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Open Access 01-12-2005 | Research

The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs

Authors: Jan Lubiński, Tomasz Huzarski, Grzegorz Kurzawski, Janina Suchy, Bartłomiej Masojć, Marek Mierzejewski, Marcin Lener, Wenancjusz Domagała, Maria Chosia, Urszula Teodorczyk, Krzysztof Mędrek, Tadeusz Dębniak, Elżbieta Złowocka, Jacek Gronwald, Tomasz Byrski, Ewa Grabowska, Katarzyna Nej, Anna Szymańska, Jolanta Szymańska, Joanna Matyjasik, Cezary Cybulski, Anna Jakubowska, Bohdan Górski, Steven A. Narod

Published in: Hereditary Cancer in Clinical Practice | Issue 2/2005

Abstract

The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the 3020insC allele of the NOD2 gene and cancer among 2604 cancer patients and 1910 controls from Poland. Patients were diagnosed with one of twelve types of cancer in the Szczecin region between 1994 and 2004. Significant associations were found for colon cancer (OR = 1.8; 95% CI 1.2 to 2.6), for lung cancer (OR = 1.7; 95% CI = 1.1 to 2.5) and for ovarian cancer (OR = 1.6; 95% CI 1.1 to 2.3). In addition, a significant association was found for early-onset laryngeal cancer (OR = 2.9; 95% CI 1.4 to 6.2) and for breast cancer in the presence of DCIS (OR = 2.1 95% CI = 1.2 to 3.6). The NOD2 3020insC allele is relatively common (in Poland 7.3% of individuals) and may be responsible for an important fraction of cancer cases. We estimate that the lifetime cancer risk among carriers of this allele is 30% higher than that of individuals with two wild-type alleles.

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Title: The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs
Authors: Jan Lubiński
Tomasz Huzarski
Grzegorz Kurzawski
Janina Suchy
Bartłomiej Masojć
Marek Mierzejewski
Marcin Lener
Wenancjusz Domagała
Maria Chosia
Urszula Teodorczyk
Krzysztof Mędrek
Tadeusz Dębniak
Elżbieta Złowocka
Jacek Gronwald
Tomasz Byrski
Ewa Grabowska
Katarzyna Nej
Anna Szymańska
Jolanta Szymańska
Joanna Matyjasik
Cezary Cybulski
Anna Jakubowska
Bohdan Górski
Steven A. Narod
Publication date: 01-12-2005
Publisher: BioMed Central
Published in: Hereditary Cancer in Clinical Practice / Issue 2/2005
Electronic ISSN: 1897-4287
DOI: https://doi.org/10.1186/1897-4287-3-2-59

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