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Molecular Brain
Published in: Molecular Brain 1/2011

Open Access 01-12-2011 | Review

APP processing in Alzheimer's disease

Authors: Yun-wu Zhang, Robert Thompson, Han Zhang, Huaxi Xu

Published in: Molecular Brain | Issue 1/2011

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Abstract

An important pathological feature of Alzheimer's disease (AD) is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides called β-amyloid (Aβ). Multiple lines of evidence demonstrate that overproduction/aggregation of Aβ in the brain is a primary cause of AD and inhibition of Aβ generation has become a hot topic in AD research. Aβ is generated from β-amyloid precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase complex. Alternatively, APP can be cleaved by α-secretase within the Aβ domain to release soluble APPα and preclude Aβ generation. Cleavage of APP by caspases may also contribute to AD pathologies. Therefore, understanding the metabolism/processing of APP is crucial for AD therapeutics. Here we review current knowledge of APP processing regulation as well as the patho/physiological functions of APP and its metabolites.
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Metadata
Title
APP processing in Alzheimer's disease
Authors
Yun-wu Zhang
Robert Thompson
Han Zhang
Huaxi Xu
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Molecular Brain / Issue 1/2011
Electronic ISSN: 1756-6606
DOI
https://doi.org/10.1186/1756-6606-4-3

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