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Published in: Conflict and Health 1/2010

Open Access 01-12-2010 | Research

Provision of antiretroviral treatment in conflict settings: the experience of Médecins Sans Frontières

Authors: Daniel P O'Brien, Sarah Venis, Jane Greig, Leslie Shanks, Tom Ellman, Kalpana Sabapathy, Lisa Frigati, Clair Mills

Published in: Conflict and Health | Issue 1/2010

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Abstract

Introduction

Many countries ravaged by conflict have substantial morbidity and mortality attributed to HIV/AIDS yet HIV treatment is uncommonly available. Universal access to HIV care cannot be achieved unless the needs of populations in conflict-affected areas are addressed.

Methods

From 2003 Médecins Sans Frontières introduced HIV care, including antiretroviral therapy, into 24 programmes in conflict or post-conflict settings, mainly in sub-Saharan Africa. HIV care and treatment activities were usually integrated within other medical activities. Project data collected in the Fuchia software system were analysed and outcomes compared with ART-LINC data. Programme reports and other relevant documents and interviews with local and headquarters staff were used to develop lessons learned.

Results

In the 22 programmes where ART was initiated, more than 10,500 people were diagnosed with HIV and received medical care, and 4555 commenced antiretroviral therapy, including 348 children. Complete data were available for adults in 20 programmes (n = 4145). At analysis, 2645 (64%) remained on ART, 422 (10%) had died, 466 (11%) lost to follow-up, 417 (10%) transferred to another programme, and 195 (5%) had an unclear outcome. Median 12-month mortality and loss to follow-up were 9% and 11% respectively, and median 6-month CD4 gain was 129 cells/mm 3.
Patient outcomes on treatment were comparable to those in stable resource-limited settings, and individuals and communities obtained significant benefits from access to HIV treatment. Programme disruption through instability was uncommon with only one program experiencing interruption to services, and programs were adapted to allow for disruption and population movements. Integration of HIV activities strengthened other health activities contributing to health benefits for all victims of conflict and increasing the potential sustainability for implemented activities.

Conclusions

With commitment, simplified treatment and monitoring, and adaptations for potential instability, HIV treatment can be feasibly and effectively provided in conflict or post-conflict settings.
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Literature
1.
go back to reference Spiegel PB, Bennedsen AR, Claass J, Bruns L, Patterson N, Yiweza D: Prevalence of HIV infection in conflict-affected and displaced people in seven sub-Saharan African countries: a systematic review. Lancet. 2007, 369 (9580): 2187-95. 10.1016/S0140-6736(07)61015-0.CrossRefPubMed Spiegel PB, Bennedsen AR, Claass J, Bruns L, Patterson N, Yiweza D: Prevalence of HIV infection in conflict-affected and displaced people in seven sub-Saharan African countries: a systematic review. Lancet. 2007, 369 (9580): 2187-95. 10.1016/S0140-6736(07)61015-0.CrossRefPubMed
2.
go back to reference HIV and Conflict: A Double Emergency. Save the Children. 2002, London HIV and Conflict: A Double Emergency. Save the Children. 2002, London
4.
go back to reference Chamla DD, Olu O, Wanyana J, Natseri N, Mukooyo E, Okware S: Geographical information system and access to HIV testing, treatment and prevention of mother-to-child transmission in conflict affected Northern Uganda. Confl Health. 2007, 1: 12-10.1186/1752-1505-1-12.PubMedCentralCrossRefPubMed Chamla DD, Olu O, Wanyana J, Natseri N, Mukooyo E, Okware S: Geographical information system and access to HIV testing, treatment and prevention of mother-to-child transmission in conflict affected Northern Uganda. Confl Health. 2007, 1: 12-10.1186/1752-1505-1-12.PubMedCentralCrossRefPubMed
5.
go back to reference Shannon K, Kaida A, Rachlis B, Lloyd-Smith E, Gray G, Strathdee SA: Reconsidering the impact of conflict on HIV infection among women in the era of antiretroviral treatment scale-up in sub-Saharan Africa: a gender lens. AIDS. 2008, 22: 1705-1707. 10.1097/QAD.0b013e328308de0e.CrossRefPubMed Shannon K, Kaida A, Rachlis B, Lloyd-Smith E, Gray G, Strathdee SA: Reconsidering the impact of conflict on HIV infection among women in the era of antiretroviral treatment scale-up in sub-Saharan Africa: a gender lens. AIDS. 2008, 22: 1705-1707. 10.1097/QAD.0b013e328308de0e.CrossRefPubMed
6.
go back to reference Mermin J, Were W, Ekwaru JP, Moore D, Downing R, Behumbiize P: Mortality in HIV-infected Ugandan adults receiving antiretroviral treatment and survival of their HIV-uninfected children: a prospective cohort study. Lancet. 2008, 371 (9614): 752-9. 10.1016/S0140-6736(08)60345-1.CrossRefPubMed Mermin J, Were W, Ekwaru JP, Moore D, Downing R, Behumbiize P: Mortality in HIV-infected Ugandan adults receiving antiretroviral treatment and survival of their HIV-uninfected children: a prospective cohort study. Lancet. 2008, 371 (9614): 752-9. 10.1016/S0140-6736(08)60345-1.CrossRefPubMed
7.
go back to reference De Cock KM, Crowley SP, Lo YR, Granich RM, Williams BG: Preventing HIV transmission with antiretrovirals. Bulletin of the World Health Organization. 2009, 87: 488-488. 10.2471/BLT.09.067330.PubMedCentralCrossRefPubMed De Cock KM, Crowley SP, Lo YR, Granich RM, Williams BG: Preventing HIV transmission with antiretrovirals. Bulletin of the World Health Organization. 2009, 87: 488-488. 10.2471/BLT.09.067330.PubMedCentralCrossRefPubMed
8.
go back to reference Ellman T, Culbert H, Torres-Feced V: Treatment of AIDS in conflict-affected settings: a failure of imagination. Lancet. 2005, 365 (9456): 278-80.CrossRefPubMed Ellman T, Culbert H, Torres-Feced V: Treatment of AIDS in conflict-affected settings: a failure of imagination. Lancet. 2005, 365 (9456): 278-80.CrossRefPubMed
10.
go back to reference Inter-Agency Standing Committee (IASC): Guidelines for HIV/AIDS interventions in emergency settings. Geneva. 2004 Inter-Agency Standing Committee (IASC): Guidelines for HIV/AIDS interventions in emergency settings. Geneva. 2004
11.
go back to reference Culbert H, Tu D, O'Brien DP, Ellman T, Mills C, Ford N: HIV treatment in a conflict setting: Outcomes and experiences from Bukav, Democratic Republic of the Congo. PLoS Med. 2007, 4 (5): e129-10.1371/journal.pmed.0040129.PubMedCentralCrossRefPubMed Culbert H, Tu D, O'Brien DP, Ellman T, Mills C, Ford N: HIV treatment in a conflict setting: Outcomes and experiences from Bukav, Democratic Republic of the Congo. PLoS Med. 2007, 4 (5): e129-10.1371/journal.pmed.0040129.PubMedCentralCrossRefPubMed
12.
go back to reference O'Brien DP, Mills C, Hamel C, Ford N, Pottie K: Universal access: the benefits and challenges in bringing integrated HIV care to isolated and conflict affected populations in the Republic of Congo. Conflict and Health. 2009, 3: 1-10.1186/1752-1505-3-1.PubMedCentralCrossRefPubMed O'Brien DP, Mills C, Hamel C, Ford N, Pottie K: Universal access: the benefits and challenges in bringing integrated HIV care to isolated and conflict affected populations in the Republic of Congo. Conflict and Health. 2009, 3: 1-10.1186/1752-1505-3-1.PubMedCentralCrossRefPubMed
13.
go back to reference Kiboneka A, Wangisi J, Nabiryo C, Tembe J, Kusemererwa S, Olupot-Olupot P: Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda. AIDS. 2008, 22 (18): 2493-9. 10.1097/QAD.0b013e328318f148.CrossRefPubMed Kiboneka A, Wangisi J, Nabiryo C, Tembe J, Kusemererwa S, Olupot-Olupot P: Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda. AIDS. 2008, 22 (18): 2493-9. 10.1097/QAD.0b013e328318f148.CrossRefPubMed
14.
go back to reference Kiboneka A, Nyatia RJ, Nabiryo C, Anema A, Cooper CL, Fernandes KA: Combination antiretroviral therapy in population affected by conflict: outcomes from large cohort in northern Uganda. BMJ. 2009, 338: b201-10.1136/bmj.b201. doi: 10.1136/bmj.b201PubMedCentralCrossRefPubMed Kiboneka A, Nyatia RJ, Nabiryo C, Anema A, Cooper CL, Fernandes KA: Combination antiretroviral therapy in population affected by conflict: outcomes from large cohort in northern Uganda. BMJ. 2009, 338: b201-10.1136/bmj.b201. doi: 10.1136/bmj.b201PubMedCentralCrossRefPubMed
16.
go back to reference World Health Organisation: Towards universal access: scaling-up priority HIV/AIDS interventions in the health sector: progress report 2008. Geneva. 2008 World Health Organisation: Towards universal access: scaling-up priority HIV/AIDS interventions in the health sector: progress report 2008. Geneva. 2008
17.
go back to reference Consensus statement: WHO UNHCR, UNAIDS MSF and UNICEF 19-20 September. Geneva. 2006 Consensus statement: WHO UNHCR, UNAIDS MSF and UNICEF 19-20 September. Geneva. 2006
20.
go back to reference World Health Organisation: Guidance on provider-initiated HIV testing and counseling in health facilities. 2007, Geneva World Health Organisation: Guidance on provider-initiated HIV testing and counseling in health facilities. 2007, Geneva
21.
go back to reference Klarkowski DB, Wazome JM, Lokuge KM, Shanks L, Mills CF, O'Brien DP: (2009) The Evaluation of a Rapid In Situ HIV Confirmation Test in a Programme with a High Failure Rate of the WHO HIV Two-Test Diagnostic Algorithm. PLoS ONE. 4 (2): e4351-10.1371/journal.pone.0004351. Klarkowski DB, Wazome JM, Lokuge KM, Shanks L, Mills CF, O'Brien DP: (2009) The Evaluation of a Rapid In Situ HIV Confirmation Test in a Programme with a High Failure Rate of the WHO HIV Two-Test Diagnostic Algorithm. PLoS ONE. 4 (2): e4351-10.1371/journal.pone.0004351.
22.
go back to reference World Health Organisation: Antiretroviral therapy for adults and adolescents in resource-limited settings: towards universal access. 2006, Geneva World Health Organisation: Antiretroviral therapy for adults and adolescents in resource-limited settings: towards universal access. 2006, Geneva
23.
go back to reference Hehenkamp A, Hargreaves S: Tuberculosis treatment in complex emergencies: South Sudan. Lancet. 2003, 362: s30-31. 10.1016/S0140-6736(03)15066-0.CrossRefPubMed Hehenkamp A, Hargreaves S: Tuberculosis treatment in complex emergencies: South Sudan. Lancet. 2003, 362: s30-31. 10.1016/S0140-6736(03)15066-0.CrossRefPubMed
24.
go back to reference Reid T, van Engelgem I, Telfer B, Manzi M: Providing HIV care in the aftermath of Kenya's post-election violence Medecins Sans Frontieres' lessons learned January - March 2008. Confl Health. 2008, 2: 15-10.1186/1752-1505-2-15.PubMedCentralCrossRefPubMed Reid T, van Engelgem I, Telfer B, Manzi M: Providing HIV care in the aftermath of Kenya's post-election violence Medecins Sans Frontieres' lessons learned January - March 2008. Confl Health. 2008, 2: 15-10.1186/1752-1505-2-15.PubMedCentralCrossRefPubMed
25.
go back to reference Calmy A, Pinoges L, Szumilin E, Zachariah R, Ford N, Ferradini L: Generic fixed-dose combination antiretroviral treatment in resource-poor settings: multicentric observational cohort. AIDS. 2006, 20 (8): 1163-9. 10.1097/01.aids.0000226957.79847.d6.CrossRefPubMed Calmy A, Pinoges L, Szumilin E, Zachariah R, Ford N, Ferradini L: Generic fixed-dose combination antiretroviral treatment in resource-poor settings: multicentric observational cohort. AIDS. 2006, 20 (8): 1163-9. 10.1097/01.aids.0000226957.79847.d6.CrossRefPubMed
26.
go back to reference Ferradini L, Jeannin A, Pinoges L: Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment. Lancet. 2006, 367: 1335-1342. 10.1016/S0140-6736(06)68580-2.CrossRefPubMed Ferradini L, Jeannin A, Pinoges L: Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment. Lancet. 2006, 367: 1335-1342. 10.1016/S0140-6736(06)68580-2.CrossRefPubMed
27.
go back to reference Elema R, Mills C, Yun O, Ssonko C, Nyirongo N, Mtonga V, Zulu H, Tu D, O'Brien DP: Outcomes of a remote, decentralized health center-based HIV/AIDS antiretroviral program in Zambia, 2004-2007. J Int Assoc Physicians AIDS Care. 2009, 8 (1): 60-67. 10.1177/1545109709331472.CrossRef Elema R, Mills C, Yun O, Ssonko C, Nyirongo N, Mtonga V, Zulu H, Tu D, O'Brien DP: Outcomes of a remote, decentralized health center-based HIV/AIDS antiretroviral program in Zambia, 2004-2007. J Int Assoc Physicians AIDS Care. 2009, 8 (1): 60-67. 10.1177/1545109709331472.CrossRef
28.
go back to reference Boulle A, Van Gustum G, Hilderbrand K, Cragg C, Abrahams M, Mathee S, Ford N, Knight L, Osler M, Myers J, Goemaere E, Coetzee D, Maartens G: Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa. AIDS. 2010, 24: 563-572. 10.1097/QAD.0b013e328333bfb7.CrossRefPubMed Boulle A, Van Gustum G, Hilderbrand K, Cragg C, Abrahams M, Mathee S, Ford N, Knight L, Osler M, Myers J, Goemaere E, Coetzee D, Maartens G: Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa. AIDS. 2010, 24: 563-572. 10.1097/QAD.0b013e328333bfb7.CrossRefPubMed
29.
go back to reference Antiretroviral Therapy in Lower Income Countries (ART-LINC) Collaboration and ART Cohort Collaboration (ART-CC) groups: Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet. 2006, 367: 817-824. 10.1016/S0140-6736(06)68337-2.CrossRef Antiretroviral Therapy in Lower Income Countries (ART-LINC) Collaboration and ART Cohort Collaboration (ART-CC) groups: Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet. 2006, 367: 817-824. 10.1016/S0140-6736(06)68337-2.CrossRef
30.
go back to reference Zachariah R, Van Engelgem I, Massaquoi M, Kocholla L, Manzi M, Suleh A: Payment for antiretroviral drugs is associated with a higher rate of patients lost to follow-up than those offered free-of-charge therapy in Nairobi, Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene (2008). 102: 288-293. Zachariah R, Van Engelgem I, Massaquoi M, Kocholla L, Manzi M, Suleh A: Payment for antiretroviral drugs is associated with a higher rate of patients lost to follow-up than those offered free-of-charge therapy in Nairobi, Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene (2008). 102: 288-293.
31.
go back to reference Vreeman RC, Nyandiko WM, Sang E, Musick BS, Braitstein P, Wiehe SE: Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya Confl Health. 2009, 3: 5. Vreeman RC, Nyandiko WM, Sang E, Musick BS, Braitstein P, Wiehe SE: Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya Confl Health. 2009, 3: 5.
32.
go back to reference El-Khatib Z, Richter M: Free State? The moratorium's threat to patients' adherence and the development of drug-resistant HIV. S Afr Med J. 2009, 412-414. El-Khatib Z, Richter M: Free State? The moratorium's threat to patients' adherence and the development of drug-resistant HIV. S Afr Med J. 2009, 412-414.
33.
go back to reference Balkan S, O'Brien D, Humblet P, Pujades M, MSF AIDS Working Group: The Burden of OI in Adults Receiving ART in Resource-limited Settings in Médecins Sans Frontières-supported Projects 14th Conference of Retroviruses and Opportunistic Infections, Los Angeles. 2007, Abstract # 839 Balkan S, O'Brien D, Humblet P, Pujades M, MSF AIDS Working Group: The Burden of OI in Adults Receiving ART in Resource-limited Settings in Médecins Sans Frontières-supported Projects 14th Conference of Retroviruses and Opportunistic Infections, Los Angeles. 2007, Abstract # 839
34.
go back to reference Chaix ML, Ekouevi DK, Rouet F, Tonwe-Gold B, Viho I: (2006) Low risk of nevirapine resistance mutations in the prevention of mother-to-child transmission of HIV-1: Agence Nationale de Recherches sur le SIDA Ditrame Plus,.Abidjan, Cote d'Ivoire. J Infect Dis. 193: 482-487. 10.1086/499966. Chaix ML, Ekouevi DK, Rouet F, Tonwe-Gold B, Viho I: (2006) Low risk of nevirapine resistance mutations in the prevention of mother-to-child transmission of HIV-1: Agence Nationale de Recherches sur le SIDA Ditrame Plus,.Abidjan, Cote d'Ivoire. J Infect Dis. 193: 482-487. 10.1086/499966.
35.
go back to reference Taylor S, Boffito M, Khoo S, Smit E, Back D: Stopping antiretroviral therapy. AIDS. 2007, 21: 1673-1682. 10.1097/QAD.0b013e3281c61394.CrossRefPubMed Taylor S, Boffito M, Khoo S, Smit E, Back D: Stopping antiretroviral therapy. AIDS. 2007, 21: 1673-1682. 10.1097/QAD.0b013e3281c61394.CrossRefPubMed
36.
go back to reference Dabis F, Bequet L, Ekouevi DK, Viho I, Rouet F, Horo A: Field efficacy of zidovudine, lamivudine and single-dose nevirapine to prevent peripartum HIV transmission. AIDS. 2005, 19: 309-318.PubMedCentralPubMed Dabis F, Bequet L, Ekouevi DK, Viho I, Rouet F, Horo A: Field efficacy of zidovudine, lamivudine and single-dose nevirapine to prevent peripartum HIV transmission. AIDS. 2005, 19: 309-318.PubMedCentralPubMed
37.
go back to reference O'Brien DP, Sauvageot D, Zachariah R, Humblet P: In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy. AIDS. 2006, 20: 1955-60. 10.1097/01.aids.0000247117.66585.ce.CrossRefPubMed O'Brien DP, Sauvageot D, Zachariah R, Humblet P: In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy. AIDS. 2006, 20: 1955-60. 10.1097/01.aids.0000247117.66585.ce.CrossRefPubMed
Metadata
Title
Provision of antiretroviral treatment in conflict settings: the experience of Médecins Sans Frontières
Authors
Daniel P O'Brien
Sarah Venis
Jane Greig
Leslie Shanks
Tom Ellman
Kalpana Sabapathy
Lisa Frigati
Clair Mills
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Conflict and Health / Issue 1/2010
Electronic ISSN: 1752-1505
DOI
https://doi.org/10.1186/1752-1505-4-12

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