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Molecular Brain
Published in: Molecular Brain 1/2013

Open Access 01-12-2013 | Research

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

Authors: Kyongman An, Igor Klyubin, Youngkyu Kim, Jung Hoon Jung, Alexandra J Mably, Sean T O’Dowd, Timothy Lynch, Daniel Kanmert, Cynthia A Lemere, Gina M Finan, Joon Won Park, Tae-Wan Kim, Dominic M Walsh, Michael J Rowan, Joung-Hun Kim

Published in: Molecular Brain | Issue 1/2013

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Abstract

Background

Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer’s disease (AD)-associated amyloid β-protein (Aβ). Despite their ubiquitous presence and the inclusion of components which can potentially interact with Aβ, the role of exosomes in regulating synaptic dysfunction induced by Aβ has not been explored.

Results

We here provide in vivo evidence that exosomes derived from N2a cells or human cerebrospinal fluid can abrogate the synaptic-plasticity-disrupting activity of both synthetic and AD brain-derived Aβ. Mechanistically, this effect involves sequestration of synaptotoxic Aβ assemblies by exosomal surface proteins such as PrPC rather than Aβ proteolysis.

Conclusions

These data suggest that exosomes can counteract the inhibitory action of Aβ, which contributes to perpetual capability for synaptic plasticity.
Appendix
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Metadata
Title
Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo
Authors
Kyongman An
Igor Klyubin
Youngkyu Kim
Jung Hoon Jung
Alexandra J Mably
Sean T O’Dowd
Timothy Lynch
Daniel Kanmert
Cynthia A Lemere
Gina M Finan
Joon Won Park
Tae-Wan Kim
Dominic M Walsh
Michael J Rowan
Joung-Hun Kim
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Molecular Brain / Issue 1/2013
Electronic ISSN: 1756-6606
DOI
https://doi.org/10.1186/1756-6606-6-47

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