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Experimental & Translational Stroke Medicine

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Open Access 01-12-2010 | Research

Interleukin-18 does not influence infarct volume or functional outcome in the early stage after transient focal brain ischemia in mice

Authors: Stefan Braeuninger, Christoph Kleinschnitz, Guido Stoll

Published in: Experimental & Translational Stroke Medicine | Issue 1/2010

Abstract

Interleukin-18 (IL-18) is a proinflammatory cytokine of the interleukin-1 family which is upregulated after cerebral ischemia. The functional role of IL-18 in cerebral ischemia is unknown. In the present study, we compared infarct size in IL-18 knock-out and wild-type mice 24 hours and 48 hours after 1-hour transient middle cerebral artery occlusion (tMCAO). Moreover, the functional outcome was evaluated in a modified Bederson score, foot fault test and grip test. There were no significant differences in infarct size or functional outcome tests between wild-type and IL-18 knock-out mice. These data indicate that the early inflammatory response to cerebral ischemia does not involve IL-18, in contrast to other interleukin-1 family members such as interleukin-1.

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Title: Interleukin-18 does not influence infarct volume or functional outcome in the early stage after transient focal brain ischemia in mice
Authors: Stefan Braeuninger
Christoph Kleinschnitz
Guido Stoll
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Experimental & Translational Stroke Medicine / Issue 1/2010
Electronic ISSN: 2040-7378
DOI: https://doi.org/10.1186/2040-7378-2-1

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Interleukin-18 does not influence infarct volume or functional outcome in the early stage after transient focal brain ischemia in mice

Abstract

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Abstract

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