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Molecular Brain
Published in: Molecular Brain 1/2011

Open Access 01-12-2011 | Research

Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior

Authors: Keri Martinowich, Robert J Schloesser, Dennisse V Jimenez, Daniel R Weinberger, Bai Lu

Published in: Molecular Brain | Issue 1/2011

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Abstract

Background

Sleep homeostasis is characterized by a positive correlation between sleep length and intensity with the duration of the prior waking period. A causal role for brain-derived neurotrophic factor (BDNF) in sleep homeostasis has been suggested, but the underlying mechanisms remain unclear. Cortistatin, a neuropeptide expressed primarily in a subset of cortical GABAergic interneurons, is another molecule implicated in sleep homeostasis.

Results

We confirmed that sleep deprivation leads to an increase in cortical cortistatin mRNA expression. Disruption of activity-dependent BDNF expression in a genetically modified mouse line impairs both baseline levels of cortistatin mRNA as well as its levels following sleep deprivation. Disruption of activity-dependent BDNF also leads to a decrease in sleep time during the active (dark) phase.

Conclusion

Our studies suggest that regulation of cortistatin-expressing interneurons by activity-dependent BDNF expression may contribute to regulation of sleep behavior.
Appendix
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Metadata
Title
Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior
Authors
Keri Martinowich
Robert J Schloesser
Dennisse V Jimenez
Daniel R Weinberger
Bai Lu
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Molecular Brain / Issue 1/2011
Electronic ISSN: 1756-6606
DOI
https://doi.org/10.1186/1756-6606-4-11

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