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Open Access 01-12-2013 | Review

Neutrophil roles in left ventricular remodeling following myocardial infarction

Authors: Yonggang Ma, Andriy Yabluchanskiy, Merry L Lindsey

Published in: Fibrogenesis & Tissue Repair | Issue 1/2013

Abstract

Polymorphonuclear granulocytes (PMNs; neutrophils) serve as key effector cells in the innate immune system and provide the first line of defense against invading microorganisms. In addition to producing inflammatory cytokines and chemokines and undergoing a respiratory burst that stimulates the release of reactive oxygen species, PMNs also degranulate to release components that kill pathogens. Recently, neutrophil extracellular traps have been shown to be an alternative way to trap microorganisms and contain infection. PMN-derived granule components are also involved in multiple non-infectious inflammatory processes, including the response to myocardial infarction (MI). In this review, we will discuss the biological characteristics, recruitment, activation, and removal of PMNs, as well as the roles of PMN-derived granule proteins in inflammation and innate immunity, focusing on the MI setting when applicable. We also discuss future perspectives that will direct research in PMN biology.

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Title: Neutrophil roles in left ventricular remodeling following myocardial infarction
Authors: Yonggang Ma
Andriy Yabluchanskiy
Merry L Lindsey
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Fibrogenesis & Tissue Repair / Issue 1/2013
Electronic ISSN: 1755-1536
DOI: https://doi.org/10.1186/1755-1536-6-11

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