Skip to main content
Top
Published in: Journal of Cardiothoracic Surgery 1/2011

Open Access 01-12-2011 | Research article

Risk analysis and outcome of mediastinal wound and deep mediastinal wound infections with specific emphasis to omental transposition

Authors: Haralabos Parissis, Bassel Al-Alao, Alan Soo, David Orr, Vincent Young

Published in: Journal of Cardiothoracic Surgery | Issue 1/2011

Login to get access

Abstract

Background

To report our experience, with Deep mediastinal wound infections (DMWI). Emphasis was given to the management of deep infections with omental flaps

Methods

From February 2000 to October 2007, out of 3896 cardiac surgery patients (prospective data collection) 120 pts (3.02%) developed sternal wound infections. There were 104 males & 16 females; (73.7%) CABG, (13.5%) Valves & (9.32%) CABG and Valve.

Results

Superficial sternal wound infection detected in 68 patients (1.75%) and fifty-two patients (1.34%) developed DMWI. The incremental risk factors for development of DMWI were: Diabetes (OR = 3.62, CI = 1.2-10.98), Pre Op Creatinine > 200 μmol/l (OR = 3.33, CI = 1.14-9.7) and Prolong ventilation (OR = 4.16, CI = 1.73-9.98). Overall mortality for the DMWI was 9.3% and the specific mortality of the omental flap group was 8.3%. 19% of the "DMWI group", developed complications: hematoma 6%, partial flap loss 3.0%, wound dehiscence 5.3%. Mean Hospital Stay: 59 ± 21.5 days.

Conclusion

Post cardiac surgery sternal wound complications remain challenging. The role of multidisciplinary approach is fundamental, as is the importance of an aggressive early wound exploration especially for deep sternal infections.
Appendix
Available only for authorised users
Literature
1.
go back to reference Riddlerstolpe L, Gill H, Granfeldt H, Rutberg H: Superficial and deep sternal wound complications: incidence, risk factors and mortality. Eur J Cardiothorac Surg. 2001, 20: 1168-75. 10.1016/S1010-7940(01)00991-5.CrossRef Riddlerstolpe L, Gill H, Granfeldt H, Rutberg H: Superficial and deep sternal wound complications: incidence, risk factors and mortality. Eur J Cardiothorac Surg. 2001, 20: 1168-75. 10.1016/S1010-7940(01)00991-5.CrossRef
2.
go back to reference Olsen MA, Lock-Buckley P, Hopkins D, Polish LB, Sundt TM, Fraser VJ: The risk factors for deep and superficial chest surgical-site infections after coronary artery bypass graft surgery are different. J Thorac Cardiovasc Surg. 2002, 124 (1): 136-45. 10.1067/mtc.2002.122306.CrossRefPubMed Olsen MA, Lock-Buckley P, Hopkins D, Polish LB, Sundt TM, Fraser VJ: The risk factors for deep and superficial chest surgical-site infections after coronary artery bypass graft surgery are different. J Thorac Cardiovasc Surg. 2002, 124 (1): 136-45. 10.1067/mtc.2002.122306.CrossRefPubMed
3.
go back to reference The Parisian Mediastinitis Study Group: Risk factors for deep sternal wound infection after sternotomy: a prospective, multicenter study. J Thorac Cardiovasc Surg. 1996, 111: 1200-7.CrossRef The Parisian Mediastinitis Study Group: Risk factors for deep sternal wound infection after sternotomy: a prospective, multicenter study. J Thorac Cardiovasc Surg. 1996, 111: 1200-7.CrossRef
4.
go back to reference Loop FDLytle BW, Cosgrove DM, Mahfood S, McHenry MC, Goormastic M, Stewart RW, Golding LA, Taylor PCJ: Maxwell Chamberlain memorial paper: sternal wound complications after isolated coronary artery bypass grafting: early and late mortality, morbidity and cost of care. Ann Thorac Surg. 1990, 49: 179-87. 10.1016/0003-4975(90)90136-T.CrossRef Loop FDLytle BW, Cosgrove DM, Mahfood S, McHenry MC, Goormastic M, Stewart RW, Golding LA, Taylor PCJ: Maxwell Chamberlain memorial paper: sternal wound complications after isolated coronary artery bypass grafting: early and late mortality, morbidity and cost of care. Ann Thorac Surg. 1990, 49: 179-87. 10.1016/0003-4975(90)90136-T.CrossRef
5.
go back to reference El Oakley RM, Wright JE: Postoperative mediastinitis: classification and management. Ann Thorac Surg. 1996, 61: 1030-6. 10.1016/0003-4975(95)01035-1.CrossRefPubMed El Oakley RM, Wright JE: Postoperative mediastinitis: classification and management. Ann Thorac Surg. 1996, 61: 1030-6. 10.1016/0003-4975(95)01035-1.CrossRefPubMed
6.
go back to reference Jones G, Jurkiewicz MJ, Bostwick J, Wood R, Bried JT, Culbertson J, Howell R, Eaves F, Carlson G, Nahai F: Management of the infected median sternotomy wound with muscle flaps. The Emory 20-year experience. Ann Surg. 1997, 225 (6): 766-76. 10.1097/00000658-199706000-00014. discussion 776-8CrossRefPubMedPubMedCentral Jones G, Jurkiewicz MJ, Bostwick J, Wood R, Bried JT, Culbertson J, Howell R, Eaves F, Carlson G, Nahai F: Management of the infected median sternotomy wound with muscle flaps. The Emory 20-year experience. Ann Surg. 1997, 225 (6): 766-76. 10.1097/00000658-199706000-00014. discussion 776-8CrossRefPubMedPubMedCentral
7.
go back to reference Petzina R, Hoffmann J, Navasardyan A, Malmsjö M, Stamm C, Unbehaun A, Hetzer R: Negative pressure wound therapy for post-sternotomy mediastinitis reduces mortality rate and sternal re-infection rate compared to conventional treatment. Eur J Cardiothorac Surg. 2010, 38 (1): 110-3. 10.1016/j.ejcts.2010.01.028.CrossRefPubMed Petzina R, Hoffmann J, Navasardyan A, Malmsjö M, Stamm C, Unbehaun A, Hetzer R: Negative pressure wound therapy for post-sternotomy mediastinitis reduces mortality rate and sternal re-infection rate compared to conventional treatment. Eur J Cardiothorac Surg. 2010, 38 (1): 110-3. 10.1016/j.ejcts.2010.01.028.CrossRefPubMed
8.
go back to reference Hultman CS, Carlson GW, Losken A, Jones G, Culbertson J, Mackay G, Bostwick J, Jurkiewicz MJ: Utility of the omentum in the reconstruction of complex extraperitoneal wounds and defects: donor-site complications in 135 patients from 1975 to 2000. Ann Surg. 2002, 235 (6): 782-95. 10.1097/00000658-200206000-00005.CrossRefPubMedPubMedCentral Hultman CS, Carlson GW, Losken A, Jones G, Culbertson J, Mackay G, Bostwick J, Jurkiewicz MJ: Utility of the omentum in the reconstruction of complex extraperitoneal wounds and defects: donor-site complications in 135 patients from 1975 to 2000. Ann Surg. 2002, 235 (6): 782-95. 10.1097/00000658-200206000-00005.CrossRefPubMedPubMedCentral
9.
go back to reference Reiss N, Schuett U, Kemper M, Bairaktaris A, Koerfer R: New method for sternal closure after vacuum-assisted therapy in deep sternal infections after cardiac surgery. Ann Thorac Surg. 2007, 83 (6): 2246-7. 10.1016/j.athoracsur.2006.07.077.CrossRefPubMed Reiss N, Schuett U, Kemper M, Bairaktaris A, Koerfer R: New method for sternal closure after vacuum-assisted therapy in deep sternal infections after cardiac surgery. Ann Thorac Surg. 2007, 83 (6): 2246-7. 10.1016/j.athoracsur.2006.07.077.CrossRefPubMed
10.
go back to reference Baillot R, Cloutier D, Montalin L, Côté L, Lellouche F, Houde C, Gaudreau G, Voisine P: Impact of deep sternal wound infection management with vacuum-assisted closure therapy followed by sternal osteosynthesis: a 15-year review of 23,499 sternotomies. Eur J Cardiothorac Surg. 2010, 37 (4): 880-7. 10.1016/j.ejcts.2009.09.023.CrossRefPubMed Baillot R, Cloutier D, Montalin L, Côté L, Lellouche F, Houde C, Gaudreau G, Voisine P: Impact of deep sternal wound infection management with vacuum-assisted closure therapy followed by sternal osteosynthesis: a 15-year review of 23,499 sternotomies. Eur J Cardiothorac Surg. 2010, 37 (4): 880-7. 10.1016/j.ejcts.2009.09.023.CrossRefPubMed
11.
go back to reference Immer FF, Durrer M, Mühlemann KS, Erni D, Gahl B, Carrel TP: Deep sternal wound infection after cardiac surgery: modality of treatment and outcome. Ann Thorac Surg. 2005, 80 (3): 957-61. 10.1016/j.athoracsur.2005.03.035.CrossRefPubMed Immer FF, Durrer M, Mühlemann KS, Erni D, Gahl B, Carrel TP: Deep sternal wound infection after cardiac surgery: modality of treatment and outcome. Ann Thorac Surg. 2005, 80 (3): 957-61. 10.1016/j.athoracsur.2005.03.035.CrossRefPubMed
12.
go back to reference Khanlari B, Elzi L, Estermann L, Weisser M, Brett W, Grapow M, Battegay M, Widmer AF, Flückiger U: A rifampicin-containing antibiotic treatment improves outcome of staphylococcal deep sternal wound infections. J Antimicrob Chemother. 2010, 65 (8): 1799-806. 10.1093/jac/dkq182.CrossRefPubMed Khanlari B, Elzi L, Estermann L, Weisser M, Brett W, Grapow M, Battegay M, Widmer AF, Flückiger U: A rifampicin-containing antibiotic treatment improves outcome of staphylococcal deep sternal wound infections. J Antimicrob Chemother. 2010, 65 (8): 1799-806. 10.1093/jac/dkq182.CrossRefPubMed
13.
go back to reference Netscher DT, Eladoumikdachi F, McHugh PM, Thornby J, Soltero E: Sternal wound debridement and muscle flap reconstruction: functional implications. Ann Plast Surg. 2003, 51 (2): 115-22. 10.1097/01.SAP.0000058497.92264.E2. discussion 123-5CrossRefPubMed Netscher DT, Eladoumikdachi F, McHugh PM, Thornby J, Soltero E: Sternal wound debridement and muscle flap reconstruction: functional implications. Ann Plast Surg. 2003, 51 (2): 115-22. 10.1097/01.SAP.0000058497.92264.E2. discussion 123-5CrossRefPubMed
14.
go back to reference Sachithanandan A, Nanjaiah P, Nightingale P, Wilson IC, Graham TR, Rooney SJ, Keogh BE, Pagano D: Deep sternal wound infection requiring revision surgery: impact on mid-term survival following cardiac surgery. Europ J of Cardiothorac Surgery. 2008, 673-678. 33 Sachithanandan A, Nanjaiah P, Nightingale P, Wilson IC, Graham TR, Rooney SJ, Keogh BE, Pagano D: Deep sternal wound infection requiring revision surgery: impact on mid-term survival following cardiac surgery. Europ J of Cardiothorac Surgery. 2008, 673-678. 33
15.
go back to reference Douville EC, Asaph JW, Dworkin RJ, Handy JR, Canepa CS, Grunkemeier GL, Wu Y: Sternal preservation: a better way to treat most sternal wound complications after cardiac surgery. Ann Thorac Surg. 2004, 78 (5): 1659-64. 10.1016/j.athoracsur.2004.04.082.CrossRefPubMed Douville EC, Asaph JW, Dworkin RJ, Handy JR, Canepa CS, Grunkemeier GL, Wu Y: Sternal preservation: a better way to treat most sternal wound complications after cardiac surgery. Ann Thorac Surg. 2004, 78 (5): 1659-64. 10.1016/j.athoracsur.2004.04.082.CrossRefPubMed
16.
go back to reference Hultman CS, Culbertson JH, Jones GE, Losken A, Kumar AV, Carlson GW, Bostwick J, Jurkiewicz MJ: Thoracic reconstruction with the omentum: indications, complications, and results. Ann Plast Surg. 2001, 46 (3): 242-9. 10.1097/00000637-200103000-00007.CrossRefPubMed Hultman CS, Culbertson JH, Jones GE, Losken A, Kumar AV, Carlson GW, Bostwick J, Jurkiewicz MJ: Thoracic reconstruction with the omentum: indications, complications, and results. Ann Plast Surg. 2001, 46 (3): 242-9. 10.1097/00000637-200103000-00007.CrossRefPubMed
17.
go back to reference Yasuura K, Okamoto H, Morita S, Ogawa Y, Sawazaki M, Seki A, Masumoto H, Matsuura A, Maseki T, Torii S: Results of omental flap transposition for deep sternal wound infection after cardiovascular. surgery Ann Surg. 1998, 227 (3): 455-9. 10.1097/00000658-199803000-00019.CrossRefPubMed Yasuura K, Okamoto H, Morita S, Ogawa Y, Sawazaki M, Seki A, Masumoto H, Matsuura A, Maseki T, Torii S: Results of omental flap transposition for deep sternal wound infection after cardiovascular. surgery Ann Surg. 1998, 227 (3): 455-9. 10.1097/00000658-199803000-00019.CrossRefPubMed
18.
go back to reference Ringelman PR, Vander Kolk CA, Cameron D, Baumgartner WA, Manson PN: Long-term results of flap reconstruction in median sternotomy wound infections. Plast Reconstr Surg. 1994, 93 (6): 1208-14. 10.1097/00006534-199405000-00015. discussion 1215-6CrossRefPubMed Ringelman PR, Vander Kolk CA, Cameron D, Baumgartner WA, Manson PN: Long-term results of flap reconstruction in median sternotomy wound infections. Plast Reconstr Surg. 1994, 93 (6): 1208-14. 10.1097/00006534-199405000-00015. discussion 1215-6CrossRefPubMed
19.
go back to reference Braxton JH, Marrin CA, McGrath PD, Ross CS, Morton JR, Norotsky M, Charlesworth DC, Lahey SJ, Clough RA, O'Connor GT, Northern New England Cardiovascular Disease Study Group: Mediastinitis and long-term survival after coronary artery bypass graft surgery. Ann Thorac Surg. 2000, 70 (6): 2004-7. 10.1016/S0003-4975(00)01814-2.CrossRefPubMed Braxton JH, Marrin CA, McGrath PD, Ross CS, Morton JR, Norotsky M, Charlesworth DC, Lahey SJ, Clough RA, O'Connor GT, Northern New England Cardiovascular Disease Study Group: Mediastinitis and long-term survival after coronary artery bypass graft surgery. Ann Thorac Surg. 2000, 70 (6): 2004-7. 10.1016/S0003-4975(00)01814-2.CrossRefPubMed
20.
go back to reference Brandt C, Alvarez JM: First-line treatment of deep sternal infection by a plastic surgical approach: superior results compared with conventional cardiac surgical orthodoxy. Plast Reconstr Surg. 2002, 109 (7): 2231-7. 10.1097/00006534-200206000-00009.CrossRefPubMed Brandt C, Alvarez JM: First-line treatment of deep sternal infection by a plastic surgical approach: superior results compared with conventional cardiac surgical orthodoxy. Plast Reconstr Surg. 2002, 109 (7): 2231-7. 10.1097/00006534-200206000-00009.CrossRefPubMed
21.
go back to reference Eifert S, Kronschnabl S, Kaczmarek I, Reichart B, Vicol C: Omental flap for recurrent deep sternal wound infection and mediastinitis after cardiac surgery. Thorac Cardiovasc Surg. 2007, 55 (6): 371-4. 10.1055/s-2007-965305.CrossRefPubMed Eifert S, Kronschnabl S, Kaczmarek I, Reichart B, Vicol C: Omental flap for recurrent deep sternal wound infection and mediastinitis after cardiac surgery. Thorac Cardiovasc Surg. 2007, 55 (6): 371-4. 10.1055/s-2007-965305.CrossRefPubMed
22.
go back to reference Matros E, Aranki SF, Bayer LR, McGurk S, Neuwalder J, Orgill DP: Reduction in incidence of deep sternal wound infections: random or real?. J Thorac Cardiovasc Surg. 2010, 139 (3): 680-5. 10.1016/j.jtcvs.2009.10.006.CrossRefPubMed Matros E, Aranki SF, Bayer LR, McGurk S, Neuwalder J, Orgill DP: Reduction in incidence of deep sternal wound infections: random or real?. J Thorac Cardiovasc Surg. 2010, 139 (3): 680-5. 10.1016/j.jtcvs.2009.10.006.CrossRefPubMed
23.
go back to reference Schimmer C, Reents W, Berneder S, Eigel P, Sezer O, Scheld H, Sahraoui K, Gansera B, Deppert O, Rubio A, Feyrer R, Sauer C, Elert O, Leyh R: Prevention of sternal dehiscence and infection in high-risk patients: a prospective randomized multicenter trial. Ann Thorac Surg. 2008, 86 (6): 1897-904. 10.1016/j.athoracsur.2008.08.071.CrossRefPubMed Schimmer C, Reents W, Berneder S, Eigel P, Sezer O, Scheld H, Sahraoui K, Gansera B, Deppert O, Rubio A, Feyrer R, Sauer C, Elert O, Leyh R: Prevention of sternal dehiscence and infection in high-risk patients: a prospective randomized multicenter trial. Ann Thorac Surg. 2008, 86 (6): 1897-904. 10.1016/j.athoracsur.2008.08.071.CrossRefPubMed
24.
go back to reference Graf K, Ott E, Vonberg RP, Kuehn C, Haverich A, Chaberny IF: Economic aspects of deep sternal wound infections. Eur J Cardiothorac Surg. 2010, 37 (4): 893-6. 10.1016/j.ejcts.2009.10.005.CrossRefPubMed Graf K, Ott E, Vonberg RP, Kuehn C, Haverich A, Chaberny IF: Economic aspects of deep sternal wound infections. Eur J Cardiothorac Surg. 2010, 37 (4): 893-6. 10.1016/j.ejcts.2009.10.005.CrossRefPubMed
Metadata
Title
Risk analysis and outcome of mediastinal wound and deep mediastinal wound infections with specific emphasis to omental transposition
Authors
Haralabos Parissis
Bassel Al-Alao
Alan Soo
David Orr
Vincent Young
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2011
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/1749-8090-6-111

Other articles of this Issue 1/2011

Journal of Cardiothoracic Surgery 1/2011 Go to the issue