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Open Access 01-12-2011 | Review

Erythropoietin (EPO) in acute kidney injury

Authors: Elizabeth Moore, Rinaldo Bellomo

Published in: Annals of Intensive Care | Issue 1/2011

Abstract

Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow. Accumulating evidence, however, suggests that EPO has additional organ protective effects, which may be useful in the prevention or treatment of acute kidney injury. These protective mechanisms are multifactorial in nature and include inhibition of apoptotic cell death, stimulation of cellular regeneration, inhibition of deleterious pathways, and promotion of recovery.

In this article, we review the physiology of EPO, assess previous work that supports the role of EPO as a general tissue protective agent, and explain the mechanisms by which it may achieve this tissue protective effect. We then focus on experimental and clinical data that suggest that EPO has a kidney protective effect.

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Title: Erythropoietin (EPO) in acute kidney injury
Authors: Elizabeth Moore
Rinaldo Bellomo
Publication date: 01-12-2011
Publisher: Springer Paris
Published in: Annals of Intensive Care / Issue 1/2011
Electronic ISSN: 2110-5820
DOI: https://doi.org/10.1186/2110-5820-1-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Erythropoietin (EPO) in acute kidney injury

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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