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01-12-2010 | Review

Leptin receptors

Authors: E. Gorska, K. Popko, A. Stelmaszczyk-Emmel, O. Ciepiela, A. Kucharska, M. Wasik

Published in: European Journal of Medical Research | Special Issue 2/2010

Abstract

Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms. A long, fully active isoform of Ob-Rb is expressed mainly in the hypothalamus, where it takes part in energy homeostasis and in the regulation of secretory organs' activity. Ob-Rb is also present on all types of immune cells, involved in innate and adaptive immunity. Short leptin isoforms (Ob-Ra, Ob-Rc, Ob-Rd, and Ob-Re) that contain box 1 motif are able to bind JAK kinases (Janus kinases) as well as to activate some other signal transduction cascades. A soluble isoform (Ob-Re) can regulate serum leptin concentration and serve as a carrier protein delivering the hormone to its membrane receptors and is able to transduce the signal into the cell. JAK/STAT pathway plays the major role in leptin signal transduction through membrane receptors. Among all Ob-R isoforms, only full-length isoform (Ob-Rb) is able to fully transduce activation signal into the cell.

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Title: Leptin receptors
Authors: E. Gorska
K. Popko
A. Stelmaszczyk-Emmel
O. Ciepiela
A. Kucharska
M. Wasik
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue Special Issue 2/2010
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-15-S2-50

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Leptin receptors

Abstract

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Abstract

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