Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Journal of Neurodevelopmental Disorders
Published in: Journal of Neurodevelopmental Disorders 1/2012

Open Access 01-12-2012 | Research

A cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome

Authors: Heather M Shapiro, Yukari Takarae, Danielle J Harvey, Margarita H Cabaral, Tony J Simon

Published in: Journal of Neurodevelopmental Disorders | Issue 1/2012

Login to get access

Abstract

Background

Chromosome 22q11.2 deletion syndrome (22q11.2DS) results from a 1.5- to 3-megabase deletion on the long arm of chromosome 22 and occurs in approximately 1 in 4000 live births. Previous studies indicate that children with 22q11.2DS are impaired on tasks involving spatial attention. However, the degree to which these impairments are due to volitionally generated (endogenous) or reflexive (exogenous) orienting of attention is unclear. Additionally, the efficacy of these component attention processes throughout child development in 22q11.2DS has yet to be examined.

Methods

Here we compared the performance of a wide age range (7 to 14 years) of children with 22q11.2DS to typically developing (TD) children on a comprehensive visual cueing paradigm to dissociate the contributions of endogenous and exogenous attentional impairments. Paired and two-sample t-tests were used to compare outcome measures within a group or between groups. Additionally, repeated measures regression models were fit to the data in order to examine effects of age on performance.

Results

We found that children with 22q11.2DS were impaired on a cueing task with an endogenous cue, but not on the same task with an exogenous cue. Additionally, it was younger children exclusively who were impaired on endogenous cueing when compared to age-matched TD children. Older children with 22q11.2DS performed comparably to age-matched TD peers on the endogenous cueing task.

Conclusions

These results suggest that endogenous but not exogenous orienting of attention is selectively impaired in children with 22q11.2DS. Additionally, the age effect on cueing in children with 22q11.2DS suggests a possible altered developmental trajectory of endogenous cueing.
Appendix
Available only for authorised users
Literature
1.
Carlson C, Sirotkin H, Pandita R, Goldberg R, McKie J, Wadey R, Patanjali SR, Weissman SM, Anyane-Yeboa K, Warburton D, Scambler P, Shprintzen R, Kucherlapati R, Morrow BE: Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients. Am J Hum Genet. 1997, 61: 620-629. 10.1086/515508.PubMedCentralCrossRefPubMed
2.
3.
Oskarsdottir S, Vujic M, Fasth A: Incidence and prevalence of the 22q11 deletion syndrome: a population-based study in Western Sweden. Arch Dis Child. 2004, 89: 148-151. 10.1136/adc.2003.026880.PubMedCentralCrossRefPubMed
4.
5.
Moss EM, Batshaw ML, Solot CB, Gerdes M, McDonald-McGinn DM, Driscoll DA, Emanuel BS, Zackai EH, Wang PP: Psychoeducational profile of the 22q11.2 microdeletion: A complex pattern. J Pediatr. 1999, 134: 193-198. 10.1016/S0022-3476(99)70415-4.CrossRefPubMed
6.
Wang PP, Woodin MF, Kreps-Falk R, Moss EM: Research on behavioral phenotypes: velocardiofacial syndrome (deletion 22q11.2). Dev Med Child Neurol. 2000, 42: 422-427. 10.1017/S0012162200000785.CrossRefPubMed
7.
Woodin M, Wang PP, Aleman D, McDonald-McGinn D, Zackai E, Moss E: Neuropsychological profile of children and adolescents with the 22q11.2 microdeletion. Genet Med. 2001, 3: 34-39. 10.1097/00125817-200101000-00008.CrossRefPubMed
8.
Simon TJ, Bearden CE, Mc-Ginn DM, Zackai E: Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome. Cortex. 2005, 41: 145-155. 10.1016/S0010-9452(08)70889-X.PubMedCentralCrossRefPubMed
9.
De Smedt B, Swillen A, Devriendt K, Fryns JP, Verschaffel L, Ghesquiere P: Mathematical disabilities in children with velo-cardio-facial syndrome. Neuropsychologia. 2007, 45: 885-895. 10.1016/j.neuropsychologia.2006.08.024.CrossRefPubMed
10.
De Smedt B, Swillen A, Verschaffel L, Ghesquiere P: Mathematical learning disabilities in children with 22q11.2 deletion syndrome: a review. Dev Disabil Res Rev. 2009, 15: 4-10. 10.1002/ddrr.44.CrossRefPubMed
11.
Simon TJ: A new account of the neurocognitive foundations of impairments in space, time and number processing in children with chromosome 22q11.2 deletion syndrome. Dev Disabil Res Rev. 2008, 14: 52-58. 10.1002/ddrr.8.PubMedCentralCrossRefPubMed
12.
13.
Kastner S, Ungerleider LG: Mechanisms of visual attention in the human cortex. Annu Rev Neurosci. 2000, 23: 315-341. 10.1146/annurev.neuro.23.1.315.CrossRefPubMed
14.
15.
Funes MJ, Lupianez J, Milliken B: The role of spatial attention and other processes on the magnitude and time course of cueing effects. Cogn Process. 2005, 6: 98-116. 10.1007/s10339-004-0038-7.CrossRefPubMed
16.
Jonides J, Irwin DE: Capturing attention. Cognition. 1981, 10: 145-150. 10.1016/0010-0277(81)90038-X.CrossRefPubMed
17.
Ristic J, Kingstone A: Rethinking attentional development: reflexive and volitional orienting in children and adults. Dev Sci. 2009, 12: 289-296. 10.1111/j.1467-7687.2008.00756.x.CrossRefPubMed
18.
Bearden CE, Woodin MF, Wang PP, Moss E, McDonald-McGinn D, Zackai E, Emannuel B, Cannon TD: The neurocognitive phenotype of the 22q11.2 deletion syndrome: selective deficit in visual-spatial memory. J Clin Exp Neuropsychol. 2001, 23: 447-464. 10.1076/jcen.23.4.447.1228.CrossRefPubMed
19.
Simon TJ, Bish JP, Bearden CE, Ding L, Ferrante S, Nguyen V, Gee JC, McDonald-McGinn DM, Zackai EH, Emanuel BS: A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children. Dev Psychopathol. 2005, 17: 753-784.PubMedCentralCrossRefPubMed
20.
Bish JP, Chiodo R, Mattei V, Simon TJ: Domain specific attentional impairments in children with chromosome 22q11.2 deletion syndrome. Brain Cogn. 2007, 64: 265-273. 10.1016/j.bandc.2007.03.007.PubMedCentralCrossRefPubMed
21.
Stoddard J, Beckett L, Simon TJ: Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome. J Neurodev Disord. 2011, 3: 76-85. 10.1007/s11689-010-9070-3.PubMedCentralCrossRefPubMed
22.
MacPherson AC, Klein RM, Moore C: Inhibition of return in children and adolescents. J Exp Child Psychol. 2003, 85: 337-351. 10.1016/S0022-0965(03)00104-8.CrossRefPubMed
23.
Harman C, Posner MI, Rothbart MK, Thomas-Thrapp L: Development of orienting to locations and objects in human infants. Can J Exp Psychol. 1994, 48: 301-318.CrossRefPubMed
24.
Brodeur DA, Enns JT: Covert visual orienting across the lifespan. Can J Exp Psychol. 1997, 51: 20-35.CrossRefPubMed
25.
Swanson J: School-Based Assessments and Interventions for ADD Students. 1992, Irvine, CA: KC Publishing
26.
Dennis M, Edelstein K, Copeland K, Frederick J, Francis DJ, Hetherington R, Blaser SE, Kramer LA, Drake JM, Brandt ME, Fletcher JM: Covert orienting to exogenous and endogenous cues in children with spina bifida. Neuropsychologia. 2005, 43: 976-987. 10.1016/j.neuropsychologia.2004.08.012.CrossRefPubMed
27.
Enns JT, Akhtar N: A developmental study of filtering in visual attention. Child Dev. 1989, 60: 1188-1199. 10.2307/1130792.CrossRefPubMed
28.
Simon TJ, Luck SJ: Attentional Impairments in Children with Chromosome 22q11.2 Deletion Syndrome. Cognitive Neuroscience of Attention. 2011, New York, NY: Guilford Press, 441-453. 2
29.
Ladavas E, Serino A: Action-dependent plasticity in peripersonal space representations. Cogn Neuropsychol. 2008, 25: 1099-1113. 10.1080/02643290802359113.CrossRef
30.
Gerdes M, Solot C, Wang PP, Moss E, LaRossa D, Randall P, Goldmuntz E, Clark BJ, Driscoll DA, Jawad A, Emanuel BS, McDonald-McGinn DM, Batshaw ML, Zackai EH: Cognitive and behavior profile of preschool children with chromosome 22q11.2 deletion. Am J Med Genet. 1999, 85: 127-133. 10.1002/(SICI)1096-8628(19990716)85:2<127::AID-AJMG6>3.0.CO;2-F.CrossRefPubMed
31.
Swillen A, Devriendt K, Legius E, Eyskens B, Dumoulin M, Gewillig M, Fryns JP: Intelligence and psychosocial adjustment in velocardiofacial syndrome: a study of 37 children and adolescents with VCFS. J Med Genet. 1997, 34: 453-458. 10.1136/jmg.34.6.453.PubMedCentralCrossRefPubMed
32.
Longo MR, Lourenco SF: Bisecting the mental number line in near and far space. Brain Cogn. 2010, 72: 362-367. 10.1016/j.bandc.2009.10.016.CrossRefPubMed
33.
Zorzi M, Priftis K, Meneghello F, Marenzi R, Umilta C: The spatial representation of numerical and non-numerical sequences: evidence from neglect. Neuropsychologia. 2006, 44: 1061-1067. 10.1016/j.neuropsychologia.2005.10.025.CrossRefPubMed
34.
Posner MI, Cohen Y: Components of visual orienting. Attention and Performance Vol X. Edited by: Bouma HB. 1984, Hillsdale, NJ: Erlbaum, 531-556.
35.
36.
Simon TJ, Ding L, Bish JP, McDonald-McGinn DM, Zackai EH, Gee J: Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study. Neuroimage. 2005, 25: 169-180. 10.1016/j.neuroimage.2004.11.018.CrossRefPubMed
37.
Eliez S, Schmitt JE, White CD, Reiss AL: Children and adolescents with velocardiofacial syndrome: a volumetric MRI study. Am J Psychiatry. 2000, 157: 409-415. 10.1176/appi.ajp.157.3.409.CrossRefPubMed
38.
Campbell LE, Daly E, Toal F, Stevens A, Azuma R, Catani M, Ng V, van Amelsvoort T, Chitnis X, Cutter W, Murphy DG, Murphy KC: Brain and behaviour in children with 22q11.2 deletion syndrome: a volumetric and voxel-based morphometry MRI study. Brain. 2006, 129: 1218-1228. 10.1093/brain/awl066.CrossRefPubMed
39.
Kates WR, Burnette CP, Jabs EW, Rutberg J, Murphy AM, Grados M, Geraghty M, Kaufmann WE, Pearlson GD: Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis. Biol Psychiatry. 2001, 49: 677-684. 10.1016/S0006-3223(00)01002-7.CrossRefPubMed
40.
Simon TJ, Wu Z, Avants B, Zhang H, Gee JC, Stebbins GT: Atypical cortical connectivity and visuospatial cognitive impairments are related in children with chromosome 22q11.2 deletion syndrome. Behav Brain Funct. 2008, 4: 25-10.1186/1744-9081-4-25.PubMedCentralCrossRefPubMed
41.
Barnea-Goraly N, Eliez S, Menon V, Bammer R, Reiss AL: Arithmetic ability and parietal alterations: a diffusion tensor imaging study in velocardiofacial syndrome. Brain Res Cogn Brain Res. 2005, 25: 735-740. 10.1016/j.cogbrainres.2005.09.013.CrossRefPubMed
42.
Srivastava S, Buonocore MH, Simon TJ: Atypical developmental trajectory of functionally significant cortical areas in children with chromosome 22q11.2 deletion syndrome. Hum Brain Mapp. 2012, 33: 213-223. 10.1002/hbm.21206.PubMedCentralCrossRefPubMed
43.
Corbetta M, Shulman GL: Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci. 2002, 3: 201-215.CrossRefPubMed
44.
van Amelsvoort T, Henry J, Morris R, Owen M, Linszen D, Murphy K, Murphy D: Cognitive deficits associated with schizophrenia in velo-cardio-facial syndrome. Schizophr Res. 2004, 70: 223-232. 10.1016/j.schres.2003.10.004.CrossRefPubMed
45.
Chow EW, Watson M, Young DA, Bassett AS: Neurocognitive profile in 22q11 deletion syndrome and schizophrenia. Schizophr Res. 2006, 87: 270-278. 10.1016/j.schres.2006.04.007.PubMedCentralCrossRefPubMed
46.
van Amelsvoort T, Daly E, Robertson D, Suckling J, Ng V, Critchley H, Owen MJ, Henry J, Murphy KC, Murphy DG: Structural brain abnormalities associated with deletion at chromosome 22q11: quantitative neuroimaging study of adults with velo-cardio-facial syndrome. Br J Psychiatry. 2001, 178: 412-419. 10.1192/bjp.178.5.412.CrossRefPubMed
47.
Chow EW, Zipursky RB, Mikulis DJ, Bassett AS: Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome. Biol Psychiatry. 2002, 51: 208-215. 10.1016/S0006-3223(01)01246-X.PubMedCentralCrossRefPubMed
48.
van Amelsvoort T, Daly E, Henry J, Robertson D, Ng V, Owen M, Murphy KC, Murphy DG: Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging study. Arch Gen Psychiatry. 2004, 61: 1085-1096. 10.1001/archpsyc.61.11.1085.CrossRefPubMed
49.
Gothelf D, Presburger G, Levy D, Nahmani A, Burg M, Berant M, Blieden LC, Finkelstein Y, Frisch A, Apter A, Weizman A: Genetic, developmental, and physical factors associated with attention deficit hyperactivity disorder in patients with velocardiofacial syndrome. Am J Med Genet B Neuropsychiatr Genet. 2004, 126B: 116-121. 10.1002/ajmg.b.20144.CrossRefPubMed
Metadata
Title
A cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome
Authors
Heather M Shapiro
Yukari Takarae
Danielle J Harvey
Margarita H Cabaral
Tony J Simon
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Neurodevelopmental Disorders / Issue 1/2012
Print ISSN: 1866-1947
Electronic ISSN: 1866-1955
DOI
https://doi.org/10.1186/1866-1955-4-5

Other articles of this Issue 1/2012

Journal of Neurodevelopmental Disorders 1/2012 Go to the issue

Review

Of mice and monkeys: using non-human primate models to bridge mouse- and human-based investigations of autism spectrum disorders

Research

Adolescents with prenatal cocaine exposure show subtle alterations in striatal surface morphology and frontal cortical volumes

Review

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Research

Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions

Research

Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study

Review

Social ‘wanting’ dysfunction in autism: neurobiological underpinnings and treatment implications