Published in:
01-12-1999 | Paper Report
IgA anti-?2-glycoprotein I antibodies
Author:
Carrock Sewell
Published in:
Arthritis Research & Therapy
|
Issue 1/2000
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Excerpt
The anti phospholipid syndrome (APS) is characterised by clinical manifestations of thromboembolic phenomena, intra-uterine fetal loss and thrombocytopenia. APS is also associated with anti-phospholipid antibodies, which are autoantibodies directed against a modified ?2-glycoprotein I (?2-GPI). The modified structure is a result of interaction with anionic phospholipids. Although IgG, and to some extent IgM anti phospholipid antibodies are recognised as being of diagnostic significance, the role of IgA autoantibodies is not clear. This study examined the role of IgG, IgM and IgA isotype anti-?2-GPI in APS. To evaluate the prevalance of IgG, IgA and IgM anti-?2-GPI antibodies in APS, and to establish the clinical significance of IgA type antibodies compared with other isotypes. …
