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Open Access 01-12-2014 | Research

Adherence influencing factors – a systematic review of systematic reviews

Authors: Tim Mathes, Thomas Jaschinski, Dawid Pieper

Published in: Archives of Public Health | Issue 1/2014

Abstract

Background

Non-adherence is widespread problem. Adherence is a crucial point for the success and the safe use of therapies. The objective of this overview (review of reviews) was to identify factors that influence adherence in chronic physical conditions.

Methods

A systematic literature search was performed in Medline and Embase (1990 to July 2013). Publications were screened according to predefined inclusion criteria. The study quality was assessed using AMSTAR. Both process steps were carried out independently by two reviewers. Relevant data on study characteristics and results were extracted in piloted standardized tables by one reviewer and checked by a second. Data were synthesized using a standardized quantitative approach by two reviewers.

Results

Seven systematic reviews were included. Higher education and employment seem to have a positive effect on adherence. Ethnic minorities seem to be less adherent. Co-payments and higher medication cost seems to have negative effect on adherence. In contrast financial status/income and marital status seem to have no influence on adherence. The effect of therapy related factors was mostly unclear or had no effect. Only the number of different medications in heart failure patients showed the tendency of an effect. Indicators of regime complexity showed consistently a negative effect direction. Duration of disease seems to have no effect on adherence. There is the tendency that higher or middle age is associated with higher adherence. But in more than half of the reviews the effect was unclear. There is no clear effect of physical as well as mental comorbidity. Only one review showed the tendency of an effect for mental comorbidity. Also for gender the effect is not clear because the effect direction was heterogenic between and within the systematic reviews.

Conclusion

The presented overview shows factors than can potentially have influence on adherence. Only for a few factors the influence on adherence was consistent. Most factors showed heterogeneous results regarding statistical significance and/or effect direction. However, belonging to an ethnic minority, unemployment and cost for the patient for their medications showed consistently a negative effect on adherence which indicates that there is a social gradient.

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Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, Wong PK: Medication compliance and persistence: terminology and definitions. Value Health: J Int Soc Pharmacoeconomics Outcomes Res. 2008, 11 (1): 44-47. 10.1111/j.1524-4733.2007.00213.x.CrossRef

Osterberg L, Blaschke T: Adherence to Medication. N Engl J Med. 2005, 353 (5): 487-497. 10.1056/NEJMra050100.CrossRefPubMed

World Health Organization: Adherence to long-term therapies: evidence for action. 2003, Geneva, Switzerland: World health Organization

The ABC Project team: Ascertaing barriers for compliance: policies for save, effective and cost-effective use medicines in Europe. Final report of the ABC project (Deliverable 71). 2012

DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW: Patient adherence and medical treatment outcomes: a meta-analysis. Med Care. 2002, 40 (9): 794-811. 10.1097/00005650-200209000-00009.CrossRefPubMed

Simpson SH, Eurich DT, Majumdar SR, Padwal RS, Tsuyuki RT, Varney J, Johnson JA: A meta-analysis of the association between adherence to drug therapy and mortality. BMJ. 2006, 333 (7557): 15-10.1136/bmj.38875.675486.55.CrossRefPubMedPubMedCentral

Mathes T, Pieper D, Antoine SL, Eikermann M: Adherence influencing factors in patients taking oral anticancer agents: a systematic review. Cancer Epidemiol. 2014, 38 (3): 214-226. 10.1016/j.canep.2014.03.012.CrossRefPubMed

Shea B, Grimshaw J, Wells G, Boers M, Andersson N, Hamel C, Porter A, Tugwell P, Moher D, Bouter L: Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007, 7 (1): 10-10.1186/1471-2288-7-10.CrossRefPubMedPubMedCentral

Shea BJ, Hamel C, Wells GA, Bouter LM, Kristjansson E, Grimshaw J, Henry DA, Boers M: AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol. 2009, 62 (10): 1013-1020. 10.1016/j.jclinepi.2008.10.009.CrossRefPubMed

10.

Grimshaw J, McAuley LM, Bero LA, Grilli R, Oxman AD, Ramsay C, Vale L, Zwarenstein M: Systematic reviews of the effectiveness of quality improvement strategies and programmes. Qual Saf Health Care. 2003, 12 (4): 298-303. 10.1136/qhc.12.4.298.CrossRefPubMedPubMedCentral

11.

Broekmans S, Dobbels F, Milisen K, Morlion B, Vanderschueren S: Medication adherence in patients with chronic non-malignant pain: is there a problem?. Eur J pain (Lond, Eng). 2009, 13 (2): 115-123. 10.1016/j.ejpain.2008.02.010.CrossRef

12.

Daley DJ, Myint PK, Gray RJ, Deane KH: Systematic review on factors associated with medication non-adherence in Parkinson’s disease. Parkinsonism Relat Disord. 2012, Epub 2012/10/02

13.

Oosterom-Calo R, van Ballegooijen AJ, Terwee CB, Te Velde SJ, Brouwer IA, Jaarsma T, Brug J: Determinants of adherence to heart failure medication: a systematic literature review. Heart Fail Rev. 2013, 18 (4): 409-427. 10.1007/s10741-012-9321-3.CrossRefPubMed

14.

Pasma A, Van’t Spijker A, Hazes JM, Busschbach JJ, Luime JJ: Factors associated with adherence to pharmaceutical treatment for rheumatoid arthritis patients: A systematic review. Semin Arthritis Rheum. 2013, Epub 2013/01/29

15.

Schrijvers LH, Uitslager N, Schuurmans MJ, Fischer K: Barriers and motivators of adherence to prophylactic treatment in haemophilia: a systematic review. Haemophilia: J World Federation Hemophilia. 2013, 19 (3): 355-361. 10.1111/hae.12079.CrossRef

16.

Sinnott SJ, Buckley C, O’Riordan D, Bradley C, Whelton H: The Effect of Copayments for Prescriptions on Adherence to Prescription Medicines in Publicly Insured Populations; A Systematic Review and Meta-Analysis. PLoS One. 2013, 8 (5):

17.

Verbrugghe M, Verhaeghe S, Lauwaert K, Beeckman D, Van Hecke A: Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: A systematic review. Cancer Treat Rev. 2013, 39 (6): 610-621. 10.1016/j.ctrv.2012.12.014.CrossRefPubMed

18.

Atkinson MJ, Petrozzino JJ: An evidence-based review of treatment-related determinants of patients’ nonadherence to HIV medications. AIDS Patient Care STDS. 2009, 23 (11): 903-914. 10.1089/apc.2009.0024.CrossRefPubMed

19.

Davies MJ, Gagliardino JJ, Gray LJ, Khunti K, Mohan V, Hughes R: Real-world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus: a systematic review. Diabet Med. 2013, 30 (5): 512-524. 10.1111/dme.12128.CrossRefPubMed

20.

Thorneloe RJ, Bundy C, Griffiths CE, Ashcroft DM, Cordingley L: Adherence to medication in patients with psoriasis: a systematic literature review. Br J Dermatol. 2013, 168 (1): 20-31. 10.1111/bjd.12039.CrossRefPubMed

21.

Dew MA, DiMartini AF, De Vito DA, Myaskovsky L, Steel J, Unruh M, Switzer GE, Zomak R, Kormos RL, Greenhouse JB: Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation. 2007, 83 (7): 858-873. 10.1097/01.tp.0000258599.65257.a6.CrossRefPubMed

22.

Jackson CA, Clatworthy J, Robinson A, Horne R: Factors associated with non-adherence to oral medication for inflammatory bowel disease: a systematic review. Am J Gastroenterol. 2010, 105 (3): 525-539. 10.1038/ajg.2009.685.CrossRefPubMed

23.

Gellad WF, Grenard J, McGlynn EA: A Review of Barriers to Medication Adherence: A Framework for Driving Policy Options. Technical report. Edited by: Corporation TR. 2009, Pittsburgh: RAND

24.

Hayden JA, Chou R, Hogg-Johnson S, Bombardier C: Systematic reviews of low back pain prognosis had variable methods and results: guidance for future prognosis reviews. J Clin Epidemiol. 2009, 62 (8): 781-796. 10.1016/j.jclinepi.2008.09.004. e781CrossRefPubMed

25.

Jepsen P, Johnsen SP, Gillman MW, Sorensen HT: Interpretation of observational studies. Heart. 2004, 90 (8): 956-960. 10.1136/hrt.2003.017269.CrossRefPubMedPubMedCentral

26.

Rothman K, Greenland S, Lash T: Modern epidemiology. 2008, Philadelphia: Lippincott Williams & Wilkins, 3

27.

Mathes T, Antoine S-L, Pieper D: Factors influencing adherence in Hepatitis-C infected patients: a systematic review. BMC Infect Dis. 2014, 14 (1): 203-10.1186/1471-2334-14-203.CrossRefPubMedPubMedCentral

28.

Vasamreddy CR, Dalal D, Dong JUN, Cheng A, Spragg D, Lamiy SZ, Meininger G, Henrikson CA, Marine JE, Berger R, Calkins H: Symptomatic and Asymptomatic Atrial Fibrillation in Patients Undergoing Radiofrequency Catheter Ablation. J Cardiovasc Electrophysiol. 2006, 17 (2): 134-139. 10.1111/j.1540-8167.2006.00359.x.CrossRefPubMed

29.

Lehane E, McCarthy G: Intentional and unintentional medication non-adherence: A comprehensive framework for clinical research and practice? A discussion paper. Int J Nurs Stud. 2007, 44 (8): 1468-1477. 10.1016/j.ijnurstu.2006.07.010.CrossRefPubMed

30.

Gadkari A, McHorney C: Unintentional non-adherence to chronic prescription medications: How unintentional is it really?. BMC Health Serv Res. 2012, 12 (1): 98-10.1186/1472-6963-12-98.CrossRefPubMedPubMedCentral

31.

Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, Dobbels F, Fargher E, Morrison V, Lewek P, Matyjaszczyk M, Mshelia C, Clyne W, Aronson JK: A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012, 73 (5): 691-705. 10.1111/j.1365-2125.2012.04167.x.CrossRefPubMedPubMedCentral

32.

Akerblad AC, Bengtsson F, Holgersson M, von Knorring L, Ekselius L: Identification of primary care patients at risk of nonadherence to antidepressant treatment. Patient Prefer Adherence. 2008, 2: 379-386.PubMedPubMedCentral

33.

Harmon G, Lefante J, Krousel-Wood M: Overcoming barriers: the role of providers in improving patient adherence to antihypertensive medications. Curr Opin Cardiol. 2006, 21 (4): 310-315. 10.1097/01.hco.0000231400.10104.e2.CrossRefPubMed

34.

Balfour L, Tasca GA, Kowal J, Corace K, Cooper CL, Angel JB, Garber G, Macpherson PA, Cameron DW: Development and validation of the HIV Medication Readiness Scale. Assessment. 2007, 14 (4): 408-416. 10.1177/1073191107304295.CrossRefPubMed

Title: Adherence influencing factors – a systematic review of systematic reviews
Authors: Tim Mathes
Thomas Jaschinski
Dawid Pieper
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Archives of Public Health / Issue 1/2014
Electronic ISSN: 2049-3258
DOI: https://doi.org/10.1186/2049-3258-72-37

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Adherence influencing factors – a systematic review of systematic reviews

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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