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Chinese Medicine
Published in: Chinese Medicine 1/2009

Open Access 01-12-2009 | Research

Effects of Kombucha on oxidative stress induced nephrotoxicity in rats

Author: Ola Ali Gharib

Published in: Chinese Medicine | Issue 1/2009

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Abstract

Background

Trichloroethylene (TCE) may induce oxidative stress which generates free radicals and alters antioxidants or oxygen-free radical scavenging enzymes.

Methods

Twenty male albino rats were divided into four groups: (1) the control group treated with vehicle, (2) Kombucha (KT)-treated group, (3) TCE-treated group and (4) KT/TCE-treated group. Kidney lipid peroxidation, glutathione content, nitric oxide (NO) and total blood free radical concentrations were evaluated. Serum urea, creatinine level, gamma-glutamyl transferase (GGT) and lactate dehydrogenase (LDH) activities were also measured.

Results

TCE administration increased the malondiahyde (MDA) and NO contents in kidney, urea and creatinine concentrations in serum, total free radical level in blood and GGT and LDH activities in serum, whereas it decreased the glutathione (GSH) level in kidney homogenate. KT administration significantly improved lipid peroxidation and oxidative stress induced by TCE.

Conclusion

The present study indicates that Kombucha may repair damage caused by environmental pollutants such as TCE and may be beneficial to patient suffering from renal impairment.
Appendix
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Metadata
Title
Effects of Kombucha on oxidative stress induced nephrotoxicity in rats
Author
Ola Ali Gharib
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2009
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/1749-8546-4-23

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