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Open Access 01-12-2012 | Review

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

Authors: Véronique Gelsi-Boyer, Mandy Brecqueville, Raynier Devillier, Anne Murati, Marie-Joelle Mozziconacci, Daniel Birnbaum

Published in: Journal of Hematology & Oncology | Issue 1/2012

Abstract

The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment.

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Title: Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
Authors: Véronique Gelsi-Boyer
Mandy Brecqueville
Raynier Devillier
Anne Murati
Marie-Joelle Mozziconacci
Daniel Birnbaum
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2012
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/1756-8722-5-12

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