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Open Access 01-12-2013 | Research

Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study

Authors: Shiang-Jiun Tsai, Yung-Sung Huang, Chien-Hsueh Tung, Ching-Chih Lee, Moon-Sing Lee, Wen-Yen Chiou, Hon-Yi Lin, Feng-Chun Hsu, Chih-Hsin Tsai, Yu-Chieh Su, Shih-Kai Hung

Published in: Radiation Oncology | Issue 1/2013

Abstract

Background

Increased risk of ischemic stroke has been validated for several cancers, but limited study evaluated this risk in cervical cancer patients. Our study aimed to evaluate the risk of ischemic stroke in cervical cancer patients.

Methods

The study analyzed data from the 2003 to 2008 National Health Insurance Research Database (NHIRD) provided by the National Health Research Institutes in Taiwan. Totally, 893 cervical cancer patients after radiotherapy and 1786 appendectomy patients were eligible. The Kaplan-Meier method and the Cox proportional hazards model were used to assess the risk of ischemic stroke.

Results

The 5-year cumulative risk of ischemic stroke was significantly higher for the cervical cancer group than for the control group (7.8% vs 5.1%; p <0.005). The risk of stroke was higher in younger (age <51 years) than in older (age ≥51 years) cervical cancer patients (HR = 2.73, p = 0.04; HR = 1.37, p = 0.07) and in patients with more than two comorbid risk factors (5 years cumulative stroke rate of two comorbidities: 15% compared to no comorbidities: 4%).

Conclusions

These study demonstrated cervical cancer patients had a higher risk of ischemic stroke than the general population, especially in younger patients. Strategies to reduce this risk should be assessed.

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Title: Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study
Authors: Shiang-Jiun Tsai
Yung-Sung Huang
Chien-Hsueh Tung
Ching-Chih Lee
Moon-Sing Lee
Wen-Yen Chiou
Hon-Yi Lin
Feng-Chun Hsu
Chih-Hsin Tsai
Yu-Chieh Su
Shih-Kai Hung
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2013
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-8-41

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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