Following suboptimal stimulation through the T cell receptor, cells either undergo apoptosis or become anergic. Anergic cells have been shown to survive for extended periods in vivo, suggesting that anergic cells must be able to escape apoptosis. Previous studies have demonstrated that interferan (IFN)-βα can prevent T cell apoptosis induced by cytokine deprivation. This study aimed to show that IFN-βα is the major survival factor for anergic T cells. …
WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.
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