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Open Access 01-12-2008 | Study protocol

Protocol for economic evaluation alongside the IMPLEMENT cluster randomised controlled trial

Authors: Duncan Mortimer, Simon D French, Joanne E McKenzie, Denise A O'Connor, Sally E Green, the IMPLEMENT study group

Published in: Implementation Science | Issue 1/2008

Abstract

Background

The recent development and publication of evidence-based clinical practice guidelines (CPGs) for acute low back pain (LBP) has resulted in evidence-based recommendations that, if implemented, have the potential to improve the quality and safety of care for acute LBP. While a strategy has been specified for dissemination of the CPG for acute LBP in Australia, there is no accompanying plan for active implementation. Evidence regarding the cost-effectiveness of active implementation of CPGs for acute LBP is sparse. The IMPLEMENT study will consider the incremental benefits and costs of progressing beyond development and dissemination to implementation.

Methods/design

Cost-effectiveness and cost-utility analyses alongside the IMPLEMENT cluster randomised controlled trial (CRCT) from a societal perspective to quantify the additional costs (savings) and health gains associated with a targeted implementation strategy as compared with access to the CPG via dissemination only.

Discussion

The protocol provided here registers our intent to conduct an economic evaluation alongside the IMPLEMENT study, facilitates peer-review of proposed methods and provides a transparent statement of planned analyses.

Trial registration

Australian New Zealand Clinical Trials Registry ACTRN012606000098538

Australian Acute Musculoskeletal Pain Guidelines Group (AAMPGG): Evidence-based management of acute musculoskeletal pain. 2003, Australian Academic Press: Brisbane, [http://nhmrc.gov.au]

McKenzie JE, French SD, O'Connor DA, Grimshaw JM, Mortimer D, Michie S, Francis J, Spike N, Schattner P, Kent PM, Buchbinder R, Green SE: IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT): cluster randomised controlled trial study protocol. Implementation Science. 2008, 3 (1): 11-Epub ahead of print.CrossRefPubMedPubMedCentral

Grimshaw JM, Shirran L, Thomas R, Mowatt G, Fraser C, Bero L, Grilli R, Harvey E, Oxman A, O'Brien MA: Changing provider behavior: an overview of systematic reviews of interventions. Med Care. 2001, 39: II2-45. 10.1097/00005650-200108002-00002.CrossRefPubMed

Vale L, Thomas R, MacLennan G, Grimshaw J: Systematic review of economic evaluations and cost analyses of guideline implementation strategies. European Journal of Health Economics. 2007, 8: 111-121. 10.1007/s10198-007-0043-8.CrossRefPubMed

Hoomans T, Evers SM, Ament AJ, Hubben MW, van der Weijden T, Grimshaw JM, Severens JL: The methodological quality of economic evaluations of guideline implementation into clinical practice: a systematic review of empiric studies. Value in Health. 2007, 10: 305-316. 10.1111/j.1524-4733.2007.00175.x.CrossRefPubMed

Dijkstra RF, Niessen LW, Braspenning JC, Adang E, Grol RT: Patient-centred and professional-directed implementation strategies for diabetes guidelines: a cluster-randomized trial-based cost-effectiveness analysis. Diabetic Medicine. 2006, 23: 164-170. 10.1111/j.1464-5491.2005.01751.x.CrossRefPubMed

Rebbeck T, Maher CG, Refshauge KM: Evaluating two implementation strategies for whiplash guidelines in physiotherapy: a cluster randomised trial. Australian Journal of Physiotherapy. 2006, 52: 165-174.CrossRefPubMed

Koskinen H, Rautakorpi UM, Sintonen H, Honkanen P, Huikko S, Huovinen P, Klaukka T, Palva E, Roine RP, Sarkkinen H, Varonen H, Makela M, Mikstra Collaborative Study Group: Cost-effectiveness of implementing national guidelines in the treatment of acute otitis media in children. International Journal of Technology Assessment in Health Care. 2006, 22: 454-459. 10.1017/S0266462306051373.CrossRefPubMed

Hoeijenbos M, Bekkering T, Lamers L, Hendriks E, van Tulder M, Koopmanschap M: Cost-effectiveness of an active implementation strategy for the Dutch physiotherapy guideline for low back pain. Health Policy. 2005, 75: 85-98. 10.1016/j.healthpol.2005.02.008.CrossRefPubMed

10.

Bekkering GE, Hendriks HJM, Koes BW, Oostendorp RAB, Ostelo RWJG, Thomassen JMC, van Tulder MW: Dutch physiotherapy guideline for low back pain. Physiotherapy. 2003, 89: 82-96. 10.1016/S0031-9406(05)60579-2.CrossRef

11.

Mason J, Wood J, Freemantle J: Designing evaluations of interventions to change clinical practice. Journal of Health Services Research & Policy. 1999, 4: 106-111.

12.

Sculpher M: Evaluating the cost effectiveness of interventions designed to increase utilisation of evidence-based guidelines. Family Practice. 2000, 17: S26-S31. 10.1093/fampra/17.suppl_1.S26.CrossRefPubMed

13.

Drummond M, O'Brien B, Stoddart G, Torrance G: Methods for the economic evaluation of health programmes. 1997, New York Oxford University Press, 2

14.

Bell CM, Urbacj DR, Ray JG, Rosen AB, Greenberg D, Neumann PJ: Bias in published cost effectiveness studies: systematic review. BMJ. 2006, 332: 699-703. 10.1136/bmj.38737.607558.80.CrossRefPubMedPubMedCentral

15.

Mortimer D, Dalziel K, Segal L: Bias in published cost-effectiveness studies? Further evidence from Australia. Cost Effectiveness & Resource Allocation.

16.

Grimshaw JM, Thomas RE, MacLennan G, Fraser C, Ramsay CR, Vale L, Whitty P, Eccles MP, Matowe L, Shirran L, Wensing M, Dijkstra R, Donaldson C: Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technology Assessment. 2004, 8 (6): iii-72.CrossRefPubMed

17.

Bombardier C: Outcome assessments in the evaluation of treatment of spinal disorders: summary and general recommendations. Spine. 2000, 25: 3100-3103. 10.1097/00007632-200012150-00003.CrossRefPubMed

18.

Bellamy N: Musculoskeletal clinical metrology. 1993, Dordrecht; Boston: Kluwer Academic PublishersCrossRef

19.

Hawthorne G, Richardson J, Day N: Technical Report 12: Using the Assessment of Quality of Life (AQoL) Version 1. 2000, Melbourne: Centre for Health Program Evaluation, Monash University

20.

Hawthorne G, Richardson J, Day NA: A comparison of the Assessment of Quality of Life (AQoL) with four other generic utility instruments. Annals of Medicine. 2001, 33: 358-370.CrossRefPubMed

21.

Glick H, Polsky D, Schulman K: Trial-based economic evaluations: an overview of design and analysis. Economic evaluation in health care: merging theory with practice. Edited by: Drummond MF, McGuire A. 2001, New York: Oxford University Press

22.

Commonwealth Department of Health & Ageing: Manual of resource items and their associated costs for use in major submissions to the Pharmaceutical Benefits Advisory Committee involving economic analyses. 2002, Canberra: Commonwealth of Australia, 2

23.

Bureau of Transport Economics: Road crash costs in Australia, BTE Report 102. 2000, Canberra: AGPS

24.

Australian Bureau of Statistics: How Australians use their time, ABS Catalogue No. 4153.0. 1997, Canberra: Commonwealth of Australia

25.

Australian Bureau of Statistics: Labour Price Index, Australia. ABS Catalogue No. 6345.0, Canberra: Commonwealth of Australia.

26.

Godlee F: Publishing study protocols: making them visible will improve registration, reporting and recruitment. BMC News and Views. 2001, 2: 4.

Title: Protocol for economic evaluation alongside the IMPLEMENT cluster randomised controlled trial
Authors: Duncan Mortimer
Simon D French
Joanne E McKenzie
Denise A O'Connor
Sally E Green
the IMPLEMENT study group
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: Implementation Science / Issue 1/2008
Electronic ISSN: 1748-5908
DOI: https://doi.org/10.1186/1748-5908-3-12

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Protocol for economic evaluation alongside the IMPLEMENT cluster randomised controlled trial

Abstract

Background

Methods/design

Discussion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods/design

Discussion

Trial registration

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