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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2010

Open Access 01-12-2010 | Research

Methicillin Resistant Staphylococcus Aureus Infection as a causative agent of fistula formation following total laryngectomy for advanced head & neck cancer

Authors: Jean-Pierre Jeannon, Ahmad Orabi, Argyris Manganaris, Ricard Simo

Published in: Head & Neck Oncology | Issue 1/2010

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Abstract

Aims

The purpose of this paper was to investigate the impact of Methicillin Resistant Staphylococcus Aureus (MRSA) infection in the aetiology of pharyngo-cutaneous fistula (PCF) formation following total laryngectomy for advanced laryngeal cancer.

Methods

This was a retrospective uncontrolled case study series of 31 consecutive patients based in a single institution tertiary referral head and neck oncology centre.

Results

Pharyngo-cutaneous fistulas (PCF) following total laryngectomy occurred in 10 (32%) patients. MRSA was identified in 80% of patients with a PCF compared to 9% of patients that did not develop a fistula (p = 0.0001255 Fisher exact test). MRSA infection (p = 0.00012) and previous radiotherapy (p = 0.00025) were the only significant factors found to be important in fistula formation on multivariate analysis. Post-operative infections such as cellulitis, chest infection and carotid fistula were also associated with MRSA infections.

Conclusion

MRSA infection following total laryngectomy for laryngeal cancer can lead to potential serious complications such as PCF. Patients who underwent total laryngectomy following radiotherapy failure are at a higher risk of acquiring MRSA.
Appendix
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Metadata
Title
Methicillin Resistant Staphylococcus Aureus Infection as a causative agent of fistula formation following total laryngectomy for advanced head & neck cancer
Authors
Jean-Pierre Jeannon
Ahmad Orabi
Argyris Manganaris
Ricard Simo
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2010
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-2-14

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