Skip to main content
Top
Published in: Head & Neck Oncology 1/2009

Open Access 01-12-2009 | Research

Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 9 years

Authors: Astrid LD Kruse, Klaus W Grätz

Published in: Head & Neck Oncology | Issue 1/2009

Login to get access

Abstract

Purpose

Metastases of squamous cell carcinoma of the tongue and the mouth floor have been well studied. Concerning maxilla squamous cell carcinomas, however, only a few studies have been performed. The question is whether a prophylactic neck dissection should be performed in these tumors.

Patients and Material

In the Department of Craniomaxillofacial Surgery at the University Hospital of Zurich, 30 patients who had been treated for squamous cell carcinonoma of the maxilla were examined retrospectively. Special attention was paid to direct and late metastasis, survival rate, and treatment.

Results

Of the 59 patients with upper jaw carcinomas over a 9-year period, only about half (30 patients) had a squamous cell carcinoma of the upper jaw. Of those patients, 27% had an upper lesion on the right side, 33% on the left. Of the 11 patients (36.7%) presenting positive lymph nodes, 4 patients had direct positive lymph nodes while 7 patients had later positive lymph nodes; and 71.4% of the late metastasis appeared during the first year.

Conclusion

Because of the 36.7% of patients presenting metastases in the cervical lymph nodes, elective neck treatment should be considered in cases even with a negative clinical examination.
Appendix
Available only for authorised users
Literature
1.
go back to reference Canto MT, Devesa SS: Oral cavity and pharynx cancer incidence rates in the United States, 1975–1998. Oral Oncol. 2002, 38 (6): 610-7. 10.1016/S1368-8375(01)00109-9.CrossRefPubMed Canto MT, Devesa SS: Oral cavity and pharynx cancer incidence rates in the United States, 1975–1998. Oral Oncol. 2002, 38 (6): 610-7. 10.1016/S1368-8375(01)00109-9.CrossRefPubMed
2.
go back to reference Kowalski LP, Bagietto R, Lara JR, Santos RL, Tagawa EK, Santos IR: Factors influencing contralateral lymph node metastasis from oral carcinoma. Head Neck. 1999, 21 (2): 104-10. 10.1002/(SICI)1097-0347(199903)21:2<104::AID-HED2>3.0.CO;2-L.CrossRefPubMed Kowalski LP, Bagietto R, Lara JR, Santos RL, Tagawa EK, Santos IR: Factors influencing contralateral lymph node metastasis from oral carcinoma. Head Neck. 1999, 21 (2): 104-10. 10.1002/(SICI)1097-0347(199903)21:2<104::AID-HED2>3.0.CO;2-L.CrossRefPubMed
3.
go back to reference Pimenta Amaral TM, Da Silva Freire AR, Carvalho AL, Pinto CA, Kowalski LP: Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth. Oral Oncol. 2004, 40 (8): 780-6. 10.1016/j.oraloncology.2003.10.009.CrossRefPubMed Pimenta Amaral TM, Da Silva Freire AR, Carvalho AL, Pinto CA, Kowalski LP: Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth. Oral Oncol. 2004, 40 (8): 780-6. 10.1016/j.oraloncology.2003.10.009.CrossRefPubMed
4.
go back to reference Haddadin KJ, Soutar DS, Oliver RJ, Webster MH, Robertson AG, MacDonald DG: Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck. 1999, 21 (6): 517-25. 10.1002/(SICI)1097-0347(199909)21:6<517::AID-HED4>3.0.CO;2-C.CrossRefPubMed Haddadin KJ, Soutar DS, Oliver RJ, Webster MH, Robertson AG, MacDonald DG: Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck. 1999, 21 (6): 517-25. 10.1002/(SICI)1097-0347(199909)21:6<517::AID-HED4>3.0.CO;2-C.CrossRefPubMed
5.
go back to reference Simental AA, Johnson JT, Myers EN: Cervical metastasis from squamous cell carcinoma of the maxillary alveolus and hard palate. Laryngoscope. 2006, 116 (9): 1682-4. 10.1097/01.mlg.0000233607.41540.28.CrossRefPubMed Simental AA, Johnson JT, Myers EN: Cervical metastasis from squamous cell carcinoma of the maxillary alveolus and hard palate. Laryngoscope. 2006, 116 (9): 1682-4. 10.1097/01.mlg.0000233607.41540.28.CrossRefPubMed
6.
go back to reference International Union Against Cancer: TNM classification of malignant tumors. 1987, Berlin: Springer-Verlag, 4 International Union Against Cancer: TNM classification of malignant tumors. 1987, Berlin: Springer-Verlag, 4
7.
go back to reference Kurokawa H, Yamashita Y, Takeda S, Zhang M, Fukuyama H, Takahashi T: Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue. Head Neck. 2002, 24 (8): 731-6. 10.1002/hed.10130.CrossRefPubMed Kurokawa H, Yamashita Y, Takeda S, Zhang M, Fukuyama H, Takahashi T: Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue. Head Neck. 2002, 24 (8): 731-6. 10.1002/hed.10130.CrossRefPubMed
8.
go back to reference Sparano A, Weinstein G, Chalian A, Yodul M, Weber R: Multivariate predictors of occult neck metastasis in early oral tongue cancer. Otolaryngol Head Neck Surg. 2004, 131 (4): 472-6. 10.1016/j.otohns.2004.04.008.CrossRefPubMed Sparano A, Weinstein G, Chalian A, Yodul M, Weber R: Multivariate predictors of occult neck metastasis in early oral tongue cancer. Otolaryngol Head Neck Surg. 2004, 131 (4): 472-6. 10.1016/j.otohns.2004.04.008.CrossRefPubMed
9.
go back to reference Wallwork BD, Anderson SR, Coman WB: Squamous cell carcinoma of the floor of the mouth: tumour thickness and the rate of cervical metastasis. ANZ J Surg. 2007, 77 (9): 761-4. 10.1111/j.1445-2197.2007.04219.x.CrossRefPubMed Wallwork BD, Anderson SR, Coman WB: Squamous cell carcinoma of the floor of the mouth: tumour thickness and the rate of cervical metastasis. ANZ J Surg. 2007, 77 (9): 761-4. 10.1111/j.1445-2197.2007.04219.x.CrossRefPubMed
10.
go back to reference Hiratsuka H, Miyakawa A, Nakamori K, Kido Y, Sunakawa H, Kohama G: Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer. 1997, 80 (3): 351-6. 10.1002/(SICI)1097-0142(19970801)80:3<351::AID-CNCR1>3.0.CO;2-V.CrossRefPubMed Hiratsuka H, Miyakawa A, Nakamori K, Kido Y, Sunakawa H, Kohama G: Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer. 1997, 80 (3): 351-6. 10.1002/(SICI)1097-0142(19970801)80:3<351::AID-CNCR1>3.0.CO;2-V.CrossRefPubMed
11.
go back to reference Kligerman J, Lima RA, Soares JR, Prado L, Dias FL, Freitas EQ, Olivatto LO: Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity. Am J Surg. 1994, 168 (5): 391-4. 10.1016/S0002-9610(05)80082-0.CrossRefPubMed Kligerman J, Lima RA, Soares JR, Prado L, Dias FL, Freitas EQ, Olivatto LO: Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity. Am J Surg. 1994, 168 (5): 391-4. 10.1016/S0002-9610(05)80082-0.CrossRefPubMed
12.
go back to reference Capote A, Escorial V, Muñoz-Guerra MF, Rodríguez-Campo FJ, Gamallo C, Naval L: Elective neck dissection in early-stage oral squamous cell carcinoma – does it influence recurrence and survival?. Head Neck. 2007, 29 (1): 3-11. 10.1002/hed.20482.CrossRefPubMed Capote A, Escorial V, Muñoz-Guerra MF, Rodríguez-Campo FJ, Gamallo C, Naval L: Elective neck dissection in early-stage oral squamous cell carcinoma – does it influence recurrence and survival?. Head Neck. 2007, 29 (1): 3-11. 10.1002/hed.20482.CrossRefPubMed
13.
go back to reference O'Brien CJ, Traynor SJ, McNeil E, McMahon JD, Chaplin JM: The use of clinical criteria alone in the management of the clinically negative neck among patients with squamous cell carcinoma of the oral cavity and oropharynx. Arch Otolaryngol Head Neck Surg. 2000, 126 (3): 360-5.CrossRefPubMed O'Brien CJ, Traynor SJ, McNeil E, McMahon JD, Chaplin JM: The use of clinical criteria alone in the management of the clinically negative neck among patients with squamous cell carcinoma of the oral cavity and oropharynx. Arch Otolaryngol Head Neck Surg. 2000, 126 (3): 360-5.CrossRefPubMed
14.
go back to reference Lim YC, Koo BS, Lee JS, Lim JY, Choi EC: Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope. 2006, 116 (7): 1148-52. 10.1097/01.mlg.0000217543.40027.1d.CrossRefPubMed Lim YC, Koo BS, Lee JS, Lim JY, Choi EC: Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope. 2006, 116 (7): 1148-52. 10.1097/01.mlg.0000217543.40027.1d.CrossRefPubMed
15.
go back to reference Lim YC, Lee JS, Koo BS, Kim SH, Kim YH, Choi EC: Treatment of contralateral N0 neck in early squamous cell carcinoma of the oral tongue: elective neck dissection versus observation. Laryngoscope. 2006, 116 (3): 461-5. 10.1097/01.mlg.0000195366.91395.9b.CrossRefPubMed Lim YC, Lee JS, Koo BS, Kim SH, Kim YH, Choi EC: Treatment of contralateral N0 neck in early squamous cell carcinoma of the oral tongue: elective neck dissection versus observation. Laryngoscope. 2006, 116 (3): 461-5. 10.1097/01.mlg.0000195366.91395.9b.CrossRefPubMed
16.
go back to reference Lim YC, Koo BS, Lee JS, Lim JY, Choi EC: Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope. 2006, 116 (7): 1148-52. 10.1097/01.mlg.0000217543.40027.1d.CrossRefPubMed Lim YC, Koo BS, Lee JS, Lim JY, Choi EC: Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope. 2006, 116 (7): 1148-52. 10.1097/01.mlg.0000217543.40027.1d.CrossRefPubMed
17.
go back to reference Brekel van den MW, Stel HV, Castelijns JA, Nauta JJ, Waal van der I, Valk J, Meyer CJ, Snow GB: Cervical lymph node metastasis: assessment of radiologic criteria. Radiology. 1990, 177 (2): 379-84.CrossRefPubMed Brekel van den MW, Stel HV, Castelijns JA, Nauta JJ, Waal van der I, Valk J, Meyer CJ, Snow GB: Cervical lymph node metastasis: assessment of radiologic criteria. Radiology. 1990, 177 (2): 379-84.CrossRefPubMed
18.
go back to reference Murakami R, Uozumi H, Hirai T, Nishimura R, Shiraishi S, Ota K, Murakami D, Tomiguchi S, Oya N, Katsuragawa S, Yamashita Y: Impact of FDG-PET/CT imaging on nodal staging for head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2007, 68 (2): 377-82. Epub 2007 Feb 22.CrossRefPubMed Murakami R, Uozumi H, Hirai T, Nishimura R, Shiraishi S, Ota K, Murakami D, Tomiguchi S, Oya N, Katsuragawa S, Yamashita Y: Impact of FDG-PET/CT imaging on nodal staging for head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2007, 68 (2): 377-82. Epub 2007 Feb 22.CrossRefPubMed
19.
go back to reference Ng SH, Yen TC, Liao CT, Chang JT, Chan SC, Ko SF, Wang HM, Wong HF: 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med. 2005, 46 (7): 1136-43.PubMed Ng SH, Yen TC, Liao CT, Chang JT, Chan SC, Ko SF, Wang HM, Wong HF: 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med. 2005, 46 (7): 1136-43.PubMed
20.
go back to reference Sigg MB, Steinert H, Grätz K, Hugenin P, Stoeckli S, Eyrich GK: Staging of head and neck tumors: [18F]fluorodeoxyglucose positron emission tomography compared with physical examination and conventional imaging modalities. J Oral Maxillofac Surg. 2003, 61 (9): 1022-9. 10.1016/S0278-2391(03)00314-8.CrossRefPubMed Sigg MB, Steinert H, Grätz K, Hugenin P, Stoeckli S, Eyrich GK: Staging of head and neck tumors: [18F]fluorodeoxyglucose positron emission tomography compared with physical examination and conventional imaging modalities. J Oral Maxillofac Surg. 2003, 61 (9): 1022-9. 10.1016/S0278-2391(03)00314-8.CrossRefPubMed
21.
go back to reference Jeong HS, Baek CH, Son YI, Ki Chung M, Kyung Lee D, Young Choi J, Kim BT, Kim HJ: Use of integrated 18F-FDG PET/CT to improve the accuracy of initial cervical nodal evaluation in patients with head and neck squamous cell carcinoma. Head Neck. 2007, 29 (3): 203-10. 10.1002/hed.20504.CrossRefPubMed Jeong HS, Baek CH, Son YI, Ki Chung M, Kyung Lee D, Young Choi J, Kim BT, Kim HJ: Use of integrated 18F-FDG PET/CT to improve the accuracy of initial cervical nodal evaluation in patients with head and neck squamous cell carcinoma. Head Neck. 2007, 29 (3): 203-10. 10.1002/hed.20504.CrossRefPubMed
22.
go back to reference Wild D, Eyrich GK, Ciernik IF, Stoeckli SJ, Schuknecht B, Goerres GW: In-line (18)F-fluorodeoxyglucose positron emission tomography with computed tomography (PET/CT) in patients with carcinoma of the sinus/nasal area and orbit. J Craniomaxillofac Surg. 2006, 34 (1): 9-16. Epub 2005 Dec 15.CrossRefPubMed Wild D, Eyrich GK, Ciernik IF, Stoeckli SJ, Schuknecht B, Goerres GW: In-line (18)F-fluorodeoxyglucose positron emission tomography with computed tomography (PET/CT) in patients with carcinoma of the sinus/nasal area and orbit. J Craniomaxillofac Surg. 2006, 34 (1): 9-16. Epub 2005 Dec 15.CrossRefPubMed
23.
go back to reference Devaney KO, Rinaldo A, Rodrigo JP, Ferlito A: Sentinel node biopsy and head and neck tumors – where do we stand today?. Head Neck. 2006, 28 (12): 1122-31. 10.1002/hed.20443.CrossRefPubMed Devaney KO, Rinaldo A, Rodrigo JP, Ferlito A: Sentinel node biopsy and head and neck tumors – where do we stand today?. Head Neck. 2006, 28 (12): 1122-31. 10.1002/hed.20443.CrossRefPubMed
24.
go back to reference Ferlito A, Rinaldo A, Silver CE, Shah JP, Suárez C, Medina JE, Kowalski LP, Johnson JT, Strome M, Rodrigo JP, Werner JA, Takes RP, Towpik E, Robbins KT, Leemans CR, Herranz J, Gavilán J, Shaha AR, Wei WI: Neck dissection: then and now. Auris Nasus Larynx. 2006, 33 (4): 365-74. 10.1016/j.anl.2006.06.001. Epub 2006 Aug 4.CrossRefPubMed Ferlito A, Rinaldo A, Silver CE, Shah JP, Suárez C, Medina JE, Kowalski LP, Johnson JT, Strome M, Rodrigo JP, Werner JA, Takes RP, Towpik E, Robbins KT, Leemans CR, Herranz J, Gavilán J, Shaha AR, Wei WI: Neck dissection: then and now. Auris Nasus Larynx. 2006, 33 (4): 365-74. 10.1016/j.anl.2006.06.001. Epub 2006 Aug 4.CrossRefPubMed
25.
go back to reference Elsheikh MN, Rinaldo A, Hamakawa H, Mahfouz ME, Rodrigo JP, Brennan J, Devaney KO, Grandis JR, Ferlito A: Importance of molecular analysis in detecting cervical lymph node metastasis in head and neck squamous cell carcinoma. Head Neck. 2006, 28 (9): 842-9. 10.1002/hed.20368.CrossRefPubMed Elsheikh MN, Rinaldo A, Hamakawa H, Mahfouz ME, Rodrigo JP, Brennan J, Devaney KO, Grandis JR, Ferlito A: Importance of molecular analysis in detecting cervical lymph node metastasis in head and neck squamous cell carcinoma. Head Neck. 2006, 28 (9): 842-9. 10.1002/hed.20368.CrossRefPubMed
Metadata
Title
Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 9 years
Authors
Astrid LD Kruse
Klaus W Grätz
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2009
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-1-28

Other articles of this Issue 1/2009

Head & Neck Oncology 1/2009 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine