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Published in: Italian Journal of Pediatrics 1/2013

Open Access 01-12-2013 | Review

Allergic conjunctivitis: a comprehensive review of the literature

Authors: Mario La Rosa, Elena Lionetti, Michele Reibaldi, Andrea Russo, Antonio Longo, Salvatore Leonardi, Stefania Tomarchio, Teresio Avitabile, Alfredo Reibaldi

Published in: Italian Journal of Pediatrics | Issue 1/2013

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Abstract

Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety of ocular allergy treatment. An understanding of the immunologic mechanisms, clinical features, differential diagnosis, and treatment of ocular allergy may be useful to all specialists who deal with these patients. The purpose of this review is to systematically review literature underlining all the forms classified as ocular allergy: seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratocongiuntivitis, contact allergy, and giant papillary conjunctivitis.
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Literature
1.
go back to reference Rigoli L, Briuglia S, Caimmi S, Ferrau’ V, Gallizzi R, Leonardi S, La Rosa M, Salpietro C: Gene-environment interactions in childhood asthma. Int J Immunopathol Pharmacol. 2011, 24: 41-47.PubMed Rigoli L, Briuglia S, Caimmi S, Ferrau’ V, Gallizzi R, Leonardi S, La Rosa M, Salpietro C: Gene-environment interactions in childhood asthma. Int J Immunopathol Pharmacol. 2011, 24: 41-47.PubMed
2.
go back to reference Barbee RA, Kaltenborn W, Lebowitz MD, Burrows B: Longitudinal changes in allergen skin test reactivity in a community population sample. J Allergy Clin Immunol. 1987, 79: 16-24.CrossRefPubMed Barbee RA, Kaltenborn W, Lebowitz MD, Burrows B: Longitudinal changes in allergen skin test reactivity in a community population sample. J Allergy Clin Immunol. 1987, 79: 16-24.CrossRefPubMed
3.
go back to reference Maziak W, Behrens T, Brasky TM, Duhme H, Rzehak P, Weiland SK, Keil U: Are asthma and allergies in children and adolescents increasing. Results from ISAAC phase I and phase III surveys in Munster, Germany. Allergy. 2003, 58: 572-579. 10.1034/j.1398-9995.2003.00161.x.CrossRefPubMed Maziak W, Behrens T, Brasky TM, Duhme H, Rzehak P, Weiland SK, Keil U: Are asthma and allergies in children and adolescents increasing. Results from ISAAC phase I and phase III surveys in Munster, Germany. Allergy. 2003, 58: 572-579. 10.1034/j.1398-9995.2003.00161.x.CrossRefPubMed
4.
go back to reference Verlato G, Corsico A, Villani S, Cerveri I, Migliore E, Accordini S, Carolei A, Piccioni P, Bugiani M, Lo Cascio V, Marinoni A, Poli A, de Marco R: Is the prevalence of adult asthma and allergic rhinitis still increasing. Results of an Italian study. J Allergy Clin Immunol. 2003, 111: 1232-1238. 10.1067/mai.2003.1484.CrossRefPubMed Verlato G, Corsico A, Villani S, Cerveri I, Migliore E, Accordini S, Carolei A, Piccioni P, Bugiani M, Lo Cascio V, Marinoni A, Poli A, de Marco R: Is the prevalence of adult asthma and allergic rhinitis still increasing. Results of an Italian study. J Allergy Clin Immunol. 2003, 111: 1232-1238. 10.1067/mai.2003.1484.CrossRefPubMed
5.
go back to reference Leonardi S, del Giudice Miraglia M, La Rosa M, Bellanti JA: Atopic disease, immune system, and the environment. Allergy Asthma Proc. 2007, 28 (4): 410-417. 10.2500/aap.2007.28.2954.CrossRefPubMed Leonardi S, del Giudice Miraglia M, La Rosa M, Bellanti JA: Atopic disease, immune system, and the environment. Allergy Asthma Proc. 2007, 28 (4): 410-417. 10.2500/aap.2007.28.2954.CrossRefPubMed
6.
go back to reference Friedlander MH: Ocular Allergy. Curr Opin Allergy Clin Immunol. 2011, 11 (5): 477-482. 10.1097/ACI.0b013e32834a9652.CrossRef Friedlander MH: Ocular Allergy. Curr Opin Allergy Clin Immunol. 2011, 11 (5): 477-482. 10.1097/ACI.0b013e32834a9652.CrossRef
7.
go back to reference Bielory L, Frohman L: Allergic and immunologic disorders of the eye. J Allergy Clin Immunol. 1992, 86: 1-20.CrossRef Bielory L, Frohman L: Allergic and immunologic disorders of the eye. J Allergy Clin Immunol. 1992, 86: 1-20.CrossRef
9.
go back to reference Wong AH, Barg SS, Leung AK: Seasonal and perennial conjunctivitis. Recent Pat Inflamm Allergy Drug Discov. 2009, 3: 118-127. 10.2174/187221309788489733.CrossRefPubMed Wong AH, Barg SS, Leung AK: Seasonal and perennial conjunctivitis. Recent Pat Inflamm Allergy Drug Discov. 2009, 3: 118-127. 10.2174/187221309788489733.CrossRefPubMed
10.
11.
go back to reference Leonardi A, De Dominicis C, Motterle L: Immunopathogenesis of ocular allergy: a schematic approach to different clinical entities. Curr Opin Allergy Clin Immunol. 2007, 7 (5): 429-435. 10.1097/ACI.0b013e3282ef8674.CrossRefPubMed Leonardi A, De Dominicis C, Motterle L: Immunopathogenesis of ocular allergy: a schematic approach to different clinical entities. Curr Opin Allergy Clin Immunol. 2007, 7 (5): 429-435. 10.1097/ACI.0b013e3282ef8674.CrossRefPubMed
12.
go back to reference Leonardi A: The central role of conjunctival mast cells in the pathogenesis of ocular allergy. Curr Allergy Asthma Rep. 2002, 2 (4): 325-331. 10.1007/s11882-002-0061-7.CrossRefPubMed Leonardi A: The central role of conjunctival mast cells in the pathogenesis of ocular allergy. Curr Allergy Asthma Rep. 2002, 2 (4): 325-331. 10.1007/s11882-002-0061-7.CrossRefPubMed
13.
go back to reference Jun J, Bielory L, Raizman MB: Vernal conjunctivitis. Immunol All Clin North Am. 2008, 28: 59-82. 10.1016/j.iac.2007.12.007.CrossRef Jun J, Bielory L, Raizman MB: Vernal conjunctivitis. Immunol All Clin North Am. 2008, 28: 59-82. 10.1016/j.iac.2007.12.007.CrossRef
14.
go back to reference Kumar S: Vernal keratoconjunctivitis: a major review. Acta Ophthalmol. 2009, 87: 133-147. 10.1111/j.1755-3768.2008.01347.x.CrossRefPubMed Kumar S: Vernal keratoconjunctivitis: a major review. Acta Ophthalmol. 2009, 87: 133-147. 10.1111/j.1755-3768.2008.01347.x.CrossRefPubMed
15.
go back to reference Bremond-Gignac D, Donadieu J, Leonardi A, Pouliquen P, Doan S, Chiambarretta F, Montan P, Milazzo S, Hoang-Xuan T, Baudouin C, Aymé S: Prevalence of vernal keratoconjunctivitis: a rare disease?. Br J Ophthalmol. 2008, 92 (8): 1097-1102. 10.1136/bjo.2007.117812.CrossRefPubMed Bremond-Gignac D, Donadieu J, Leonardi A, Pouliquen P, Doan S, Chiambarretta F, Montan P, Milazzo S, Hoang-Xuan T, Baudouin C, Aymé S: Prevalence of vernal keratoconjunctivitis: a rare disease?. Br J Ophthalmol. 2008, 92 (8): 1097-1102. 10.1136/bjo.2007.117812.CrossRefPubMed
16.
go back to reference Ostler HB: Vernal conjunctivitis. Diseases of the external eye and adnexae: a text and atlas. 1st ed. Edited by: Ostler HB. 1993, Baltimore: Williams & Wilkins, 125- Ostler HB: Vernal conjunctivitis. Diseases of the external eye and adnexae: a text and atlas. 1st ed. Edited by: Ostler HB. 1993, Baltimore: Williams & Wilkins, 125-
17.
go back to reference Leonardi A, Secchi AG: Vernal keratoconjunctivitis. Int Ophthalmol Clin. 2003, 43 (1): 41-58. 10.1097/00004397-200343010-00007.CrossRefPubMed Leonardi A, Secchi AG: Vernal keratoconjunctivitis. Int Ophthalmol Clin. 2003, 43 (1): 41-58. 10.1097/00004397-200343010-00007.CrossRefPubMed
18.
go back to reference Bonini S, Coassin M, Aronni S, Lambiase A: Vernal keratoconjunctivitis. Eye (Lond). 2004, 18 (4): 345-351. 10.1038/sj.eye.6700675.CrossRef Bonini S, Coassin M, Aronni S, Lambiase A: Vernal keratoconjunctivitis. Eye (Lond). 2004, 18 (4): 345-351. 10.1038/sj.eye.6700675.CrossRef
19.
go back to reference Irani AM, Butrus SI, Tabbara KF, Schwartz LB: Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. J Allergy Clin Immunol. 1990, 86: 34-40. 10.1016/S0091-6749(05)80120-4.CrossRefPubMed Irani AM, Butrus SI, Tabbara KF, Schwartz LB: Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. J Allergy Clin Immunol. 1990, 86: 34-40. 10.1016/S0091-6749(05)80120-4.CrossRefPubMed
20.
go back to reference Ballow M, Mendelson L: Specific immunoglobulinE antibodies in tear secretions of patients with vernal conjunctivitis. J Allergy Clin Immuno. 1980, 66: 112-118. 10.1016/0091-6749(80)90057-3.CrossRef Ballow M, Mendelson L: Specific immunoglobulinE antibodies in tear secretions of patients with vernal conjunctivitis. J Allergy Clin Immuno. 1980, 66: 112-118. 10.1016/0091-6749(80)90057-3.CrossRef
21.
go back to reference Barney NP: Vernal and atopic keratoconjunctivitis. Cornea. Fundamentals, diagnosis, and management. Edited by: Krachmer JH, Mannis MJ, Holland EJ. 2011, St Louis: Mosby Elsevier, 573-3 Barney NP: Vernal and atopic keratoconjunctivitis. Cornea. Fundamentals, diagnosis, and management. Edited by: Krachmer JH, Mannis MJ, Holland EJ. 2011, St Louis: Mosby Elsevier, 573-3
22.
go back to reference Bielory B, Bielory L: Atopic dermatitis and keratoconjunctivitis. Immunol Allergy Clin North Am. 2010, 30: 323-336. 10.1016/j.iac.2010.06.004.CrossRefPubMed Bielory B, Bielory L: Atopic dermatitis and keratoconjunctivitis. Immunol Allergy Clin North Am. 2010, 30: 323-336. 10.1016/j.iac.2010.06.004.CrossRefPubMed
23.
go back to reference Guglielmetti S, Dart JK, Calder V: Atopic keratoconjunctivitis and atopic dermatitis. Curr Opin Allergy Clin Immunol. 2010, 10 (5): 478-485. 10.1097/ACI.0b013e32833e16e4.CrossRefPubMed Guglielmetti S, Dart JK, Calder V: Atopic keratoconjunctivitis and atopic dermatitis. Curr Opin Allergy Clin Immunol. 2010, 10 (5): 478-485. 10.1097/ACI.0b013e32833e16e4.CrossRefPubMed
24.
go back to reference Friedlaender MH: Contact allergy and toxicity in the eye. Int Ophthalmol Clin. 1998, 28: 317-320.CrossRef Friedlaender MH: Contact allergy and toxicity in the eye. Int Ophthalmol Clin. 1998, 28: 317-320.CrossRef
25.
go back to reference Niederkorn JY: Immune regulatory mechanisms in allergic conjunctivitis: insights from mouse models. Curr Opin Allergy Clin Immunol. 2008, 8: 472-476. 10.1097/ACI.0b013e32830edbcb.PubMedCentralCrossRefPubMed Niederkorn JY: Immune regulatory mechanisms in allergic conjunctivitis: insights from mouse models. Curr Opin Allergy Clin Immunol. 2008, 8: 472-476. 10.1097/ACI.0b013e32830edbcb.PubMedCentralCrossRefPubMed
26.
go back to reference Niederkorn JY, Chen PW, Mellon J, Stevens C, Mayhew E: Allergic conjunctivitis exacerbates corneal allograft rejection by activating Th1 and Th2 alloimmune responses. J Immunol. 2010, 184: 6076-6083. 10.4049/jimmunol.0902300.PubMedCentralCrossRefPubMed Niederkorn JY, Chen PW, Mellon J, Stevens C, Mayhew E: Allergic conjunctivitis exacerbates corneal allograft rejection by activating Th1 and Th2 alloimmune responses. J Immunol. 2010, 184: 6076-6083. 10.4049/jimmunol.0902300.PubMedCentralCrossRefPubMed
27.
go back to reference Mosmann TR, Coffman RL: Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989, 7: 145-173. 10.1146/annurev.iy.07.040189.001045.CrossRefPubMed Mosmann TR, Coffman RL: Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989, 7: 145-173. 10.1146/annurev.iy.07.040189.001045.CrossRefPubMed
28.
go back to reference Bielory L: Ocular allergy and dry eye syndrome. Curr Opin Allergy Clin Immunol. 2004, 4: 421-424. 10.1097/00130832-200410000-00014.CrossRefPubMed Bielory L: Ocular allergy and dry eye syndrome. Curr Opin Allergy Clin Immunol. 2004, 4: 421-424. 10.1097/00130832-200410000-00014.CrossRefPubMed
29.
go back to reference Oboki K, Ohno T, Saito H, Nakae S: Th17 and allergy. Allergol Int. 2008, 57: 121-134. 10.2332/allergolint.R-07-160.CrossRefPubMed Oboki K, Ohno T, Saito H, Nakae S: Th17 and allergy. Allergol Int. 2008, 57: 121-134. 10.2332/allergolint.R-07-160.CrossRefPubMed
30.
go back to reference Elhers WH, Donshik PC: Giant papillary conjunctivitis. Curr Opin Allergy Clin Immunol. 2008, 8: 445-449. 10.1097/ACI.0b013e32830e6af0.CrossRefPubMed Elhers WH, Donshik PC: Giant papillary conjunctivitis. Curr Opin Allergy Clin Immunol. 2008, 8: 445-449. 10.1097/ACI.0b013e32830e6af0.CrossRefPubMed
31.
go back to reference Forister JF, Forister EF, Yeung KK, Ye P, Chung MY, Tsui A, Weissman BA: Prevalence of contact lens-related complications: UCLA contact lens study. Eye Contact Lens. 2009, 35: 176-180. 10.1097/ICL.0b013e3181a7bda1.CrossRefPubMed Forister JF, Forister EF, Yeung KK, Ye P, Chung MY, Tsui A, Weissman BA: Prevalence of contact lens-related complications: UCLA contact lens study. Eye Contact Lens. 2009, 35: 176-180. 10.1097/ICL.0b013e3181a7bda1.CrossRefPubMed
32.
go back to reference Donshik PC, Ehlers WH, Ballow M: Giant papillary conjunctivitis. Immunol Allergy Clin North Am. 2008, 28 (1): 83-103. 10.1016/j.iac.2007.11.001.CrossRefPubMed Donshik PC, Ehlers WH, Ballow M: Giant papillary conjunctivitis. Immunol Allergy Clin North Am. 2008, 28 (1): 83-103. 10.1016/j.iac.2007.11.001.CrossRefPubMed
33.
go back to reference Rothman JS, Raizman MB, Friedlaender MH: Seasonal and perennial allergic conjunctivitis. Cornea. Fundamentals, diagnosis, and management. Edited by: Krachmer JH, Mannis MJ, Holland EJ. 2011, St Louis: Mosby Elsevier, 570-571. 3 Rothman JS, Raizman MB, Friedlaender MH: Seasonal and perennial allergic conjunctivitis. Cornea. Fundamentals, diagnosis, and management. Edited by: Krachmer JH, Mannis MJ, Holland EJ. 2011, St Louis: Mosby Elsevier, 570-571. 3
34.
go back to reference Stokes TC, Feinberg G: Rapid onset of action of levocabastine eye-drops in histamine-induced conjunctivitis. Clin Exp Allergy. 1993, 23: 791-794. 10.1111/j.1365-2222.1993.tb00368.x.CrossRefPubMed Stokes TC, Feinberg G: Rapid onset of action of levocabastine eye-drops in histamine-induced conjunctivitis. Clin Exp Allergy. 1993, 23: 791-794. 10.1111/j.1365-2222.1993.tb00368.x.CrossRefPubMed
35.
go back to reference Donshik PC, Pearlman D, Pinnas J, Raizman MB, Tauber J, Tinkelman D, Walters TR: Efficacy and safety of ketorolac tromethamine 0.5% and levocabastine 0.05%: a multicenter comparison in patients with seasonal allergic conjunctivitis. Adv Ther. 2000, 17: 94-102. 10.1007/BF02854842.CrossRefPubMed Donshik PC, Pearlman D, Pinnas J, Raizman MB, Tauber J, Tinkelman D, Walters TR: Efficacy and safety of ketorolac tromethamine 0.5% and levocabastine 0.05%: a multicenter comparison in patients with seasonal allergic conjunctivitis. Adv Ther. 2000, 17: 94-102. 10.1007/BF02854842.CrossRefPubMed
36.
go back to reference Leonardi S, Marchese G, Marseglia GL, La Rosa M: Montelukast in allergic diseases beyond asthma. Allergy Asthma Proc. 2007, 28 (3): 287-291. 10.2500/aap.2007.28.2955.CrossRefPubMed Leonardi S, Marchese G, Marseglia GL, La Rosa M: Montelukast in allergic diseases beyond asthma. Allergy Asthma Proc. 2007, 28 (3): 287-291. 10.2500/aap.2007.28.2955.CrossRefPubMed
37.
go back to reference Abelson MB, Paradis A, George MA, Smith LM, Maguire L, Burns R: Effects of Vasocon-A in the allergen challenge model of acute allergic conjunctivitis. Arch Ophthalmol. 1990, 108: 520-524. 10.1001/archopht.1990.01070060068051.CrossRefPubMed Abelson MB, Paradis A, George MA, Smith LM, Maguire L, Burns R: Effects of Vasocon-A in the allergen challenge model of acute allergic conjunctivitis. Arch Ophthalmol. 1990, 108: 520-524. 10.1001/archopht.1990.01070060068051.CrossRefPubMed
38.
go back to reference Mishra GP, Tamboli V, Jawla J, Mitra AK: Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis. Recent Pat Inflamm Allergy Drug Discov. 2011, 5: 26-36. 10.2174/187221311794474883.PubMedCentralCrossRefPubMed Mishra GP, Tamboli V, Jawla J, Mitra AK: Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis. Recent Pat Inflamm Allergy Drug Discov. 2011, 5: 26-36. 10.2174/187221311794474883.PubMedCentralCrossRefPubMed
39.
go back to reference Woerly G, Loiseau S, Loyens M, Schoch C, Capron M: Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils: Consequences for allergic eye diseases. Allergy. 2003, 58: 397-406. 10.1034/j.1398-9995.2003.00081.x.CrossRefPubMed Woerly G, Loiseau S, Loyens M, Schoch C, Capron M: Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils: Consequences for allergic eye diseases. Allergy. 2003, 58: 397-406. 10.1034/j.1398-9995.2003.00081.x.CrossRefPubMed
40.
go back to reference Nabe M, Miyagawa H, Agrawal DK, Sugiyama H, Townley RG: The effect of ketotifen on eosinophils as measured at LTC4 release and by chemotaxis. Allergy Proc. 1991, 12: 267-271. 10.2500/108854191778879313.CrossRefPubMed Nabe M, Miyagawa H, Agrawal DK, Sugiyama H, Townley RG: The effect of ketotifen on eosinophils as measured at LTC4 release and by chemotaxis. Allergy Proc. 1991, 12: 267-271. 10.2500/108854191778879313.CrossRefPubMed
41.
go back to reference Canonica GW, Ciprandi G, Petzold U, Kolb C, Ellers-Lenz B, Hermann R: Topical azelastine in perennial allergic conjunctivitis. Curr Med Res Opin. 2003, 19: 321-329. 10.1185/030079903125001794.CrossRefPubMed Canonica GW, Ciprandi G, Petzold U, Kolb C, Ellers-Lenz B, Hermann R: Topical azelastine in perennial allergic conjunctivitis. Curr Med Res Opin. 2003, 19: 321-329. 10.1185/030079903125001794.CrossRefPubMed
42.
go back to reference Bielory L, Lien KW, Bigelsen S: Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis. Drugs. 2005, 65: 215-228. 10.2165/00003495-200565020-00004.CrossRefPubMed Bielory L, Lien KW, Bigelsen S: Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis. Drugs. 2005, 65: 215-228. 10.2165/00003495-200565020-00004.CrossRefPubMed
44.
go back to reference Spector SL, Raizman MB: Conjunctivitis medicamentosa. J Allergy Clin Immunol. 1994, 94: 134-136. 10.1016/0091-6749(94)90081-7.CrossRefPubMed Spector SL, Raizman MB: Conjunctivitis medicamentosa. J Allergy Clin Immunol. 1994, 94: 134-136. 10.1016/0091-6749(94)90081-7.CrossRefPubMed
45.
go back to reference Dell SJ, Shulman DG, Lowry GM, Howes J: A controlled evaluation of the efficacy and safety of loteprednol etabonate in the prophylactic treatment of seasonal allergic conjunctivitis. Loteprednol Allergic Conjunctivitis Study Group. Am J Ophthalmol. 1997, 123: 791-797.CrossRefPubMed Dell SJ, Shulman DG, Lowry GM, Howes J: A controlled evaluation of the efficacy and safety of loteprednol etabonate in the prophylactic treatment of seasonal allergic conjunctivitis. Loteprednol Allergic Conjunctivitis Study Group. Am J Ophthalmol. 1997, 123: 791-797.CrossRefPubMed
46.
go back to reference Dell SJ, Lowry GM, Northcutt JA, Howes J, Novack GD, Hart K: A randomized, double-masked, placebo-controlled parallel study of 0.2% loteprednol etabonate in patients with seasonal allergic conjunctivitis. J Allergy Clin Immunol. 1998, 102: 251-255. 10.1016/S0091-6749(98)70094-6.CrossRefPubMed Dell SJ, Lowry GM, Northcutt JA, Howes J, Novack GD, Hart K: A randomized, double-masked, placebo-controlled parallel study of 0.2% loteprednol etabonate in patients with seasonal allergic conjunctivitis. J Allergy Clin Immunol. 1998, 102: 251-255. 10.1016/S0091-6749(98)70094-6.CrossRefPubMed
47.
go back to reference Fan DS, Yu CB, Chiu TY, Wong CY, Ng JS, Pang CP, Lam DS: Ocular-hypertensive and anti-inflammatory response to rimexolone therapy in children. Arch Ophthalmol. 2003, 121: 1716-1721. 10.1001/archopht.121.12.1716.CrossRefPubMed Fan DS, Yu CB, Chiu TY, Wong CY, Ng JS, Pang CP, Lam DS: Ocular-hypertensive and anti-inflammatory response to rimexolone therapy in children. Arch Ophthalmol. 2003, 121: 1716-1721. 10.1001/archopht.121.12.1716.CrossRefPubMed
48.
go back to reference Pflugfelder SC, Maskin SL, Anderson B, Chodosh J, Holland EJ, De Paiva CS, Bartels SP, Micuda T, Proskin HM, Vogel R: A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol. 2004, 138: 444-457. 10.1016/j.ajo.2004.04.052.CrossRefPubMed Pflugfelder SC, Maskin SL, Anderson B, Chodosh J, Holland EJ, De Paiva CS, Bartels SP, Micuda T, Proskin HM, Vogel R: A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol. 2004, 138: 444-457. 10.1016/j.ajo.2004.04.052.CrossRefPubMed
49.
go back to reference Comstock TL, Decory HH: Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012, Epub 2012 Mar 28 Comstock TL, Decory HH: Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012, Epub 2012 Mar 28
50.
go back to reference Noon L, Cantab BC: Prophylactic innoculation against hay fever. Lancet. 1911, 1: 1572-1574.CrossRef Noon L, Cantab BC: Prophylactic innoculation against hay fever. Lancet. 1911, 1: 1572-1574.CrossRef
51.
go back to reference Lowell FC, Franklin W: A double-blind study of the effectiveness and specificity of injection therapy in ragweed hay fever. N Engl J Med. 1965, 273: 675-679. 10.1056/NEJM196509232731302.CrossRefPubMed Lowell FC, Franklin W: A double-blind study of the effectiveness and specificity of injection therapy in ragweed hay fever. N Engl J Med. 1965, 273: 675-679. 10.1056/NEJM196509232731302.CrossRefPubMed
52.
go back to reference Moller C, Dreborg S: Cross-reactivity between deciduous trees during immunotherapy. I. In vivo results. Clin Allergy. 1986, 16: 135-143. 10.1111/j.1365-2222.1986.tb00757.x.CrossRefPubMed Moller C, Dreborg S: Cross-reactivity between deciduous trees during immunotherapy. I. In vivo results. Clin Allergy. 1986, 16: 135-143. 10.1111/j.1365-2222.1986.tb00757.x.CrossRefPubMed
53.
go back to reference Andersen NH, Jeppesen F, Schiøler T, Osterballe O: Treatment of hay fever with sodium cromoglycate, hyposensitization, or a combination. Allergy. 1987, 42: 343-351. 10.1111/j.1398-9995.1987.tb02220.x.CrossRefPubMed Andersen NH, Jeppesen F, Schiøler T, Osterballe O: Treatment of hay fever with sodium cromoglycate, hyposensitization, or a combination. Allergy. 1987, 42: 343-351. 10.1111/j.1398-9995.1987.tb02220.x.CrossRefPubMed
54.
go back to reference Winther L, Malling HJ, Moseholm L, Mosbech H: Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. I. Efficacy estimated by a model reducing the bias of annual differences in pollen counts. Allergy. 2000, 55 (9): 818-826. 10.1034/j.1398-9995.2000.00367.x.CrossRefPubMed Winther L, Malling HJ, Moseholm L, Mosbech H: Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. I. Efficacy estimated by a model reducing the bias of annual differences in pollen counts. Allergy. 2000, 55 (9): 818-826. 10.1034/j.1398-9995.2000.00367.x.CrossRefPubMed
55.
go back to reference Leonardi S, Vitaliti G, Marseglia GL, Caimmi D, Lionetti E, del Miraglia Giudice M, Salpietro C, Spicuzza L, Ciprandi G, La Rosa M: Function of the airway epithelium in asthma. J Biol Regul Homeost Agents. 2012, 26: 41-48. Leonardi S, Vitaliti G, Marseglia GL, Caimmi D, Lionetti E, del Miraglia Giudice M, Salpietro C, Spicuzza L, Ciprandi G, La Rosa M: Function of the airway epithelium in asthma. J Biol Regul Homeost Agents. 2012, 26: 41-48.
56.
go back to reference Durham SR, Walker SM, Varga EM, Jacobson MR, O’Brien F, Noble W, Till SJ, Hamid QA, Nouri-Aria KT: Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med. 1999, 341: 468-475. 10.1056/NEJM199908123410702.CrossRefPubMed Durham SR, Walker SM, Varga EM, Jacobson MR, O’Brien F, Noble W, Till SJ, Hamid QA, Nouri-Aria KT: Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med. 1999, 341: 468-475. 10.1056/NEJM199908123410702.CrossRefPubMed
58.
go back to reference Walker SM, Varney VA, Gaga M, Jacobson MR, Durham SR: Grass pollen immunotherapy: efficacy and safety during a 4-year follow-up study. Allergy. 1995, 50: 405-413. 10.1111/j.1398-9995.1995.tb01170.x.CrossRefPubMed Walker SM, Varney VA, Gaga M, Jacobson MR, Durham SR: Grass pollen immunotherapy: efficacy and safety during a 4-year follow-up study. Allergy. 1995, 50: 405-413. 10.1111/j.1398-9995.1995.tb01170.x.CrossRefPubMed
59.
go back to reference Moller C, Juto P, Dreborg S, Bjorksten B: Blood lymphocyte proliferation response to pollen extract as a monitor of immunotherapy. Allergy. 1984, 39: 291-296. 10.1111/j.1398-9995.1984.tb00865.x.CrossRefPubMed Moller C, Juto P, Dreborg S, Bjorksten B: Blood lymphocyte proliferation response to pollen extract as a monitor of immunotherapy. Allergy. 1984, 39: 291-296. 10.1111/j.1398-9995.1984.tb00865.x.CrossRefPubMed
60.
go back to reference La Rosa M, Lionetti E, Leonardi S, Salpietro A, Bianchi L, Salpietro C, Miraglia Del Giudice M, Ciprandi G, Marseglia GL: Specific immunotherapy in children: the evidence. Int J Immunopathol Pharmacol. 2011, 24 (4 Suppl): 69-78.PubMed La Rosa M, Lionetti E, Leonardi S, Salpietro A, Bianchi L, Salpietro C, Miraglia Del Giudice M, Ciprandi G, Marseglia GL: Specific immunotherapy in children: the evidence. Int J Immunopathol Pharmacol. 2011, 24 (4 Suppl): 69-78.PubMed
61.
go back to reference Winther L, Malling HJ, Mosbech H: Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. II. Side-effects. Allergy. 2000, 55: 827-835. 10.1034/j.1398-9995.2000.00368.x.CrossRefPubMed Winther L, Malling HJ, Mosbech H: Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. II. Side-effects. Allergy. 2000, 55: 827-835. 10.1034/j.1398-9995.2000.00368.x.CrossRefPubMed
62.
go back to reference Vitaliti G, Leonardi S, del Giudice Miraglia M, Salpietro A, Artusio L, Caimmi D, Arrigo T, Salpietro C, Ciprandi G, La Rosa M: Mucosal immunity and sublingual immunotherapy in respiratory disorders. J Biol Regul Homeost Agents. 2012, 26: 85-94. Vitaliti G, Leonardi S, del Giudice Miraglia M, Salpietro A, Artusio L, Caimmi D, Arrigo T, Salpietro C, Ciprandi G, La Rosa M: Mucosal immunity and sublingual immunotherapy in respiratory disorders. J Biol Regul Homeost Agents. 2012, 26: 85-94.
63.
go back to reference Juniper EF, Kline PA, Ramsdale EH, Hargreave FE: Comparison of the efficacy and side effects of aqueous steroid nasal spray (budesonide) and allergen-injection therapy (Pollinex-R) in the treatment of seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol. 1990, 85: 606-611. 10.1016/0091-6749(90)90100-I.CrossRefPubMed Juniper EF, Kline PA, Ramsdale EH, Hargreave FE: Comparison of the efficacy and side effects of aqueous steroid nasal spray (budesonide) and allergen-injection therapy (Pollinex-R) in the treatment of seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol. 1990, 85: 606-611. 10.1016/0091-6749(90)90100-I.CrossRefPubMed
64.
go back to reference Sabbah A, Hassoun S, Le Sellin J, André C, Sicard H: A double-blind, placebo-controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy. 1994, 49: 309-313. 10.1111/j.1398-9995.1994.tb02273.x.CrossRefPubMed Sabbah A, Hassoun S, Le Sellin J, André C, Sicard H: A double-blind, placebo-controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy. 1994, 49: 309-313. 10.1111/j.1398-9995.1994.tb02273.x.CrossRefPubMed
65.
go back to reference Donovan JP, Buckeridge DL, Briscoe MP, Clark RH, Day JH: Efficacy of immunotherapy to ragweed antigen tested by controlled antigen exposure. Ann Allergy Asthma Immunol. 1996, 77: 74-80. 10.1016/S1081-1206(10)63483-7.CrossRefPubMed Donovan JP, Buckeridge DL, Briscoe MP, Clark RH, Day JH: Efficacy of immunotherapy to ragweed antigen tested by controlled antigen exposure. Ann Allergy Asthma Immunol. 1996, 77: 74-80. 10.1016/S1081-1206(10)63483-7.CrossRefPubMed
66.
go back to reference Nevius JM, Abelson MB, Welch D: The ocular drying effect of oral antihistamines (Loratadine) in the normal population - an evaluation. Invest Ophthalmol Vis Sci. 1999, 40: S549- Nevius JM, Abelson MB, Welch D: The ocular drying effect of oral antihistamines (Loratadine) in the normal population - an evaluation. Invest Ophthalmol Vis Sci. 1999, 40: S549-
67.
go back to reference Welch D, Ousler GW, Nally LA, Abelson MB, Wilcox KA: Ocular drying associated with oral antihistamines (loratadine) in the normal population-an evaluation of exaggerated dose effect. Adv Exp Med Biol. 2002, 506: 1051-1055. 10.1007/978-1-4615-0717-8_47.CrossRefPubMed Welch D, Ousler GW, Nally LA, Abelson MB, Wilcox KA: Ocular drying associated with oral antihistamines (loratadine) in the normal population-an evaluation of exaggerated dose effect. Adv Exp Med Biol. 2002, 506: 1051-1055. 10.1007/978-1-4615-0717-8_47.CrossRefPubMed
68.
go back to reference Butrus S, Portela R: Ocular allergy: diagnosis and treatment. Ophthalmol Clin North Am. 2005, 18: 485-492.PubMed Butrus S, Portela R: Ocular allergy: diagnosis and treatment. Ophthalmol Clin North Am. 2005, 18: 485-492.PubMed
69.
go back to reference Bielory L, Katelaris CH, Lightman S, Naclerio RM: Treating the ocular component of allergic rhinoconjunctivitis and related eye disorders. MedGenMed. 2007, 9 (3): 35-PubMedCentralPubMed Bielory L, Katelaris CH, Lightman S, Naclerio RM: Treating the ocular component of allergic rhinoconjunctivitis and related eye disorders. MedGenMed. 2007, 9 (3): 35-PubMedCentralPubMed
70.
go back to reference Miraglia Del Giudice M, Marseglia A, Leonardi S, La Rosa M, Salpietro C, Brunese FP, Arrigo T, Perrone L: Allergic rhinitis and quality of life in children. Int J Immunopathol Pharmacol. 2011, 24 (4 Suppl): 25-28.PubMed Miraglia Del Giudice M, Marseglia A, Leonardi S, La Rosa M, Salpietro C, Brunese FP, Arrigo T, Perrone L: Allergic rhinitis and quality of life in children. Int J Immunopathol Pharmacol. 2011, 24 (4 Suppl): 25-28.PubMed
71.
go back to reference Abelson MB, Granet D: Ocular allergy in pediatric practice. Curr Allergy Asthma Rep. 2006, 6 (4): 306-311. 10.1007/s11882-006-0064-x.CrossRefPubMed Abelson MB, Granet D: Ocular allergy in pediatric practice. Curr Allergy Asthma Rep. 2006, 6 (4): 306-311. 10.1007/s11882-006-0064-x.CrossRefPubMed
Metadata
Title
Allergic conjunctivitis: a comprehensive review of the literature
Authors
Mario La Rosa
Elena Lionetti
Michele Reibaldi
Andrea Russo
Antonio Longo
Salvatore Leonardi
Stefania Tomarchio
Teresio Avitabile
Alfredo Reibaldi
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2013
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/1824-7288-39-18

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