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Published in: Translational Neurodegeneration 1/2012

Open Access 01-12-2012 | Review

Current advances in using neurotrophic factors to treat neurodegenerative disorders

Authors: April M Weissmiller, Chengbiao Wu

Published in: Translational Neurodegeneration | Issue 1/2012

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Abstract

Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system. Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative disorders. However, significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic arena. This article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments.
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Metadata
Title
Current advances in using neurotrophic factors to treat neurodegenerative disorders
Authors
April M Weissmiller
Chengbiao Wu
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Translational Neurodegeneration / Issue 1/2012
Electronic ISSN: 2047-9158
DOI
https://doi.org/10.1186/2047-9158-1-14

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