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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2009

Open Access 01-12-2009 | Review

ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside

Authors: Jianbiao Zhou, Boon-Cher Goh, Daniel H Albert, Chien-Shing Chen

Published in: Journal of Hematology & Oncology | Issue 1/2009

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Abstract

Tyrosine Kinase Inhibitors (TKI) have significantly changed the landscape of current cancer therapy. Understanding of mechanisms of aberrant TK signaling and strategies to inhibit TKs in cancer, further promote the development of novel agents.
ABT-869, a novel ATP-competitive receptor tyrosine kinase inhibitor is a potent inhibitor of members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families. ABT-869 showed potent antiproliferative and apoptotic properties in vitro and in animal cancer xenograft models using tumor cell lines that were "addicted" to signaling of kinases targeted by ABT-869. When given together with chemotherapy or mTOR inhibitors, ABT-869 showed at least additive therapeutic effects. The phase I trial for ABT-869 was recently completed and it demonstrated respectable efficacy in solid tumors including lung and hepatocellular carcinoma with manageable side effects. Tumor cavitation and reduction of contrast enhancement after ABT-869 treatment supported the antiangiogenic activity. The correlative laboratory studies conducted with the trial also highlight potential biomarkers for future patient selection and treatment outcome.
Parallel to the clinical development, in vitro studies on ABT-869 resistance phenotype identified novel resistance mechanism that may be applicable to other TKIs. The future therapeutic roles of ABT-869 are currently been tested in phase II trials.
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Literature
1.
Blume-Jensen P, Hunter T: Oncogenic kinase signalling. Nature. 2001, 411: 355-65. 10.1038/35077225.CrossRefPubMed
2.
den Hertog J, Ostman A, Bohmer FD: Protein tyrosine phosphatases: regulatory mechanisms. Febs J. 2008, 275: 831-47. 10.1111/j.1742-4658.2008.06247.x.CrossRefPubMed
3.
Rosnet O, Birnbaum D: Hematopoietic receptors of class III receptor-type tyrosine kinases. Crit Rev Oncog. 1993, 4: 595-613.PubMed
4.
Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM: STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA. 1994, 91: 459-63. 10.1073/pnas.91.2.459.PubMedCentralCrossRefPubMed
5.
Lyman SD, James L, Johnson L, Brasel K, de Vries P, Escobar SS, Downey H, Splett RR, Beckmann MP, McKenna HJ: Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. Blood. 1994, 83: 2795-801.PubMed
6.
Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, Sonoda Y, Fujimoto T, Misawa S: Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996, 10: 1911-8.PubMed
7.
Gilliland DG, Griffin JD: The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002, 100: 1532-42. 10.1182/blood-2002-02-0492.CrossRefPubMed
8.
Stirewalt DL, Radich JP: The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003, 3: 650-65. 10.1038/nrc1169.CrossRefPubMed
9.
Levis M, Small D: FLT3: IT Does matter in leukemia. Leukemia. 2003, 17: 1738-52. 10.1038/sj.leu.2403099.CrossRefPubMed
10.
Sternberg DW, Licht JD: Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges. Curr Opin Hematol. 2005, 12: 7-13. 10.1097/01.moh.0000147891.06584.d7.CrossRefPubMed
11.
Ferrara N, Gerber HP, LeCouter J: The biology of VEGF and its receptors. Nat Med. 2003, 9: 669-76. 10.1038/nm0603-669.CrossRefPubMed
12.
Bergers G, Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003, 3: 401-10. 10.1038/nrc1093.CrossRefPubMed
13.
Zhou J, Mauerer K, Farina L, Gribben JG: The role of the tumor microenvironment in hematological malignancies and implication for therapy. Front Biosci. 2005, 10: 1581-96. 10.2741/1642.CrossRefPubMed
14.
Dias S, Hattori K, Zhu Z, Heissig B, Choy M, Lane W, Wu Y, Chadburn A, Hyjek E, Gill M, Hicklin DJ, Witte L, Moore MA, Rafii S: Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J Clin Invest. 2000, 106: 511-21. 10.1172/JCI8978.PubMedCentralCrossRefPubMed
15.
Fiedler W, Graeven U, Ergun S, Verago S, Kilic N, Stockschlader M, Hossfeld DK: Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood. 1997, 89: 1870-5.PubMed
16.
List AF, Glinsmann-Gibson B, Stadheim C, Meuillet EJ, Bellamy W, Powis G: Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells. Exp Hematol. 2004, 32: 526-35. 10.1016/j.exphem.2004.03.005.CrossRefPubMed
17.
Santos SC, Dias S: Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways. Blood. 2004, 103: 3883-9. 10.1182/blood-2003-05-1634.CrossRefPubMed
18.
Albert DH, Tapang P, Magoc TJ, Pease LJ, Reuter DR, Wei RQ, Li J, Guo J, Bousquet PF, Ghoreishi-Haack NS, Wang B, Bukofzer GT, Wang YC, Stavropoulos JA, Hartandi K, Niquette AL, Soni N, Johnson EF, McCall JO, Bouska JJ, Luo Y, Donawho CK, Dai Y, Marcotte PA, Glaser KB, Michaelides MR, Davidsen SK: Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther. 2006, 5: 995-1006. 10.1158/1535-7163.MCT-05-0410.CrossRefPubMed
19.
Dai Y, Hartandi K, Ji Z, Ahmed AA, Albert DH, Bauch JL, Bouska JJ, Bousquet PF, Cunha GA, Glaser KB, Harris CM, Hickman D, Guo J, Li J, Marcotte PA, Marsh KC, Moskey MD, Martin RL, Olson AM, Osterling DJ, Pease LJ, Soni NB, Stewart KD, Stoll VS, Tapang P, Reuter DR, Davidsen SK, Michaelides MR: Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor. J Med Chem. 2007, 50: 1584-97. 10.1021/jm061280h.CrossRefPubMed
20.
Guo J, Marcotte PA, McCall JO, Dai Y, Pease LJ, Michaelides MR, Davidsen SK, Glaser KB: Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. Mol Cancer Ther. 2006, 5: 1007-13. 10.1158/1535-7163.MCT-05-0359.CrossRefPubMed
21.
Li TWJP: Cellular activity of ABT-869 against colony-stimulating-factor-1 receptor (CSF-1R) in macrophage-like cell lines [abstract]. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research. 2009, Denver, CO: Philadelphia (PA): AACR, Abstract nr 1789
22.
Zhou J, Pan M, Xie Z, Loh SL, Bi C, Tai YC, Lilly M, Lim YP, Han JH, Glaser KB, Albert DH, Davidsen SK, Chen CS: Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway. Leukemia. 2008, 22: 138-46. 10.1038/sj.leu.2404960.CrossRefPubMed
23.
Donawho C HJ, Wang YC, Bukofzer G, Dai Y, Davidsen S, Wang B, Schlessinger S, Frost D: The RTK inhibitor ABT-869, alone and in combination with paclitaxel and/or zoledronic acid, demonstrates significant reduction in the development of both osteoblastic (LuCap 23.1) and osteolytic (PC3-M-Luciferase) tumors intratibially. AACR Meeting Abstracts 2007. 2007, C204-
24.
Jasinghe VJ, Xie Z, Zhou J, Khng J, Poon LF, Senthilnathan P, Glaser KB, Albert DH, Davidsen SK, Chen CS: ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft. J Hepatol. 2008, 49: 985-97. 10.1016/j.jhep.2008.08.010.CrossRefPubMed
25.
Li L, Lin X, Shoemaker AR, Albert DH, Fesik SW, Shen Y: Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo. Clin Cancer Res. 2006, 12: 4747-54. 10.1158/1078-0432.CCR-05-2842.CrossRefPubMed
26.
Kim KT, Baird K, Ahn JY, Meltzer P, Lilly M, Levis M, Small D: Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival. Blood. 2005, 105: 1759-67. 10.1182/blood-2004-05-2006.CrossRefPubMed
27.
Shankar DB, Li J, Tapang P, Owen McCall J, Pease LJ, Dai Y, Wei RQ, Albert DH, Bouska JJ, Osterling DJ, Guo J, Marcotte PA, Johnson EF, Soni N, Hartandi K, Michaelides MR, Davidsen SK, Priceman SJ, Chang JC, Rhodes K, Shah N, Moore TB, Sakamoto KM, Glaser KB: ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia. Blood. 2007, 109: 3400-8. 10.1182/blood-2006-06-029579.PubMedCentralCrossRefPubMed
28.
Brown P, Levis M, McIntyre E, Griesemer M, Small D: Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner. Leukemia. 2006, 20: 1368-76. 10.1038/sj.leu.2404277.CrossRefPubMed
29.
Fiedler W, Mesters R, Tinnefeld H, Loges S, Staib P, Duhrsen U, Flasshove M, Ottmann OG, Jung W, Cavalli F, Kuse R, Thomalla J, Serve H, O'Farrell AM, Jacobs M, Brega NM, Scigalla P, Hossfeld DK, Berdel WE: A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood. 2003, 102: 2763-7. 10.1182/blood-2002-10-2998.CrossRefPubMed
30.
O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A, Smolich BD, Manning WC, Murray LJ, Heinrich MC, Cherrington JM: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003, 101: 3597-605. 10.1182/blood-2002-07-2307.CrossRefPubMed
31.
Roboz GJ, Giles FJ, List AF, Cortes JE, Carlin R, Kowalski M, Bilic S, Masson E, Rosamilia M, Schuster MW, Laurent D, Feldman EJ: Phase 1 study of PTK787/ZK 22 a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome. Leukemia. 2584, 20: 952-7. 10.1038/sj.leu.2404213.CrossRef
32.
Zhou J, Khng J, Jasinghe VJ, Bi C, Neo CH, Pan M, Poon LF, Xie Z, Yu H, Yeoh AE, Lu Y, Glaser KB, Albert DH, Davidsen SK, Chen CS: In vivo activity of ABT-869, a multi-target kinase inhibitor, against acute myeloid leukemia with wild-type FLT3 receptor. Leuk Res. 2008, 32: 1091-100. 10.1016/j.leukres.2007.11.025.CrossRefPubMed
33.
Semenza GL: Angiogenesis in ischemic and neoplastic disorders. Annu Rev Med. 2003, 54: 17-28. 10.1146/annurev.med.54.101601.152418.CrossRefPubMed
34.
Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M, Kojiro M: Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology. 1998, 28: 68-77. 10.1002/hep.510280111.CrossRefPubMed
35.
Baldo P, Cecco S, Giacomin E, Lazzarini R, Ros B, Marastoni S: mTOR pathway and mTOR inhibitors as agents for cancer therapy. Curr Cancer Drug Targets. 2008, 8: 647-65. 10.2174/156800908786733513.CrossRefPubMed
36.
Schmelzle T, Hall MN: TOR, a central controller of cell growth. Cell. 2000, 103: 253-62. 10.1016/S0092-8674(00)00117-3.CrossRefPubMed
37.
Yap TA, Garrett MD, Walton MI, Raynaud F, de Bono JS, Workman P: Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol. 2008, 8: 393-412. 10.1016/j.coph.2008.08.004.CrossRefPubMed
38.
39.
Tanaka S, Arii S: Molecularly targeted therapy for hepatocellular carcinoma. Cancer Sci. 2009, 100: 1-8. 10.1111/j.1349-7006.2008.01006.x.CrossRefPubMed
40.
Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK: Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med. 2002, 8: 128-35. 10.1038/nm0202-128.CrossRefPubMed
41.
Sahin F, Kannangai R, Adegbola O, Wang J, Su G, Torbenson M: mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res. 2004, 10: 8421-5. 10.1158/1078-0432.CCR-04-0941.CrossRefPubMed
42.
DeAngelo DJ, Stone RM, Heaney ML, Nimer SD, Paquette RL, Klisovic RB, Caligiuri MA, Cooper MR, Lecerf JM, Karol MD, Sheng S, Holford N, Curtin PT, Druker BJ, Heinrich MC: Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics. Blood. 2006, 108: 3674-81. 10.1182/blood-2006-02-005702.PubMedCentralCrossRefPubMed
43.
Fiedler W, Serve H, Dohner H, Schwittay M, Ottmann OG, O'Farrell AM, Bello CL, Allred R, Manning WC, Cherrington JM, Louie SG, Hong W, Brega NM, Massimini G, Scigalla P, Berdel WE, Hossfeld DK: A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood. 2005, 105: 986-93. 10.1182/blood-2004-05-1846.CrossRefPubMed
44.
Knapper S, Burnett AK, Littlewood T, Kell WJ, Agrawal S, Chopra R, Clark R, Levis MJ, Small D: A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood. 2006, 108: 3262-70. 10.1182/blood-2006-04-015560.CrossRefPubMed
45.
Small D: FLT3 mutations: biology and treatment. Hematology Am Soc Hematol Educ Program. 2006, 178-84.
46.
Druker BJ, Sawyers CL, Capdeville R, Ford JM, Baccarani M, Goldman JM: Chronic myelogenous leukemia. Hematology (Am Soc Hematol Educ Program). 2001, 87-112.
47.
Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, Sawyers CL: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001, 293: 876-80. 10.1126/science.1062538.CrossRefPubMed
48.
Heidel F MF, Breitenbucher F, Dove S, Huber C, Bohmer FD, Ficher T: Bis(1H-indol-2-yl)methanones are effective inhibitors of mutated FLT3 tyrosine kinase, overcome resistance to PKC421A in vitro and show synergy with chemotherapy. Blood. 2006, 108:
49.
Piloto O, Wright M, Brown P, Kim KT, Levis M, Small D: Frolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways. Blood. 2007, 109: 1643-52. 10.1182/blood-2006-05-023804.PubMedCentralCrossRefPubMed
50.
Zhou J, Bi C, Janakakumara JV, Liu SC, Chng WJ, Tay KG, Poon LF, Xie Z, Palaniyandi S, Yu H, Glaser KB, Albert DH, Davidsen SK, Chen CS: Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML. Blood. 2009, 113: 4052-62. 10.1182/blood-2008-05-156422.CrossRefPubMed
51.
Wormald S, Hilton DJ: The negative regulatory roles of suppressor of cytokine signaling proteins in myeloid signaling pathways. Curr Opin Hematol. 2007, 14: 9-15. 10.1097/00062752-200701000-00004.CrossRefPubMed
52.
53.
Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J: Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature. 1994, 368: 643-8. 10.1038/368643a0.CrossRefPubMed
54.
Rusten LS, Lyman SD, Veiby OP, Jacobsen SE: The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro. Blood. 1996, 87: 1317-25.PubMed
55.
Dehmel U, Zaborski M, Meierhoff G, Rosnet O, Birnbaum D, Ludwig WD, Quentmeier H, Drexler HG: Effects of FLT3 ligand on human leukemia cells. I. Proliferative response of myeloid leukemia cells. Leukemia. 1996, 10: 261-70.PubMed
56.
Zheng R, Levis M, Piloto O, Brown P, Baldwin BR, Gorin NC, Beran M, Zhu Z, Ludwig D, Hicklin D, Witte L, Li Y, Small D: FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood. 2004, 103: 267-74. 10.1182/blood-2003-06-1969.CrossRefPubMed
57.
Scheijen B, Ngo HT, Kang H, Griffin JD: FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins. Oncogene. 2004, 23: 3338-49. 10.1038/sj.onc.1207456.CrossRefPubMed
58.
Ambrosini G, Adida C, Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997, 3: 917-21. 10.1038/nm0897-917.CrossRefPubMed
59.
Zaffaroni N, Pennati M, Daidone MG: Survivin as a target for new anticancer interventions. J Cell Mol Med. 2005, 9: 360-72. 10.1111/j.1582-4934.2005.tb00361.x.CrossRefPubMed
60.
Fukuda S, Pelus LM: Survivin, a cancer target with an emerging role in normal adult tissues. Mol Cancer Ther. 2006, 5: 1087-98. 10.1158/1535-7163.MCT-05-0375.CrossRefPubMed
61.
Altieri DC: Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer. 2008, 8: 61-70. 10.1038/nrc2293.CrossRefPubMed
62.
Altieri DC: Validating survivin as a cancer therapeutic target. Nat Rev Cancer. 2003, 3: 46-54. 10.1038/nrc968.CrossRefPubMed
63.
Nam S, Buettner R, Turkson J, Kim D, Cheng JQ, Muehlbeyer S, Hippe F, Vatter S, Merz KH, Eisenbrand G, Jove R: Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proc Natl Acad Sci USA. 2005, 102: 5998-6003. 10.1073/pnas.0409467102.PubMedCentralCrossRefPubMed
64.
Wong CI, Koo TS, Soo R, Hartono S, Thng CH, McKeegan E, Yong WP, Chen CS, Lee SC, Wong J, Lim R, Sukri N, Lim SE, Ong AB, Steinberg J, Gupta N, Pradhan R, Humerickhouse R, Goh BC: Phase I and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies. Journal of Clinical Oncology. 2009,
65.
66.
67.
68.
Metadata
Title
ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside
Authors
Jianbiao Zhou
Boon-Cher Goh
Daniel H Albert
Chien-Shing Chen
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2009
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-2-33

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