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Published in: Journal of Experimental & Clinical Cancer Research 1/2012

Open Access 01-12-2012 | Review

Therapeutic strategies in epithelial ovarian cancer

Authors: Ayako Kim, Yutaka Ueda, Tetsuji Naka, Takayuki Enomoto

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2012

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Abstract

Ovarian cancer is the most lethal gynecologic malignancy. It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbria, the most distal part of the fallopian tube.
Treatment of epithelial ovarian cancer is based on the combination of cytoreductive surgery and combination chemotherapy using taxane and platinum. Although clear cell type is categorized in indolent type, it is known to show relatively strong resistance to carboplatin and paclitaxel regimen and thus poor prognosis compared to serous adenocarcinoma, especially in advanced stages. Irinotecan plus cisplatin therapy may effective for the clear cell adenocarcinoma.
The larger expectation for improved prognosis in ovarian carcinoma is related to the use of the new biological agents. One of the most investigated and promising molecular targeted drugs in ovarian cancer is bevacizumab, a monoclonal antibody directed against VEGF. PARP inhibitor is another one. A few recent studies demonstrated positive results of bevacizumab on progression-free survival in ovarian cancer patients, however, investigation of molecular targeting drugs in patients with ovarian cancer are still underway.
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Metadata
Title
Therapeutic strategies in epithelial ovarian cancer
Authors
Ayako Kim
Yutaka Ueda
Tetsuji Naka
Takayuki Enomoto
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2012
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/1756-9966-31-14

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