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European Journal of Medical Research

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Open Access 01-12-2014 | Research

Left ventricular remodeling with preserved function after coronary microembolization: the effect of methylprednisolone

Authors: Jianying Ma, Juying Qian, Shufu Chang, Zhangwei Chen, Hang Jin, Mengsu Zeng, Yunzeng Zou, Junbo Ge

Published in: European Journal of Medical Research | Issue 1/2014

Abstract

Background

The objective of this study was to evaluate changes in left ventricular ejection fraction (LVEF) and left ventricular remodeling after coronary microembolization (CME) and to investigate the protective effects of methylprednisolone (MTP).

Methods

CME was induced by injection of microspheres (42 μm Dynospheres) into left anterior descending artery of mini swine. The animals were divided into two groups. Group 1 (n = 9) received 120,000 microspheres and Group 2 (n = 7) received 120,000 microspheres following intravenous administration of 30 mg/kg MTP. Contrast-enhanced magnetic resonance imaging (CeMRI) was performed at baseline, 6 h after intervention, and 1 week later.

Results

In Group 1, LVEF was significantly decreased at 6 h but recovered 1 week. This was accompanied by continuing left ventricular remodeling. In Group 2, LVEF remained unchanged at all assessment times. LVEF measured at 6 h and 1 week after CME in Group 1 and Group 2 was 0.39 ± 0.06 and 0.44 ± 0.04, and 0.44 ± 0.04 and 0.48 ± 0.03, respectively (Both P >0.05). Hyperenchancement at the anterior wall of the left ventricle was shown by MRI at 6 h in Group 1 but not in Group 2. The hyperenhanced area in Group 1 was 7.77 ± 1.49% of left ventricular mass.

Conclusions

The consequence of CME is left ventricular dilation with preserved LVEF. Pretreatment with MTP appears to have a cardioprotective effect on left ventricular remodeling.

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Title: Left ventricular remodeling with preserved function after coronary microembolization: the effect of methylprednisolone
Authors: Jianying Ma
Juying Qian
Shufu Chang
Zhangwei Chen
Hang Jin
Mengsu Zeng
Yunzeng Zou
Junbo Ge
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2014
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-19-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Left ventricular remodeling with preserved function after coronary microembolization: the effect of methylprednisolone

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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