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Open Access 01-12-2013 | Review

New evidence in trauma resuscitation - is 1:1:1 the answer?

Author: Timothy E Miller

Published in: Perioperative Medicine | Issue 1/2013

Abstract

Traumatic injury is a common problem, with over five million worldwide deaths from trauma per year. An estimated 10 to 20% of these deaths are potentially preventable with better control of bleeding. Damage control resuscitation involves early delivery of plasma and platelets as a primary resuscitation approach to minimize trauma-induced coagulopathy. Plasma, red blood cell and platelet ratios of 1:1:1 appear to be the best substitution for fresh whole blood; however, the current literature consists only of survivor bias-prone observational studies.

Holcomb JB, McMullin NR, Pearse L, Caruso J, Wade CE, Oetjen-Gerdes L, Champion HR, Lawnick M, Farr W, Rodriguez S, Butler FK: Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004. Annals of surgery. 2007, 245: 986-991. 10.1097/01.sla.0000259433.03754.98.PubMedCentralCrossRefPubMed

Holcomb JB: Optimal use of blood products in severely injured trauma patients. Hematology Am Soc Hematol Educ Program. 2010, 2010: 465-469. 10.1182/asheducation-2010.1.465.PubMedCentralCrossRefPubMed

Gruen RL, Jurkovich GJ, McIntyre LK, Foy HM, Maier RV: Patterns of errors contributing to trauma mortality: lessons learned from 2,594 deaths. Ann Surg. 2006, 244: 371-380.PubMedCentralPubMed

Como JJ, Dutton RP, Scalea TM, Edelman BB, Hess JR: Blood transfusion rates in the care of acute trauma. Transfusion. 2004, 44: 809-813. 10.1111/j.1537-2995.2004.03409.x.CrossRefPubMed

Malone DL, Hess JR, Fingerhut A: Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol. J Trauma. 2006, 60 (Suppl 6): S91-S96.CrossRefPubMed

Robertson OH: Transfusion with Preserved. Br Med J. 1918, 1: 691-695. 10.1136/bmj.1.2999.691.PubMedCentralCrossRefPubMed

Robertson OH: A method of citrated blood transfusion. Br Med J. 1918, 1: 477-479. 10.1136/bmj.1.2991.477.PubMedCentralCrossRefPubMed

Stansbury LG, Hess JR: Blood transfusion in World War I: the roles of Lawrence Bruce Robertson and Oswald Hope Robertson in the "most important medical advance of the war". Transfus Med Rev. 2009, 23: 232-236. 10.1016/j.tmrv.2009.03.007.CrossRefPubMed

Churchill ED: The surgical management of the wounded in the Mediterranean theater at the time of the fall of Rome-[Foreword by Brig. Gen'l Fred W. Rankin, M.C.]. Ann Surg. 1944, 120: 268-283. 10.1097/00000658-194409000-00002.PubMedCentralCrossRefPubMed

10.

Moore FA, McKinley BA, Moore EE: The next generation in shock resuscitation. Lancet. 2004, 363: 1988-1996. 10.1016/S0140-6736(04)16415-5.CrossRefPubMed

11.

Cotton BA, Guy JS, Morris JA, Abumrad NN: The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock. 2006, 26: 115-121. 10.1097/01.shk.0000209564.84822.f2.CrossRefPubMed

12.

Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, de Boisblanc B, Connors AF, Hite RD, Harabin AL: Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006, 354: 2564-2575.CrossRefPubMed

13.

Eddy VA, Morris JA, Cullinane DC: Hypothermia, coagulopathy, and acidosis. Surg Clin North Am. 2000, 80: 845-854. 10.1016/S0039-6109(05)70099-2.CrossRefPubMed

14.

Gando S: Disseminated intravascular coagulation in trauma patients. Semin Thromb Hemost. 2001, 27: 585-592. 10.1055/s-2001-18864.CrossRefPubMed

15.

Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF: Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008, 64: 1211-1217. 10.1097/TA.0b013e318169cd3c. discussion 1217CrossRefPubMed

16.

Shaz BH, Winkler AM, James AB, Hillyer CD, MacLeod JB: Pathophysiology of early trauma-induced coagulopathy: emerging evidence for hemodilution and coagulation factor depletion. J Trauma. 2011, 70: 1401-1407. 10.1097/TA.0b013e31821266e0.PubMedCentralCrossRefPubMed

17.

James MF, Michell WL, Joubert IA, Nicol AJ, Navsaria PH, Gillespie RS: Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma). Br J Anaesth. 2011, 107: 693-702. 10.1093/bja/aer229.CrossRefPubMed

18.

Ogilvie MP, Pereira BM, McKenney MG, McMahon PJ, Manning RJ, Namias N, Livingstone AS, Schulman CI, Proctor KG: First report on safety and efficacy of hetastarch solution for initial fluid resuscitation at a level 1 trauma center. J Am Coll Surg. 2010, 210: 870-880. 10.1016/j.jamcollsurg.2010.01.010. 880–872CrossRefPubMed

19.

Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB: The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007, 63: 805-813. 10.1097/TA.0b013e3181271ba3.CrossRefPubMed

20.

Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB: The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma. 2008, 64 (2 Supp): S79-S85. discussion S85CrossRefPubMed

21.

Spinella PC:Warm fresh whole blood transfusion for severe hemorrhage: U.S. military and potential civilian applications. Crit Care Med. 2008, 36 (7 Suppl): S340-S345.CrossRefPubMed

22.

Van PY, Sambasivan CN, Wade CE, Jones JA, Holcomb JB, Schreiber MA, Blackbourne LH: High transfusion ratios are not associated with increased complication rates in patients with severe extremity injuries. J Trauma. 2010, 69 (Suppl 1): S64-S68.CrossRefPubMed

23.

Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS: Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008, 248: 447-458.PubMed

24.

Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, Rosengart MR, Maier RV, Billiar TR, Peitzman AB, Moore EE: An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma. 2008, 65: 986-993. 10.1097/TA.0b013e3181878028.CrossRefPubMed

25.

Ho AM, Dion PW, Yeung JH, Holcomb JB, Critchley LA, Ng CS, Karmakar MK, Cheung CW, Rainer TH: Prevalence of survivor bias in observational studies on fresh frozen plasma:erythrocyte ratios in trauma requiring massive transfusion. Anesthesiology. 2012, 116: 716-728. 10.1097/ALN.0b013e318245c47b.CrossRefPubMed

26.

Sharpe JP, Weinberg JA, Magnotti LJ, Maclennan PA, Schroeppel TJ, Fabian TC, Croce MA: Accounting for differences in transfusion volume: Are all massive transfusions created equal?. J Trauma Acute Care Surg. 2012, 72: 1536-1540. 10.1097/TA.0b013e318251e253.CrossRefPubMed

27.

Perkins JG, Cap AP, Spinella PC, Blackbourne LH, Grathwohl KW, Repine TB, Ketchum L, Waterman P, Lee RE, Beekley AC, Sebesta JA, Shorr AF, Wade CE, Holcomb JB: An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients. J Trauma. 2009, 66 (4 Suppl): S77-S84. discussion S84-75CrossRefPubMed

28.

Shaz BH, Dente CJ, Nicholas J, MacLeod JB, Young AN, Easley K, Ling Q, Harris RS, Hillyer CD: Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. Transfusion. 2010, 50: 493-500. 10.1111/j.1537-2995.2009.02414.x.CrossRefPubMed

29.

Holcomb JB, Zarzabal LA, Michalek JE, Kozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE, Holcomb JB, Wade CE, Cotton BA, Kozar RA, Brasel KJ, Vercruysse GA, MacLeod JB, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat PC, Johannigamn JA, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, DeMoya MA, Trauma Outcomes Group: Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma. 2011, 71 (2 Suppl 3): S318-S328.CrossRefPubMed

30.

Armand R, Hess JR: Treating coagulopathy in trauma patients. Transfus Med Rev. 2003, 17: 223-231. 10.1016/S0887-7963(03)00022-1.CrossRefPubMed

31.

Tinmouth A, Fergusson D, Yee IC, Hebert PC: Clinical consequences of red cell storage in the critically ill. Transfusion. 2006, 46: 2014-2027. 10.1111/j.1537-2995.2006.01026.x.CrossRefPubMed

32.

Morse BC, Dente CJ, Hodgman EI, Shaz BH, Nicholas JM, Wyrzykowski AD, Salomone JP, Vercruysse GA, Rozycki GS, Feliciano DV: The effects of protocolized use of recombinant factor VIIa within a massive transfusion protocol in a civilian level I trauma center. Am Surg. 2011, 77: 1043-1049.PubMed

33.

Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B, CONTROL Study Group: Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma. 2010, 69: 489-500. 10.1097/TA.0b013e3181edf36e.CrossRefPubMed

34.

Levi M, Levy JH, Andersen HF, Truloff D: Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med. 2010, 363: 1791-1800. 10.1056/NEJMoa1006221.CrossRefPubMed

35.

Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010, 376: 23-32.CrossRefPubMed

36.

Schuster KM, Davis KA, Lui FY, Maerz LL, Kaplan LJ: The status of massive transfusion protocols in United States trauma centers: massive transfusion or massive confusion?. Transfusion. 2010, 50: 1545-1551. 10.1111/j.1537-2995.2010.02587.x.CrossRefPubMed

37.

Riskin DJ, Tsai TC, Riskin L, Hernandez-Boussard T, Purtill M, Maggio PM, Spain DA, Brundage SI: Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg. 2009, 209: 198-205. 10.1016/j.jamcollsurg.2009.04.016.CrossRefPubMed

38.

O'Keeffe T, Refaai M, Tchorz K, Forestner JE, Sarode R: A massive transfusion protocol to decrease blood component use and costs. Arch Surg. 2008, 143: 686-690. 10.1001/archsurg.143.7.686. discussion 690–681CrossRefPubMed

39.

Murad MH, Stubbs JR, Gandhi MJ, Wang AT, Paul A, Erwin PJ, Montori VM, Roback JD: The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis. Transfusion. 2010, 50: 1370-1383. 10.1111/j.1537-2995.2010.02630.x.CrossRefPubMed

40.

Lin Y, Saw CL, Hannach B, Goldman M: Transfusion-related acute lung injury prevention measures and their impact at Canadian Blood Services. Transfusion. 2012, 52: 567-574. 10.1111/j.1537-2995.2011.03330.x.CrossRefPubMed

41.

Dente CJ, Shaz BH, Nicholas JM, Harris RS, Wyrzykowski AD, Ficke BW, Vercruysse GA, Feliciano DV, Rozycki GS, Salomone JP, Ingram WL: Early predictors of massive transfusion in patients sustaining torso gunshot wounds in a civilian level I trauma center. J Trauma. 2010, 68: 298-304. 10.1097/TA.0b013e3181cf7f2a.CrossRefPubMed

42.

Johansson PI: Goal-directed hemostatic resuscitation for massively bleeding patients: the Copenhagen concept. Transfus Apher Sci. 2010, 43: 401-405. 10.1016/j.transci.2010.09.002.CrossRefPubMed

43.

Schochl H, Maegele M, Solomon C, Gorlinger K, Voelckel W: Early and individualized goal-directed therapy for trauma-induced coagulopathy. Scand J Trauma Resusc Emerg Med. 2012, 20: 15-10.1186/1757-7241-20-15.PubMedCentralCrossRefPubMed

44.

Rahbar MH, Fox EE, del Junco DJ, Cotton BA, Podbielski JM, Matijevic N, Cohen MJ, Schreiber MA, Zhang J, Mirhaji P, Duran SJ, Reynolds RJ, Benjamin-Garner R, Holcomb JB, PROMMTT Investigators: Coordination and management of multicenter clinical studies in trauma: experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study. Resuscitation. 2012, 83: 459-464. 10.1016/j.resuscitation.2011.09.019.PubMedCentralCrossRefPubMed

45.

Weiskopf RB: Reconstructing deconstructed blood for trauma. Anesthesiology. 2012, 116: 518-521. 10.1097/ALN.0b013e318245c494.CrossRefPubMed

Title: New evidence in trauma resuscitation - is 1:1:1 the answer?
Author: Timothy E Miller
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Perioperative Medicine / Issue 1/2013
Electronic ISSN: 2047-0525
DOI: https://doi.org/10.1186/2047-0525-2-13

Keynote webinar | Spotlight on medication adherence

Springer Medicine

New evidence in trauma resuscitation - is 1:1:1 the answer?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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