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Open Access 01-12-2009 | Review

Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline

Authors: Mark Schiffman, Gary Clifford, Franco M Buonaguro

Published in: Infectious Agents and Cancer | Issue 1/2009

Abstract

Virtually all cases of cervical cancer are caused by persistent infections with a restricted set of human papillomaviruses (HPV). Some HPV types, like HPV16 and HPV18, are clear and powerful carcinogens. However, the categorization of the most weakly carcinogenic HPV types is extremely challenging. The decisions are important for screening test and vaccine development. This article describes for open discussion an approach recently taken by a World Health Organization International Agency for Research on Cancer (IARC) Monographs Working Group to re-assess the carcinogenicity of different HPV types.

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Title: Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline
Authors: Mark Schiffman
Gary Clifford
Franco M Buonaguro
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: Infectious Agents and Cancer / Issue 1/2009
Electronic ISSN: 1750-9378
DOI: https://doi.org/10.1186/1750-9378-4-8

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