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Antimicrobial Resistance & Infection Control
Published in: Antimicrobial Resistance & Infection Control 1/2013

Open Access 01-12-2013 | Short report

No evidence so far for the dissemination of carbapenemase-producing Enterobactericeae in the community in Switzerland

Authors: Magdalena Nüesch-Inderbinen, Katrin Zurfluh, Herbert Hächler, Roger Stephan

Published in: Antimicrobial Resistance & Infection Control | Issue 1/2013

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Abstract

Background

Carbapenemase-producing Enterobacteriaceae represent an increasing threat to public health and to the treatment of serious nosocomial infections. The aim of this study was to screen for the presence of carbapenemase-producing Enterobacteriaceae in human carriers in community settings in Switzerland, a country representative of central Europe.

Findings

Three hundred and fourteen stool samples of healthy staff members of a meat-processing company and 291 fecal swabs from primary care patients were recovered in Switzerland between April 2012 and July 2012 and were tested for carbapenemase-producing Enterobacteriaceae isolates by selecting for growth on a carbapenem-containing selective medium. Six resulting isolates (5 Escherichia coli and 1 Citrobacter youngae) were subjected to antimicrobial susceptibility tests and PCR analysis by screening for the carbapenemase genes blaOXA-48, blaVIM, blaNDM-1, and blaKPC as well as for the extended-spectrum ß-lactamase genes blaTEM,blaSHV, blaCTX-M and blaCMY-2. No carbapenemase genes were detected. Resistance to ß-lactam antibiotics was due to carriage of the extended-spectrum ß-lactamase CTX-M-15 in 4 isolates, to CTX-M-14 in one further isolate and to the plasmidic AmpC-ß-lactamase CMY-2 in one isolate.

Conclusions

These results show that carbapenemase-producing Enterobacteriaceae are as yet not present in the community. Continuous surveillance is necessary to anticipate future trends in the prevalence and dissemination of carbapenem resistant isolates in the population.
Literature
1.
Akova M, Daikos GL, Tzouvelekis L, Carmeli Y: Interventional strategies and current clinical experience with carbapenemase-producing Gram-negative bacteria. Clin Microbiol Infect. 2012, 18: 439-448. 10.1111/j.1469-0691.2012.03823.x.CrossRefPubMed
2.
Ambler RP, Coulson AF, Frère JM, Ghuysen JM, Joris B, Forsman M, Levesque RC, Tiraby G, Waley SG: A standard numbering scheme for the class A beta-lactamases. Biochem J. 1991, 276: 269-PubMedCentralCrossRefPubMed
3.
Nordmann P, Naas T, Poirel L: Global spread of Carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2011, 17: 1791-1798. 10.3201/eid1710.110655.PubMedCentralCrossRefPubMed
4.
Grundmann H, Livermore DM, Giske CG, Canton R, Rossolini GM, Campos J, Vatopoulos A, Gniadkowski M, Toth A, Pfeifer Y, Jarlier V, Carmeli Y, CNSE Working Group: Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill. 2010, 15 (46):
5.
Filippini M, Masiero G, Moschetti K: Socioeconomic determinants of regional differences in outpatient antibiotic consumption: evidence from Switzerland. Health Policy. 2006, 78: 77-92. 10.1016/j.healthpol.2005.09.009.CrossRefPubMed
6.
Plüss-Suard C, Pannatier A, Kronenberg A, Mühlemann K, Zanetti G: Hospital antibiotic consumption in Switzerland: comparison of a multicultural country with Europe. J Hosp Infect. 2011, 79: 166-171. 10.1016/j.jhin.2011.05.028.CrossRefPubMed
7.
Poirel L, Lienhard R, Potron A, Malinverni R, Siegrist HH, Nordmann P: Plasmid-mediated carbapenem-hydrolysing β-lactamase KPC-2 in a Klebsiella pneumoniae isolate from Switzerland. J Antimicrob Chemother. 2011, 66: 675-676. 10.1093/jac/dkq499.CrossRefPubMed
8.
Babouee B, Widmer AF, Dubuis O, Ciardo D, Droz S, Betsch BY, Garzoni C, Führer U, Battegay M, Frei R, Goldenberger D: Emergence of four cases of KPC-2 and KPC-3-carrying Klebsiella pneumoniae introduced to Switzerland, 2009–10. Euro Surveill. 2011, 16 (11):
9.
Poirel L, Schrenzel J, Cherkaoui A, Bernabeu S, Renzi G, Nordmann P: Molecular analysis of NDM-1-producing enterobacterial isolates from Geneva, Switzerland. J Antimicrob Chemother. 2011, 66: 1730-1733. 10.1093/jac/dkr174.CrossRefPubMed
10.
Potron A, Schrenzel J, Poirel L, Renzi G, Cherkaoui A, Nordmann P: Emergence of OXA-48-producing Enterobacteriaceae in Switzerland. Int J Antimicrob Agents. 2012, 40: 563-564. 10.1016/j.ijantimicag.2012.07.003.CrossRefPubMed
11.
Nüesch-Inderbinen MT, Abgottspon H, Zurfluh K, Nüesch HJ, Stephan R, Hächler H: Cross-sectional study on fecal carriage of Enterobacteriaceae with resistance to extended-spectrum cephalosporins in primary care patients. Microb Drug Resist. 10.1089/mdr.2013.0013. in press
12.
Poirel L, Walsh TR, Cuvillier V, Nordmann P: Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis. 2011, 70: 119-123. 10.1016/j.diagmicrobio.2010.12.002.CrossRefPubMed
13.
Ellington MJ, Kistler J, Livermore DM, Woodford N: Multiplex PCR for rapid detection of genes encoding acquired metallo-β-lactamases. J Antimicrob Chemother. 2007, 59: 321-322.CrossRefPubMed
14.
Clinical and Laboratory Standards Institute: Twenty-first informational supplement, CLSI document M100-S21 2008. Performance standards for antimicrobial susceptibility testing. 2011, Wayne
15.
Geser N, Stephan R, Korczak BM, Beutin L, Hächler H: Molecular identification of extended-spectrum-β-lactamase genes from Enterobacteriaceae isolated from healthy human carriers in Switzerland. Antimicrob Agents Chemother. 2012, 56: 1609-1612. 10.1128/AAC.05539-11.PubMedCentralCrossRefPubMed
16.
Briñas L, Moreno MA, Zarazaga M, Porrero C, Sáenz Y, García M, Dominguez L, Torres C: Detection of CMY-2, CTX-M-14, and SHV-12 β-lactamases in Escherichia coli fecal-sample isolates from healthy chickens. Antimicrob Agents Chemother. 2003, 47: 2056-2058. 10.1128/AAC.47.6.2056-2058.2003.PubMedCentralCrossRefPubMed
17.
Endimiani A, Rossano A, Kunz D, Overesch G, Perreten V: First countrywide survey of third-generation cephalosporin-resistant Escherichia coli from broilers, swine, and cattle in Switzerland. Diagn Microbiol Infect Dis. 2012, 73: 31-38. 10.1016/j.diagmicrobio.2012.01.004.CrossRefPubMed
18.
Lartigue MF, Poirel L, Poyart C, Réglier-Poupet H, Nordmann P: Ertapenem resistance of Escherichia coli. Emerg Infect Dis. 2007, 13: 315-317. 10.3201/eid1302.060747.PubMedCentralCrossRefPubMed
19.
Stapleton PD, Shannon KP, French GL: Carbapenem resistance in Escherichia coli associated with plasmid-determined CMY-4 beta-lactamase production and loss of an outer membrane protein. Antimicrob Agents Chemother. 1999, 43: 1206-1210.PubMedCentralPubMed
Metadata
Title
No evidence so far for the dissemination of carbapenemase-producing Enterobactericeae in the community in Switzerland
Authors
Magdalena Nüesch-Inderbinen
Katrin Zurfluh
Herbert Hächler
Roger Stephan
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Antimicrobial Resistance & Infection Control / Issue 1/2013
Electronic ISSN: 2047-2994
DOI
https://doi.org/10.1186/2047-2994-2-23

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