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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2000

01-12-2000 | Paper Report

IL-4 gene therapy for collagen arthritis

Author: Richard Brasington

Published in: Arthritis Research & Therapy | Issue 1/2000

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Excerpt

IL-4 is a regulatory cytokine which counteracts the effects of the major pro-inflammatory cytokines IL-1 and TNF-a. Levels of IL-4 are reduced in the synovium of patients with rheumatoid arthritis. Therefore, treatment to increase levels of IL-4 in such patients might be beneficial. Collagen-induced arthritis in mice resembles rheumatoid arthritis, with inflammatory synovitis producing cartilage and bone erosion. To introduce IL-4 via an adenovirus vector into mice with collagen arthritis, and assess the effect of this treatment on cartilage and bone erosion. …
Literature
1.
Lubberts E, Joosten LAB, Chabaud M, van Den Bersselaar L, Oppers B, Coenen-De Roo CJ, Richards CD, Miossec P, van Den Berg WB: IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. J Clin Invest. 2000, 105: 1697-1710.PubMedPubMedCentralCrossRef
Metadata
Title
IL-4 gene therapy for collagen arthritis
Author
Richard Brasington
Publication date
01-12-2000
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2000
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar-2000-66834

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Keynote webinar | Spotlight on medication adherence

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