposterior/lateral studies. Br J Radiol. 1994, 67: 624-630.PubMed Blake GM, Jagathesan T, Herd RJ, Fogelman I: Dual X-ray absorptiometry of the lumbar spine: the precision of paired anteroposterior/lateral studies. Br J Radiol. 1994, 67: 624-630.PubMed
18.
go back to reference Hassager C, Jensen SB, Gotfredsen A, Christiansen C: The impact of measurement errors on the diagnostic value of bone mass measurements: theoretical considerations. Osteoporos Int. 1991, 1: 250-256.PubMed Hassager C, Jensen SB, Gotfredsen A, Christiansen C: The impact of measurement errors on the diagnostic value of bone mass measurements: theoretical considerations. Osteoporos Int. 1991, 1: 250-256.PubMed
19.
go back to reference van der Heijde DM: Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and applicability. Baillieres Clin Rheumatol. 1996, 10: 435-453.PubMed van der Heijde DM: Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and applicability. Baillieres Clin Rheumatol. 1996, 10: 435-453.PubMed
20.
go back to reference Scott DL, Coulton BL, Bacon PA, Popert AJ: Methods of X-ray assessment in rheumatoid arthritis: a re-evaluation. Br J Rheumatol. 1985, 24: 31-39.PubMed Scott DL, Coulton BL, Bacon PA, Popert AJ: Methods of X-ray assessment in rheumatoid arthritis: a re-evaluation. Br J Rheumatol. 1985, 24: 31-39.PubMed
21.
go back to reference Kaye JJ: Radiographic assessment of rheumatoid arthritis. Rheum Dis Clin North Am. 1995, 21: 395-406.PubMed Kaye JJ: Radiographic assessment of rheumatoid arthritis. Rheum Dis Clin North Am. 1995, 21: 395-406.PubMed
22.
go back to reference Jergas M, Uffmann M, Escher H, Glüer CC, Young KC, Grampp S, Köster O, Genant HK: Interobserver variation in the detection of osteopenia by radiography and comparison with dual x-ray absorptiometry (DXA) of the lumbar spine. Skeletal Radiol. 1994, 23: 195-199.PubMed Jergas M, Uffmann M, Escher H, Glüer CC, Young KC, Grampp S, Köster O, Genant HK: Interobserver variation in the detection of osteopenia by radiography and comparison with dual x-ray absorptiometry (DXA) of the lumbar spine. Skeletal Radiol. 1994, 23: 195-199.PubMed
23.
go back to reference Morgan DB, Spiers FW, Pulvertaft CN, Fourman P: The amount of bone in the metacarpal and phalanx according to age and sex. Clin Radiol. 1967, 18: 101-108.PubMed Morgan DB, Spiers FW, Pulvertaft CN, Fourman P: The amount of bone in the metacarpal and phalanx according to age and sex. Clin Radiol. 1967, 18: 101-108.PubMed
24.
go back to reference Yang SO, Hagiwara S, Engelke K, Dhillon MS, Guglielmi G, Bendavid EJ, Soejima O, Nelson DL, Genant HK: Radiographic absorptiometry for bone mineral measurement of the phalanges: precision and accuracy study. Radiology. 1994, 192: 857-859.PubMed Yang SO, Hagiwara S, Engelke K, Dhillon MS, Guglielmi G, Bendavid EJ, Soejima O, Nelson DL, Genant HK: Radiographic absorptiometry for bone mineral measurement of the phalanges: precision and accuracy study. Radiology. 1994, 192: 857-859.PubMed
25.
go back to reference Matsumoto C, Kushida K, Yamazaki K, Imose K, Inoue T: Metacarpal bone mass in normal and osteoporotic Japanese women using computed x-ray densitometry. Calcif Tissue Int. 1994, 54: 324-329. Matsumoto C, Kushida K, Yamazaki K, Imose K, Inoue T: Metacarpal bone mass in normal and osteoporotic Japanese women using computed x-ray densitometry. Calcif Tissue Int. 1994, 54: 324-329.
26.
go back to reference Kalebo P, Strid KG: Bone mass determination from microradiographs by computer-assisted videodensitometry. II: Aluminium as a reference substance. Acta Radiol. 1988, 29: 611-617.PubMed Kalebo P, Strid KG: Bone mass determination from microradiographs by computer-assisted videodensitometry. II: Aluminium as a reference substance. Acta Radiol. 1988, 29: 611-617.PubMed
27.
go back to reference Yates AJ, Ross PD, Lydick E, Epstein RS: Radiographic absorptiometry in the diagnosis of osteoporosis. Am J Med. 1995, 98: 41S-47S.PubMed Yates AJ, Ross PD, Lydick E, Epstein RS: Radiographic absorptiometry in the diagnosis of osteoporosis. Am J Med. 1995, 98: 41S-47S.PubMed
28.
go back to reference Kelly TL, Crane G, Baran DT: Single X-ray absorptiometry of the forearm: precision, correlation, and reference data. Calcif Tissue Int. 1994, 54: 212-218.PubMed Kelly TL, Crane G, Baran DT: Single X-ray absorptiometry of the forearm: precision, correlation, and reference data. Calcif Tissue Int. 1994, 54: 212-218.PubMed
29.
go back to reference Vogel JM, Wasnich RD, Ross PD: The clinical relevance of calcaneus bone mineral measurements: a review. Bone Miner. 1988, 5: 35-58.PubMed Vogel JM, Wasnich RD, Ross PD: The clinical relevance of calcaneus bone mineral measurements: a review. Bone Miner. 1988, 5: 35-58.PubMed
30.
go back to reference Suominen H, Heikkinen E, Vainio P, Lahtinen T: Mineral density of calcaneus in men at different ages: a population study with special reference to life-style factors. Age Ageing. 1984, 13: 273-281.PubMed Suominen H, Heikkinen E, Vainio P, Lahtinen T: Mineral density of calcaneus in men at different ages: a population study with special reference to life-style factors. Age Ageing. 1984, 13: 273-281.PubMed
31.
go back to reference Sim LH, van Doorn T: Radiographic measurement of bone mineral: reviewing dual energy X-ray absorptiometry. Australas Phys Eng Sci Med. 1995, 18: 65-80.PubMed Sim LH, van Doorn T: Radiographic measurement of bone mineral: reviewing dual energy X-ray absorptiometry. Australas Phys Eng Sci Med. 1995, 18: 65-80.PubMed
32.
go back to reference Blake GM, Wahner HW, Fogelman I: The Evaluation of Osteoporosis:. Dual Energy X-ray Absorptiometry and Ultrasound in Clinical Practice, edn 2. London: Martin Dunitz;. 1999 Blake GM, Wahner HW, Fogelman I: The Evaluation of Osteoporosis:. Dual Energy X-ray Absorptiometry and Ultrasound in Clinical Practice, edn 2. London: Martin Dunitz;. 1999
33.
go back to reference Kelly T, Slovick D, Schoenfield D, Neer R: Quantitative digital radiography versus dual photon absorptiometry of the lumbar spine. J Clin Endocr Metab. 1988, 67: 839-844.PubMed Kelly T, Slovick D, Schoenfield D, Neer R: Quantitative digital radiography versus dual photon absorptiometry of the lumbar spine. J Clin Endocr Metab. 1988, 67: 839-844.PubMed
34.
go back to reference Mazess R, Chesnut CHd, McClung M, Genant H: Enhanced precision with dual-energy X-ray absorptiometry. Calcif Tissue Int. 1992, 51: 14-17.PubMed Mazess R, Chesnut CHd, McClung M, Genant H: Enhanced precision with dual-energy X-ray absorptiometry. Calcif Tissue Int. 1992, 51: 14-17.PubMed
35.
go back to reference Blake GM, Parker JC, Buxton FM, Fogelman I: Dual X-ray absorptiometry: a comparison between fan beam and pencil beam scans. Br J Radiol. 1993, 66: 902-906.PubMed Blake GM, Parker JC, Buxton FM, Fogelman I: Dual X-ray absorptiometry: a comparison between fan beam and pencil beam scans. Br J Radiol. 1993, 66: 902-906.PubMed
36.
go back to reference Eiken P, Kolthoff N, Barenholdt O, Hermansen F, Pors Nielsen S: Switching from DXA pencil-beam to fan-beam. II: Studies in vivo. Bone. 1994, 15: 671-676.PubMed Eiken P, Kolthoff N, Barenholdt O, Hermansen F, Pors Nielsen S: Switching from DXA pencil-beam to fan-beam. II: Studies in vivo. Bone. 1994, 15: 671-676.PubMed
37.
go back to reference Shenstone BD, Mahmoud A, Woodward R, Elvins D, Palmer R, Ring F, Bhalla AK: Bone mineral density in nonsteroid treated early rheumatoid arthritis. Ann Rheum Dis. 1994, 53: 681-684.PubMedPubMedCentral Shenstone BD, Mahmoud A, Woodward R, Elvins D, Palmer R, Ring F, Bhalla AK: Bone mineral density in nonsteroid treated early rheumatoid arthritis. Ann Rheum Dis. 1994, 53: 681-684.PubMedPubMedCentral
38.
go back to reference Shenstone BD, Mahmoud A, Woodward R, Elvins D, Palmer R, Ring EF, Bhalla AK: Longitudinal bone mineral density changes in early rheumatoid arthritis. Br J Rheumatol. 1994, 33: 541-545.PubMed Shenstone BD, Mahmoud A, Woodward R, Elvins D, Palmer R, Ring EF, Bhalla AK: Longitudinal bone mineral density changes in early rheumatoid arthritis. Br J Rheumatol. 1994, 33: 541-545.PubMed
39.
go back to reference Peel NF, Spittlehouse AJ, Bax DE, Eastell R: Bone mineral density of the hand in rheumatoid arthritis. Arthritis Rheum. 1994, 37: 983-991.PubMed Peel NF, Spittlehouse AJ, Bax DE, Eastell R: Bone mineral density of the hand in rheumatoid arthritis. Arthritis Rheum. 1994, 37: 983-991.PubMed
40.
go back to reference van Schaardenburg D, Valkema R, Dijkmans BA, Papapoulos S, Zwinderman AH, Han KH, Pauwels EK, Breedveld FC: Prednisone treatment of elderly-onset rheumatoid arthritis. Disease activity and bone mass in comparison with chloroquine treatment. Arthritis Rheum. 1995, 38: 334-342.PubMed van Schaardenburg D, Valkema R, Dijkmans BA, Papapoulos S, Zwinderman AH, Han KH, Pauwels EK, Breedveld FC: Prednisone treatment of elderly-onset rheumatoid arthritis. Disease activity and bone mass in comparison with chloroquine treatment. Arthritis Rheum. 1995, 38: 334-342.PubMed
41.
go back to reference Mole PA, McMurdo ME, Paterson CR: Evaluation of peripheral dual energy X-ray absorptiometry: comparison with single photon absorptiometry of the forearm and dual energy X-ray absorptiometry of the spine or femur. Br J Radiol. 1998, 71: 427-432.PubMed Mole PA, McMurdo ME, Paterson CR: Evaluation of peripheral dual energy X-ray absorptiometry: comparison with single photon absorptiometry of the forearm and dual energy X-ray absorptiometry of the spine or femur. Br J Radiol. 1998, 71: 427-432.PubMed
42.
go back to reference Deodhar AA, Brabyn J, Jones PW, Davis MJ, Woolf AD: Measurement of hand bone mineral content by dual energy x-ray absorptiometry: development of the method, and its application in normal volunteers and in patients with rheumatoid arthritis. Ann Rheum Dis. 1994, 53: 685-690.PubMedPubMedCentral Deodhar AA, Brabyn J, Jones PW, Davis MJ, Woolf AD: Measurement of hand bone mineral content by dual energy x-ray absorptiometry: development of the method, and its application in normal volunteers and in patients with rheumatoid arthritis. Ann Rheum Dis. 1994, 53: 685-690.PubMedPubMedCentral
43.
go back to reference Devlin J, Lilley J, Gough A, Huissoon A, Holder R, Reece R, Perkins P, Emery P: Clinical associations of dual-energy X-ray absorptiometry measurement of hand bone mass in rheumatoid arthritis. Br J Rheumatol. 1996, 35: 1256-1262.PubMed Devlin J, Lilley J, Gough A, Huissoon A, Holder R, Reece R, Perkins P, Emery P: Clinical associations of dual-energy X-ray absorptiometry measurement of hand bone mass in rheumatoid arthritis. Br J Rheumatol. 1996, 35: 1256-1262.PubMed
44.
go back to reference Ozgocmen S, Karaoglan B, Kocakoc E, Ardicoglu O, Yorgancioglu ZR: Correlation of hand bone mineral density with the metacarpal cortical index and carpo:metacarpal ratio in patients with rheumatoid arthritis. Yonsei Med J. 1999, 40: 478-482.PubMed Ozgocmen S, Karaoglan B, Kocakoc E, Ardicoglu O, Yorgancioglu ZR: Correlation of hand bone mineral density with the metacarpal cortical index and carpo:metacarpal ratio in patients with rheumatoid arthritis. Yonsei Med J. 1999, 40: 478-482.PubMed
45.
go back to reference Deodhar AA, Brabyn J, Jones PW, Davis MJ, Woolf AD: Longitudinal study of hand bone densitometry in rheumatoid arthritis. Arthritis Rheum. 1995, 38: 1204-1210.PubMed Deodhar AA, Brabyn J, Jones PW, Davis MJ, Woolf AD: Longitudinal study of hand bone densitometry in rheumatoid arthritis. Arthritis Rheum. 1995, 38: 1204-1210.PubMed
46.
go back to reference Genant HK, Cann CE, Ettinger B, Gordan GS: Quantitative computed tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy. Ann Int Med. 1982, 97: 699-705.PubMed Genant HK, Cann CE, Ettinger B, Gordan GS: Quantitative computed tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy. Ann Int Med. 1982, 97: 699-705.PubMed
47.
go back to reference Guglielmi G, Grimston SK, Fischer KC, Pacifici R: Osteoporosis: Diagnosis with lateral and posteroanterior dual X-ray absorptiometry compared with quantitative CT. Radiology. 1994, 194: 845-850. Guglielmi G, Grimston SK, Fischer KC, Pacifici R: Osteoporosis: Diagnosis with lateral and posteroanterior dual X-ray absorptiometry compared with quantitative CT. Radiology. 1994, 194: 845-850.
48.
go back to reference Grampp S, Lang P, Jergas M, Gluer CC, Mathur A, Engelke K, Genant HK: Assessment of the skeletal status by peripheral quantitative computed tomography of the forearm: short-term precision in vivo and comparison to dual X-ray absorptiometry. J Bone Miner Res. 1995, 10: 1566-1576.PubMed Grampp S, Lang P, Jergas M, Gluer CC, Mathur A, Engelke K, Genant HK: Assessment of the skeletal status by peripheral quantitative computed tomography of the forearm: short-term precision in vivo and comparison to dual X-ray absorptiometry. J Bone Miner Res. 1995, 10: 1566-1576.PubMed
49.
go back to reference Takada M, Engelke K, Hagiwara S, Grampp S, Genant HK: Accuracy and precision study in vitro for peripheral quantitative computed tomography. Osteoporos Int. 1996, 6: 207-212.PubMed Takada M, Engelke K, Hagiwara S, Grampp S, Genant HK: Accuracy and precision study in vitro for peripheral quantitative computed tomography. Osteoporos Int. 1996, 6: 207-212.PubMed
50.
go back to reference Gluer CC, Jergas M, Hans D: Peripheral measurement techniques for the assessment of osteoporosis. Semin Nucl Med. 1997, 27: 229-247.PubMed Gluer CC, Jergas M, Hans D: Peripheral measurement techniques for the assessment of osteoporosis. Semin Nucl Med. 1997, 27: 229-247.PubMed
51.
go back to reference Laan RF, Buijs WC, van Erning LJ, Lemmens JA, Corstens FH, Ruijs SH, van de Putte LB, van Riel PL: Differential effects of glucocorticoids on cortical appendicular and cortical vertebral bone mineral content. Calcif Tissue Int. 1993, 52: 5-9.PubMed Laan RF, Buijs WC, van Erning LJ, Lemmens JA, Corstens FH, Ruijs SH, van de Putte LB, van Riel PL: Differential effects of glucocorticoids on cortical appendicular and cortical vertebral bone mineral content. Calcif Tissue Int. 1993, 52: 5-9.PubMed
52.
go back to reference Laan RF, van Riel PL, van Erning LJ, Lemmens JA, Ruijs SH, van de Putte LB: Vertebral osteoporosis in rheumatoid arthritis patients: effect of low dose prednisone therapy. Br J Rheumatol. 1992, 31: 91-96.PubMed Laan RF, van Riel PL, van Erning LJ, Lemmens JA, Ruijs SH, van de Putte LB: Vertebral osteoporosis in rheumatoid arthritis patients: effect of low dose prednisone therapy. Br J Rheumatol. 1992, 31: 91-96.PubMed
53.
go back to reference Laan RF, van Riel PL, van de Putte LB, van Erning LJ, van't Hof MA, Lemmens JA: Low-dose prednisone induces rapid reversible axial bone loss in patients with rheumatoid arthritis. A randomized, controlled study. Ann Intern Med. 1993, 119: 963-968.PubMed Laan RF, van Riel PL, van de Putte LB, van Erning LJ, van't Hof MA, Lemmens JA: Low-dose prednisone induces rapid reversible axial bone loss in patients with rheumatoid arthritis. A randomized, controlled study. Ann Intern Med. 1993, 119: 963-968.PubMed
54.
go back to reference Hans D, Schott AM, Meunier PJ: Ultrasonic assessment of bone: a review. Eur J Med. 1993, 2: 157-163.PubMed Hans D, Schott AM, Meunier PJ: Ultrasonic assessment of bone: a review. Eur J Med. 1993, 2: 157-163.PubMed
55.
go back to reference Gregg EW, Kriska AM, Salamone LM, Roberts MM, Anderson SJ, Ferrell RE, Kuller LH, Cauley JA: The epidemiology of quantitative ultrasound: a review of the relationships with bone mass, osteoporosis and fracture risk. Osteoporos Int. 1997, 7: 89-99.PubMed Gregg EW, Kriska AM, Salamone LM, Roberts MM, Anderson SJ, Ferrell RE, Kuller LH, Cauley JA: The epidemiology of quantitative ultrasound: a review of the relationships with bone mass, osteoporosis and fracture risk. Osteoporos Int. 1997, 7: 89-99.PubMed
56.
go back to reference Cheng S, Tylavsky F, Carbone L: Utility of ultrasound to assess risk of fracture. J Am Geriatr Soc. 1997, 45: 1382-1394.PubMed Cheng S, Tylavsky F, Carbone L: Utility of ultrasound to assess risk of fracture. J Am Geriatr Soc. 1997, 45: 1382-1394.PubMed
57.
go back to reference Hans D, Njeh CF, Genant HK, Meunier PJ: Quantitative ultrasound in bone status assessment. Rev Rhum Engl Ed. 1998, 65: 489-498.PubMed Hans D, Njeh CF, Genant HK, Meunier PJ: Quantitative ultrasound in bone status assessment. Rev Rhum Engl Ed. 1998, 65: 489-498.PubMed
58.
go back to reference Hans D, Srivastav SK, Singal C, Barkmann R, Njeh CF, Kantorovich E, Gluer CC, Genant HK: Does combining the results from multiple bone sites measured by a new quantitative ultrasound device improve discrimination of hip fracture?. J Bone Min Res. 1999, 14: 644-651. Hans D, Srivastav SK, Singal C, Barkmann R, Njeh CF, Kantorovich E, Gluer CC, Genant HK: Does combining the results from multiple bone sites measured by a new quantitative ultrasound device improve discrimination of hip fracture?. J Bone Min Res. 1999, 14: 644-651.
59.
go back to reference Bauer DC, Gluer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, Black DM: Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1997, 157: 629-634.PubMed Bauer DC, Gluer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, Black DM: Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1997, 157: 629-634.PubMed
60.
go back to reference Hans D, Dargent-Molina P, Schott AM, Sebert JL, Cormier C, Kotzki PO, Delmas PD, Pouilles JM, Breart G, Meunier PJ: Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet. 1996, 348: 511-514.PubMed Hans D, Dargent-Molina P, Schott AM, Sebert JL, Cormier C, Kotzki PO, Delmas PD, Pouilles JM, Breart G, Meunier PJ: Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet. 1996, 348: 511-514.PubMed
61.
go back to reference Pluijm SMF, Graafmans WC, Bouter LM, Lips P: Ultrasound measurements for the prediction of osteoporotic fractures in elderly people. Osteoporos Int. 1999, 9: 550-556. 10.1007/s001980050184.PubMed Pluijm SMF, Graafmans WC, Bouter LM, Lips P: Ultrasound measurements for the prediction of osteoporotic fractures in elderly people. Osteoporos Int. 1999, 9: 550-556. 10.1007/s001980050184.PubMed
62.
go back to reference Njeh CF, Boivin CM, Gardner-Medwin JM, Shaw NJ, Southwood TR: The use of finger ultrasound velocity to monitor bone status in juvenile chronic arthritis: a pilot study [abstract]. Osteoporos Int. 1997, 7: 300- Njeh CF, Boivin CM, Gardner-Medwin JM, Shaw NJ, Southwood TR: The use of finger ultrasound velocity to monitor bone status in juvenile chronic arthritis: a pilot study [abstract]. Osteoporos Int. 1997, 7: 300-
63.
go back to reference Madsen OR, Egsmose C, Hansen B, Sorensen OH: Soft tissue composition, quadriceps strength, bone quality and bone mass in rheumatoid arthritis. Clin Exp Rheumatol. 1998, 16: 27-32.PubMed Madsen OR, Egsmose C, Hansen B, Sorensen OH: Soft tissue composition, quadriceps strength, bone quality and bone mass in rheumatoid arthritis. Clin Exp Rheumatol. 1998, 16: 27-32.PubMed
64.
go back to reference Martin JC, Munro R, Campbell MK, Reid DM: Effects of disease and corticosteroids on appendicular bone mass in postmenopausal women with rheumatoid arthritis: comparison with axial measurements. Br J Rheumatol. 1997, 36: 43-49.PubMed Martin JC, Munro R, Campbell MK, Reid DM: Effects of disease and corticosteroids on appendicular bone mass in postmenopausal women with rheumatoid arthritis: comparison with axial measurements. Br J Rheumatol. 1997, 36: 43-49.PubMed
65.
go back to reference Daens S, Peretz A, de Maertelaer V, Moris M, Bergmann P: Efficiency of quantitative ultrasound measurements as compared with dualenergy X-ray absorptiometry in the assessment of corticosteroid-induced bone impairment. Osteoporos Int. 1999, 10: 278-283. 10.1007/s001980050227.PubMed Daens S, Peretz A, de Maertelaer V, Moris M, Bergmann P: Efficiency of quantitative ultrasound measurements as compared with dualenergy X-ray absorptiometry in the assessment of corticosteroid-induced bone impairment. Osteoporos Int. 1999, 10: 278-283. 10.1007/s001980050227.PubMed
66.
go back to reference Blanckaert F, Cortet B, Coquerelle P, Flipo RM, Duquesnoy B, Marchandise X, Delcambre B: Contribution of calcaneal ultrasonic assessment to the evaluation of postmenopausal and glucocorticoid-induced osteoporosis. Rev Rhumat Engl Ed. 1997, 64: 305-313. Blanckaert F, Cortet B, Coquerelle P, Flipo RM, Duquesnoy B, Marchandise X, Delcambre B: Contribution of calcaneal ultrasonic assessment to the evaluation of postmenopausal and glucocorticoid-induced osteoporosis. Rev Rhumat Engl Ed. 1997, 64: 305-313.
Metadata
Title
Bone loss: Quantitative imaging techniques for assessing bone mass in rheumatoid arthritis
Authors
Christopher F Njeh
Harry K Genant
Publication date
01-09-2000
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 6/2000
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar126

Other articles of this Issue 6/2000

Arthritis Research & Therapy 6/2000 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine