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Open Access 01-12-2013 | Research

Intensity-modulated radiation therapy using static ports of tomotherapy (TomoDirect): comparison with the TomoHelical mode

Authors: Taro Murai, Yuta Shibamoto, Yoshihiko Manabe, Rumi Murata, Chikao Sugie, Akihiro Hayashi, Hiroya Ito, Yoshihito Miyoshi

Published in: Radiation Oncology | Issue 1/2013

Abstract

Purpose

With the new mode of Tomotherapy, irradiation can be delivered using static ports of the TomoDirect mode. The purpose of this study was to evaluate the characteristics of TomoDirect plans compared to conventional TomoHelical plans.

Methods

TomoDirect and TomoHelical plans were compared in 46 patients with a prostate, thoracic wall or lung tumor. The mean target dose was used as the prescription dose. The minimum coverage dose of 95% of the target (D95%), conformity index (CI), uniformity index (UI), dose distribution in organs at risk and treatment time were evaluated. For TomoDirect, 2 to 5 static ports were used depending on the tumor location.

Results

For the prostate target volume, TomoDirect plans could not reduce the rectal dose and required a longer treatment time than TomoHelical. For the thoracic wall target volume, the V5Gy of the lung or liver was lower in TomoDirect than in TomoHelical (p = 0.02). For the lung target volume, TomoDirect yielded higher CI (p = 0.009) but smaller V5Gy of the lung (p = 0.005) than TomoHelical. Treatment time did not differ significantly between the thoracic wall and lung plans.

Conclusion

Prostate cancers should be treated with the TomoHelical mode. Considering the risk of low-dose radiation to the lung, the TomoDirect mode could be an option for thoracic wall and lung tumors.

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Mackie TR: History of tootherapy. Phys Med Biol 2006, 51: R427-53. 10.1088/0031-9155/51/13/R24CrossRefPubMed

Mackie TR, Holmes T, Swerdloff S, Reckwerdt P, Deasy JO, Yang J: Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy. Med Phys 1993, 20: 1709-19. 10.1118/1.596958CrossRefPubMed

Franco P, Catuzzo P, Cante D, La Porta MR, Sciacero P, Girelli G: TomoDirect: an efficient means to deliver radiation at static angles with tomotherapy. Tumori 2011, 97: 498-502.PubMed

Reynders T, Tournel K, De Coninck P, Heymann S, Vinh-Hung V, Van Parijs H: Dosimetric assessment of static and helical TomoTherapy in the clinical implementation of breast cancer treatments. Radiother Oncol 2009, 93: 71-9. 10.1016/j.radonc.2009.07.005CrossRefPubMed

Bhide SA, Nutting CM: Recent advances in radiotherapy. BMC Med 2010, 8: 25. 10.1186/1741-7015-8-25CrossRefPubMedPubMedCentral

Kissick MW, Mo X, McCall KC, Schubert LK, Westerly DC, Mackie TR: A phantom model demonstration of tomotherapy dose painting delivery, including managed respiratory motion without motion management. Phys Med Biol 2010, 55: 2983-95. 10.1088/0031-9155/55/10/012CrossRefPubMedPubMedCentral

Kissick MW, Flynn RT, Westerly DC, Hoban PW, Mo X, Soisson ET: On the impact of longitudinal breathing motion randomness for tomotherapy delivery. Phys Med Biol 2008, 53: 4855-73. 10.1088/0031-9155/53/18/001CrossRefPubMedPubMedCentral

Kanagaki B, Read PW, Molloy JA, Larner JM, Sheng K: A motion phantom study on helical tomotherapy: the dosimetric impacts of delivery technique and motion. Phys Med Biol 2007, 52: 243-55. 10.1088/0031-9155/52/1/016CrossRefPubMed

Song CH, Pyo H, Moon SH, Kim TH, Kim DW, Cho KH: Treatment-related pneumonitis and acute esophagitis in non-small-cell lung cancer patients treated with chemotherapy and helical tomotherapy. Int J Radiat Oncol Biol Phys 2010, 78: 651-8. 10.1016/j.ijrobp.2009.08.068CrossRefPubMed

10.

Allen AM, Czerminska M, Janne PA, Sugarbaker DJ, Bueno R, Harris JR: Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma. Int J Radiat Oncol Biol Phys 2006, 65: 640-5. 10.1016/j.ijrobp.2006.03.012CrossRefPubMed

11.

Rice DC, Smythe WR, Liao Z, Guerrero T, Chang JY, McAleer MF: Dose-dependent pulmonary toxicity after postoperative intensity-modulated radiotherapy for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys 2007, 69: 350-7. 10.1016/j.ijrobp.2007.03.011CrossRefPubMed

12.

Kristensen CA, Nottrup TJ, Berthelsen AK, Kjaer-Kristoffersen F, Ravn J, Sorensen JB: Pulmonary toxicity following IMRT after extrapleural pneumonectomy for malignant pleural mesothelioma. Radiother Oncol 2009, 92: 96-9. 10.1016/j.radonc.2009.03.011CrossRefPubMed

13.

Baba F, Shibamoto Y, Tomita N, Ikeya-Hashizume C, Oda K, Ayakawa S: Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results. Radiat Oncol 2009, 4: 15. 10.1186/1748-717X-4-15CrossRefPubMedPubMedCentral

14.

Shibamoto Y, Naruse A, Fukuma H, Ayakawa S, Sugie C, Tomita N: Influence of contrast materials on dose calculation in radiotherapy planning using computed tomography for tumors at various anatomical regions: a prospective study. Radiother Oncol 2007, 84: 52-55. 10.1016/j.radonc.2007.05.015CrossRefPubMed

15.

Paddick I: A simple scoring ratio to index the conformity of radiosurgical treatment plans. Technical note. J Neurosurg 2000,3(93):219-222.

16.

Nakamura JL, Verhey LJ, Smith V, Petti PL, Lamborn KR, Larson DA: Dose conformity of gamma knife radiosurgery and risk factors for complications. Int J Radiat Oncol Biol Phys 2001, 51: 1313-9. 10.1016/S0360-3016(01)01757-6CrossRefPubMed

17.

Joseph KJ, Syme A, Small C, Warkentin H, Quon H, Ghosh S: A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer. Radiother Oncol 2010,94(1):60-6. 10.1016/j.radonc.2009.10.003CrossRefPubMed

18.

Edge SB, Byrd DR, Compton CC Prostate. AJCC Cancer Staging Manual. In American Joint Committee on Cancer. 7th edition. New York: Springer; 2010:457-468.

19.

Takemoto S, Shibamoto Y, Ayakawa S, Nagai A, Hayashi A, Ogino H: Treatment and prognosis of patients with late rectal bleeding after intensity-modulated radiation therapy for prostate cancer. Radiat Oncol 2012, 7: 87. 10.1186/1748-717X-7-87CrossRefPubMedPubMedCentral

20.

Davidson MT, Blake SJ, Batchelar DL, Cheung P, Mah K: Assessing the role of volumetric modulated arc therapy (VMAT) relative to IMRT and helical tomotherapy in the management of localized, locally advanced, and post-operative prostate cancer. Int J Radiat Oncol Biol Phys 2011, 80: 1550-8. 10.1016/j.ijrobp.2010.10.024CrossRefPubMed

21.

Adkison JB, Khuntia D, Bentzen SM, Cannon GM, Tome WA, Jaradat H: Dose escalated, hypofractionated radiotherapy using helical tomotherapy for inoperable non-small cell lung cancer: preliminary results of a risk-stratified phase I dose escalation study. Technol Cancer Res Treat 2008, 7: 441-7.CrossRefPubMedPubMedCentral

22.

Chen YJ, Liu A, Han C, Tsai PT, Schultheiss TE, Pezner RD: Helical tomotherapy for radiotherapy in esophageal cancer: a preferred plan with better conformal target coverage and more homogeneous dose distribution. Med Dosim 2007, 32: 166-71. 10.1016/j.meddos.2006.12.003CrossRefPubMed

23.

Bentzen SM, Trotti A: Evaluation of early and late toxicities in chemoradiation trials. J Clin Oncol 2007, 25: 4096-103. 10.1200/JCO.2007.13.3983CrossRefPubMed

24.

Shibamoto Y, Jeremic B: Biologic premises of combined radiation therapy and chemotherapy in lung cancer. Hematol Oncol Clin N Am 2004, 18: 29-40. 10.1016/S0889-8588(03)00151-5CrossRef

25.

Vogelius IS, Westerly DC, Cannon GM, Mackie TR, Mehta MP, Sugie C: Intensity-modulated radiotherapy might increase pneumonitis risk relative to three-dimensional conformal radiotherapy in patients receiving combined chemotherapy and radiotherapy: a modeling study of dose dumping. Int J Radiat Oncol Biol Phys 2011, 80: 893-9. 10.1016/j.ijrobp.2010.12.073CrossRefPubMedPubMedCentral

26.

Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS: Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys 2010,76(3 Suppl):S70-6.CrossRefPubMedPubMedCentral

Title: Intensity-modulated radiation therapy using static ports of tomotherapy (TomoDirect): comparison with the TomoHelical mode
Authors: Taro Murai
Yuta Shibamoto
Yoshihiko Manabe
Rumi Murata
Chikao Sugie
Akihiro Hayashi
Hiroya Ito
Yoshihito Miyoshi
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2013
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-8-68

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intensity-modulated radiation therapy using static ports of tomotherapy (TomoDirect): comparison with the TomoHelical mode

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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