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Chinese Medicine
Published in: Chinese Medicine 1/2009

Open Access 01-12-2009 | Review

Effect of Fuzheng Huayu formula and its actions against liver fibrosis

Authors: Chenghai Liu, Yiyang Hu, Lieming Xu, Cheng Liu, Ping Liu

Published in: Chinese Medicine | Issue 1/2009

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Abstract

Liver fibrosis is a common histological process to develop into cirrhosis in various chronic liver diseases including chronic hepatitis and fatty liver. Therefore anti-liver fibrosis is very important strategy to treat chronic liver diseases. Fuzheng Huayu (FZHY), a preparation containing herbs such as Radix Salvia Miltiorrhizae, Cordyceps, Semen Persicae, was formulated on the basis of Chinese medicine theory in treating liver fibrosis and was approved. Pharmacological studies and clinical trials demonstrate that FZHY has a significant effect against liver fibrosis and that many of the pharmacological actions are attributable to the effect. This article reviews the effects and actions of FZHY, in particular the effects observed from clinical trials in treating liver fibrosis caused by chronic hepatitis B and the actions on inhibition of hepatic stellate cell activation, protection of hepatocytes and inhibition of hepatic sinusoidal capillarization. This article also reviews the coordinated effects of the constituent herbs of FZHY and the actions of their active compounds such as salvianonic acid B (SA-B) on liver fibrosis.
Appendix
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Metadata
Title
Effect of Fuzheng Huayu formula and its actions against liver fibrosis
Authors
Chenghai Liu
Yiyang Hu
Lieming Xu
Cheng Liu
Ping Liu
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2009
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/1749-8546-4-12

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