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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 1/2010

Open Access 01-12-2010 | Research

Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African women

Authors: Livio Azzoni, Nigel J Crowther, Cynthia Firnhaber, Andrea S Foulkes, Xiangfan Yin, Deborah Glencross, Robert Gross, Mitch D Kaplan, Emmanouil Papasavvas, Doreen Schulze, Wendy Stevens, Tessa van der Merwe, Rita Waisberg, Ian Sanne, Luis J Montaner

Published in: Journal of the International AIDS Society | Issue 1/2010

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Abstract

Background

Advanced HIV infection can result in lipoatrophy and wasting, even in the absence of ongoing opportunistic infections, suggesting that HIV may directly affect adipose tissue amount and distribution.

Methods

We assessed the relationship of fat (measured using anthropometry, DEXA, MRI scans) or markers related to glucose and lipid metabolism with viral load in a cross-sectional sample of 83 antiretroviral-naïve HIV-1-infected South African women. A multivariable linear model was fitted to log10VL to assess the combined effect of these variables.

Results

In addition to higher T cell activation, women with viral load greater than the population median had lower waist circumference, body mass index and subcutaneous abdominal fat, as well as lower serum leptin. We demonstrate that leptin serum levels are inversely associated with viral replication, independent of the amount of adipose tissue. This association is maintained after adjusting for multiple variables associated with disease progression (i.e., cellular activation and innate immunity effector levels).

Conclusions

Our results demonstrate that serum leptin levels are inversely associated with viral replication, independent of disease progression: we postulate that leptin may affect viral replication.
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Metadata
Title
Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African women
Authors
Livio Azzoni
Nigel J Crowther
Cynthia Firnhaber
Andrea S Foulkes
Xiangfan Yin
Deborah Glencross
Robert Gross
Mitch D Kaplan
Emmanouil Papasavvas
Doreen Schulze
Wendy Stevens
Tessa van der Merwe
Rita Waisberg
Ian Sanne
Luis J Montaner
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of the International AIDS Society / Issue 1/2010
Electronic ISSN: 1758-2652
DOI
https://doi.org/10.1186/1758-2652-13-33

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