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Molecular Autism
Published in: Molecular Autism 1/2012

Open Access 01-12-2012 | Research

Vldlr overexpression causes hyperactivity in rats

Authors: Keiko Iwata, Nobuo Izumo, Hideo Matsuzaki, Takayuki Manabe, Yukiko Ishibashi, Yukio Ichitani, Kazuo Yamada, Ismail Thanseem, Ayyappan Anitha, Mahesh Mundalil Vasu, Chie Shimmura, Tomoyasu Wakuda, Yosuke Kameno, Taro Takahashi, Yasuhide Iwata, Katsuaki Suzuki, Kazuhiko Nakamura, Norio Mori

Published in: Molecular Autism | Issue 1/2012

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Abstract

Background

Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein receptors Vldlr and Lrp8. Reeler mutant mice display severe brain morphological defects and behavioral abnormalities. Several reports have implicated reelin signaling in the etiology of neurodevelopmental and psychiatric disorders, including autism, schizophrenia, bipolar disorder, and depression. Moreover, it has been reported that VLDLR mRNA levels are increased in the post-mortem brain of autistic patients.

Methods

We generated transgenic (Tg) rats overexpressing Vldlr, and examined their histological and behavioral features.

Results

Spontaneous locomotor activity was significantly increased in Tg rats, without detectable changes in brain histology. Additionally, Tg rats tended to show performance deficits in the radial maze task, suggesting that their spatial working memory was slightly impaired. Thus, Vldlr levels may be involved in determining locomotor activity and memory function.

Conclusions

Unlike reeler mice, patients with neurodevelopmental or psychiatric disorders do not show striking neuroanatomical aberrations. Therefore, it is notable, from a clinical point of view, that we observed behavioral phenotypes in Vldlr-Tg rats in the absence of neuroanatomical abnormalities.
Appendix
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Metadata
Title
Vldlr overexpression causes hyperactivity in rats
Authors
Keiko Iwata
Nobuo Izumo
Hideo Matsuzaki
Takayuki Manabe
Yukiko Ishibashi
Yukio Ichitani
Kazuo Yamada
Ismail Thanseem
Ayyappan Anitha
Mahesh Mundalil Vasu
Chie Shimmura
Tomoyasu Wakuda
Yosuke Kameno
Taro Takahashi
Yasuhide Iwata
Katsuaki Suzuki
Kazuhiko Nakamura
Norio Mori
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Molecular Autism / Issue 1/2012
Electronic ISSN: 2040-2392
DOI
https://doi.org/10.1186/2040-2392-3-11

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