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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2011

Open Access 01-12-2011 | Review

Exciting new advances in oral cancer diagnosis: avenues to early detection

Authors: Ravi Mehrotra, Dwijendra K Gupta

Published in: Head & Neck Oncology | Issue 1/2011

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Abstract

The prognosis for patients with oral squamous cell carcinoma remains poor in spite of advances in therapy of many other malignancies. Early diagnosis and treatment remains the key to improved patient survival. Because the scalpel biopsy for diagnosis is invasive and has potential morbidity, it is reserved for evaluating highly suspicious lesions and not for the majority of oral lesions which are clinically not suspicious. Furthermore, scalpel biopsy has significant interobserver and intraobserver variability in the histologic diagnosis of dysplasia. There is an urgent need to devise critical diagnostic tools for early detection of oral dysplasia and malignancy that are practical, noninvasive and can be easily performed in an out-patient set-up. Diagnostic tests for early detection include brush biopsy, toluidine blue staining, autofluorescence, salivary proteomics, DNA analysis, biomarkers and spectroscopy. This state of the art review critically examines these tests and assesses their value in identifying oral squamous cell carcinoma and its precursor lesions.
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1. Ravi Mehrotra MD,Ph.D,MIAC, Professor of Pathology, Division of Cytopathology, Moti Lal Nehru Medical College.2. Dwijendra K. Gupta,Ph.D. Professor of Biochemistry and Coordinator-Chair, Center of Bioinformatics, Institute of Interdisciplinary Studies, University of Allahabad, Allahabad India - Presently at University of Bologna, Italy
Metadata
Title
Exciting new advances in oral cancer diagnosis: avenues to early detection
Authors
Ravi Mehrotra
Dwijendra K Gupta
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2011
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-3-33

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